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Vol 20, No 2 (2023)

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Authors in this issue:

Abdelfattah Waleed, Adis Šišić, Adisa Šabanović Adilović, Admir Mehičević, Adnan Fojnica, Adnan Papović, Adriana Levaković, Agung Putra, Alan Jahić, Aldin Jusić, Alen Džubur, Alma Efendić, Alma Jahić, Alma Mujić-Ibralić, Almir Fajkić, Almira Lujinović, Amalina Nur Dina, Amela Pasić, Amela Selimović, Amila Jašarević, Amila Zukanović, Amina Džidić-Krivić, Andreas Antzoulas, Anes Mašović, Angelos Samaras, Ariyati Yosi, Armin Šljivo, Asja Hotić-Hadžiefendić, Asmir Jonuzi, Asmir Konjić, Asmira Ljuca, Ayu Renda Sari, Ayuningtyas Utami, Azra Durak-Nalbantić, Azra Metović, Bahnasi Abdullah Abdulaziz, Bekir Rovčanin, Belma Jaganjac, Charalampos Kaplanis, Christos Tsilivigkos, Damir Marjanović, Damir Rebić, Damir Šečić, Daniela Lončar, Dejan Bokonjić, Delfitri Munir, Dimitrios Filis, Dimitrios Kehagias, Dina Kapić, Dr Mousa, Dragana Bojinović-Rodić, Dubravka Mihaljević, Dušan Mihajlović, Ðemil Omerović, Edin Begić, Edin Kabil, Edin Selimović, Elbasyouni Hany Abdelbary Abdelaziz, Elias Liolis, Elmedin Bajrić, Elsayaad Mohammed Shafiek Mohammed, Emir Begagić, Enra Mehmedika-Suljić, Ermina Mujičić, Ervin Alibegović, Esad Ćosović, Esad Pepić, Faruk Husremović, Faruk Lazović, Fatima Hukić, Fotios Iliopoulos, Francesk Mulita, Gadallah Abdel Naser Abdel Atty, Ganimeta Bakalović, George Theofanis, Georgios-Ioannis Verras, Gina Fatahi, Hajar Haryuna Tengku Siti, Hakija Bečulić, Herry Herman, Humera Porobić-Jahić, Ibrahim Omerhodžić, Iffan Alif, Igor Hudić, Ines Musa Trolić, Ioannis Maroulis, Ioannis Panagiotopoulos, Iqbal Pahlevi Nasution, Ira Armayanti, Ismar Hasukić, Ivan Lekić, Jasmin Mušanović, Jasmin Šutković, Jelena Kovačević-Prstojević, Joko Wahyu Wibowo, Khairina Nasution, Khalisanni Khalid, Konstantinos Bouchagier, Konstantinos Tasios, Larisa Gavran, Lejla Bečulić, Lejla Dervišević, Levan Tchabashvili, Lia Restimulia, Maida Šahinović, Maja Račić, Marina Michalaki, Meidina K. Wardani, Meiky Fredianto, Mirela Begić, Mirela Lisičić-Konaković, Mirza Atić, Mirza Kovačević, Mirza Sivro, Mladen Ćubela, Muhammad Ariq Nazar, Nafija Serdarević, Nedim Begić, Nedim Jahić, Nedima Kapidžić-Bašić, Nehra Mosorović, Nelfi Disya Amalia Lubis, Nermin Salkić, Nermina Rizvanović, Nermir Granov, Nevena Mahmutbegović, Nijaz Tihić, Nikolas Drakos, Nur Dina Amalina, Nurka Pranjić, Olena Shevchuk, Orhan Lepara, Putri Astrid Novianti Nazli, Rahadian Zainul, Rasim Skomorac, Redžib Direković, Risky Chandra Satria Irawan, Romana Marušić, Sabina Bećirović, Sanja Jurišić, Sebija Izetbegović, Šefik Hasukić, Sehveta Mustafić, Selvedina Sarajlić- Spahić, Senad Hasanspahić, Senad Ljuca, Senada Čaušević, Senka Mesihović-Dinarević, Slavenka Štraus, Sri Priyantini, Tarik Jarkoč, Tarik Selimović, Tatjana Bačun, Vasileios Leivaditis, Vasileios Papanikos, Viktor Shevchuk, Yankai Jiang, Yoyos Dias Ismiarto, Yurii Bezsmertnyi, Zdenka Krivokuća, Zdenko Šarac, Željka Dragila, Željko Debeljak, Zlatan Zvizdić, Zurifa Ajanović,

Published: 01.12.2023.

Contents

01.12.2022. Review paper Biochemistry
Lung cancer screening in the healthcare system of Bosnia and Herzegovina

Lung cancer incidence in Bosnia and Hercegovina is high. The implementation of evidence-based lung cancer screening based on low-dose computed tomography (LDCT) may detect lung cancer early and decrease mortality specific to lung cancer. However, LDCT receipt may be unsatisfactory in Europe due to a low distribution of scanners and radiologists or ...

By LARISA GAVRAN, GINA FATAHI, MAJA RAČIĆ

01.12.2022. Review paper Biochemistry
Morphometric analysis of clinically significant parameters of the main trunk of the left coronary artery

Aim To determine the value of angles between the left coronary artery main trunk (LMT) and its branches, the anterior interventricular branch (LAD) and the circumflex branch (CX), and their possible relationship with the LMT length. Methods A total of 29 cadaveric hearts were used. The left coronary artery and its branches were dissected. The heart...

By ALMIRA LUJINOVIĆ, LEJLA DERVIŠEVIĆ, ZURIFA AJANOVIĆ, DINA KAPIĆ, AZRA METOVIĆ, ESAD ĆOSOVIĆ, MAIDA ŠAHINOVIĆ, JASMIN MUŠANOVIĆ, JELENA KOVAČEVIĆ-PRSTOJEVIĆ, ESAD PEPIĆ

01.12.2022. Review paper Biochemistry
Risk factors associated with the development of secondary hyperparathyroidism in dialysis patients

Aim To determine risk factors associated with the development and severity of secondary hyperparathyroidism in dialysis patients.Methods A cross-sectional study at the Clinical Centre of the University of Tuzla (March 2022) included 104 adult patients (males 51.9%, females 48.1%) with chronic kidney diseases under dialysis treatment. Based on parat...

By SEHVETA MUSTAFIĆ, ALMA MUJIĆ-IBRALIĆ, FATIMA HUKIĆ, MIRZA ATIĆ, AMILA JAŠAREVIĆ, DANIELA LONČAR, HUMERA POROBIĆ-JAHIĆ, AMELA SELIMOVIĆ, NEDIM JAHIĆ

01.12.2022. Review paper Biochemistry
The most common indications for measuring metanephrine and normetanephrine in plasma – a rational approach

Aim To determine the most common indications for measuring metanephrine and normetanephrine in plasma by gender and age and to compare the concentrations of metanephrine and normetanephrine by indication, gender and age.Methods The study was conducted on 224 patients whose plasma metanephrine and normetanephrine concentrations were measured at the ...

By ROMANA MARUŠIĆ, ŽELJKA DRAGILA, ADRIANA LEVAKOVIĆ, IVAN LEKIĆ, DUBRAVKA MIHALJEVIĆ, ŽELJKO DEBELJAK, TATJANA BAČUN

01.12.2022. Review paper Biochemistry
Correlation of the inclination of the tentorium cerebellum and the volume of the posterior cranial fossa

Aim To investigate the influence of the inclination and insertion of the cerebellar tentorium on the posterior cranial fossa (PCF)volume.Methods A retrospective, non-randomized study including 174 patients (117 females and 57 males) who underwent magnetic resonance imaging in the period from 31 December 2020 to 1 June 2021 under the indication (mos...

By REDŽIB DIREKOVIĆ, HAKIJA BEČULIĆ, ZDENKA KRIVOKUĆA

01.12.2022. Review paper Biochemistry
Minimally invasive coronary artery bypass (MICS CABG) in Bosnia and Herzegovina: a single centre, single surgeon cohort experience

Aim This is the first research in Bosnia and Herzegovina presenting minimally invasive coronary artery bypass grafting surgery(MICS CABG) experience, advantages, and outcomes as compared to conventional surgery (OPEN CABG).Methods This retrospective cross-sectional study was conducted between January 2019 and November 2022 and included patientswith...

By NERMIR GRANOV, ARMIN ŠLJIVO, ERMINA MUJIČIĆ, DAMIR REBIĆ, ALEN DŽUBUR, EDIN BEGIĆ, TARIK SELIMOVIĆ, ZLATAN ZVIZDIĆ, ALMIR FAJKIĆ, ASMIR JONUZI, EDIN KABIL, SLAVENKA ŠTRAUS

01.12.2022. Review paper Biochemistry
Red blood cell distribution width as a predictor of outcome in Intensive Care Unit: a retrospective cohort study

Aim To evaluate the predictive significance of the red blood cell distribution width (RDW) >14.5 at admission to the IntensiveCare Unit (ICU) on outcome parameters: length of hospital stay (LOHS), incidence of hospital mortality, 30-day mortality and 30-day survival after hospital discharge in unselected (surgical and non-surgical) critically il...

By ASMIRA LJUCA, NERMINA RIZVANOVIĆ, SENAD LJUCA, ALMA JAHIĆ

01.12.2022. Review paper Biochemistry
COVID-19 associated coagulopathy in septic critically ill patients - a retrospective cohort study

Aim To determine the relationship between coagulation disorders and septic condition in COVID-19 critically ill patients.Methods Data from 99 patients who presented with COVID-19 acute hypoxemic respiratory failure (CAHRF) were divided intotwo groups: Group 1- patients who developed sepsis, and Group 2 - patients who developed septic shock. Age, se...

By MIRZA KOVAČEVIĆ, NERMINA RIZVANOVIĆ, ADISA ŠABANOVIĆ ADILOVIĆ, SENADA ČAUŠEVIĆ

01.12.2022. Review paper Biochemistry
Hypoxic secretome mesenchymal stem cells inhibiting interleukin-6 expression prevent oxidative stress in type 1 diabetes mellitus

Aim Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the chronic inflammation of the pancreatic islets of Langerhans. Hyperglycaemia leads to suppressed antioxidant enzyme and increased inflammation in the pancreatic cell, resulting in pancreatic cell death. Hypoxic secretome mesenchymal stem cells (HS-MSCs) are soluble mol...

By AYUNINGTYAS UTAMI, AGUNG PUTRA, JOKO WAHYU WIBOWO, AMALINA NUR DINA, RISKY CHANDRA SATRIA IRAWAN

01.12.2022. Review paper Biochemistry
Lipid status and carotid intima-media thickness in patients with end-stage renal disease

Aim To assess morphological characteristics of carotid blood vessels in uremic patients before to the initiation of the dialysis treatment, and corelate data with various dialysis therapy modules.Methods The study included 30 patients with end-stage renal disease (ERDS) prior to commencing dialysis, 30 patients treated withhaemodialysis and 30 pati...

By DAMIR REBIĆ, EDIN BEGIĆ, ARMIN ŠLJIVO, NERMIR GRANOV, SENAD HASANSPAHIĆ, ALEN DŽUBUR, AZRA DURAK-NALBANTIĆ

01.12.2022. Review paper Biochemistry
Helicobacter pylori resistance to clarithromycin and quinolones in patients with dyspepsia in Tuzla Canton, Bosnia and Herzegovina

Aim To evaluate Helicobacter pylori (H. pylori) resistance to clarithromycin and quinolones in patients with dyspepsia in TuzlaCanton, Bosnia and Herzegovina, a region with no data on clarithromycin or quinolones resistance.Methods A prospective cross-sectional study was conducted at the Department of Gastroenterology and Hepatology at UniversityCl...

By ISMAR HASUKIĆ, NERMIN SALKIĆ, NIJAZ TIHIĆ, ERVIN ALIBEGOVIĆ, ŠEFIK HASUKIĆ, ALAN JAHIĆ

01.12.2022. Review paper Biochemistry
Efficacy of nebulized hypertonic saline versus normal saline in the treatment of acute bronchiolitis in inpatient infants

Aim Compare the efficacy of nebulized hypertonic saline and normal saline in the treatment of infants hospitalized for bronchiolitis.Methods This retrospective study was conducted at the Department of Pulmonology, Paediatric Clinic, Clinical Centre University of Sarajevo, covering the period from January 2015 to December 2019 and comprising 380 chi...

By GANIMETA BAKALOVIĆ, TARIK JARKOČ, NEDIM BEGIĆ, ORHAN LEPARA, DEJAN BOKONJIĆ, DUŠAN MIHAJLOVIĆ, AMELA PASIĆ, ALMIR FAJKIĆ

01.12.2022. Review paper Biochemistry
The role of mesenchymal stem cells in allergic rhinitis and its relationship with IL-10, plasma cells and regulatory T cells

Aim Allergic rhinitis (AR) is an IgE-mediated inflammation of the nose. Regulatory T cells (Tregs), plasma cells and inflammatory cytokines have shown to play a critical role in allergic airway inflammation. The aim of the study was to investigate the role of mesenchymal stem cells (MSCs) in generating Treg cells and plasma cells associated with re...

By DELFITRI MUNIR, IQBAL PAHLEVI NASUTION, LIA RESTIMULIA, AGUNG PUTRA, NUR DINA AMALINA

01.12.2022. Review paper Biochemistry
Correlation between signal transducer and activator of transcription 1 (STAT 1), vascular endothelial growth factor (VEGF), and signal to noise ratio (SNR) value in otoacoustic emission (OAE) examination on organ of Corti cochlea due to cisplatin

Aim To assess the cochlear damage caused by cisplatin in the rat cochlea based on decreased signal to noise ratio (SNR) values on otoacoustic emission (OAE) examination and increased expression of signal transducer and activator of transcription 1 (STAT 1) and vascular endothelial growth factor (VEGF) on immunohistochemical examination.Methods Twen...

By NELFI DISYA AMALIA LUBIS, HAJAR HARYUNA TENGKU SITI, KHALISANNI KHALID, RAHADIAN ZAINUL

01.12.2022. Review paper Biochemistry
Effects of direct acting antiviral therapy on liver stiffness measured by using fibro scan in Egyptian patients with chronic hepatitis C

Aim Egypt has the highest incidence of hepatitis C virus (HCV) infection in the world. Fibrosis development is common in HCVcases, and it is important in disease prediction. The aim of this study was to demonstrate the role of fibro scan in assessment of changes in hepatic stiffness in patients with chronic HCV infection following direct acting ant...

By GADALLAH ABDEL NASER ABDEL ATTY, BAHNASI ABDULLAH ABDULAZIZ, ABDELFATTAH WALEED, DR MOUSA, ELSAYAAD MOHAMMED SHAFIEK MOHAMMED, ELBASYOUNI HANY ABDELBARY ABDELAZIZ

01.12.2022. Review paper Biochemistry
In vitro effectiveness of the avocado peel extract (Persea americana Mill) as an antifungal against Trichophyton rubrum, the cause of dermatophytosis

Aim To determine the effectiveness of avocado peel extract (Persea americana Mill) as an antifungal against T. rubrum, whichcauses dermatophytosis.Methods In vitro laboratory experimental study using a post-testonly control group design analysed active compounds of avocadopeel and continued with the antifungal activity test. In each group divided a...

By IRA ARMAYANTI, MEIDINA K. WARDANI, ARIYATI YOSI

01.12.2022. Review paper Biochemistry
Relationship between brain-derived neurotrophic factor serum levels with the severity of melasma

Aim To determine the relationship between brain-derived neurotrophic factor (BDNF) levels and the severity of melasma.Methods This cross-sectional analytic study included consecutive patients from the Dermatology and Venereology Polyclinicat Prof. dr. Chairuddin Panusunan Lubis Universitas Sumatera Utara (Prof. dr. CPL USU) Hospital Medan from May ...

By PUTRI ASTRID NOVIANTI NAZLI, ARIYATI YOSI, KHAIRINA NASUTION

01.12.2022. Review paper Biochemistry
Red algae extract suppresses caspase-3 gene expression and induces catalase antioxidant enzyme in testicles of rats induced by boric acid

Aim To determine the effect of red algae extract on the gene expression of catalase and caspase-3 in testicules of rats induced by boric acid (BA).Methods This is experimental research with post-test control group design. Twenty four healthy male Wistar rats were divided intofour treatment groups: a healthy group, negative control group, two treatm...

By AYU RENDA SARI, JOKO WAHYU WIBOWO, SRI PRIYANTINI, AGUNG PUTRA, NUR DINA AMALINA

01.12.2022. Review paper Biochemistry
Comparison of postoperative bleeding using harmonic scalpel and LigaSure in thyroid surgery: a 15-year single-centre retrospective study

Aim Thyroidectomy is the most common operation in the field of endocrine surgery. The aim of this study was to compare the use of LigaSure vessel (LS) and harmonic scalpel (HS) in 1653 total thyroidectomies between January 2008 and March of 2023, with regards to analysis of surgical bleeding complications duration the hospital stay and operative su...

By CHARALAMPOS KAPLANIS, MARINA MICHALAKI, KONSTANTINOS BOUCHAGIER, IOANNIS MAROULIS, DIMITRIOS FILIS, VASILEIOS LEIVADITIS, IOANNIS PANAGIOTOPOULOS, NIKOLAS DRAKOS, ANGELOS SAMARAS, ANDREAS ANTZOULAS, FRANCESK MULITA, DIMITRIOS KEHAGIAS, CHRISTOS TSILIVIGKOS, FOTIOS ILIOPOULOS, KONSTANTINOS TASIOS, LEVAN TCHABASHVILI, VASILEIOS PAPANIKOS, ELIAS LIOLIS, GEORGIOS-IOANNIS VERRAS, GEORGE THEOFANIS

01.12.2023. Review paper Biochemistry
Serum biomarkers in normal pressure hydrocephalus

Aim To investigate the serum value of brain derived neurotrophic factor (BDNF), proteins S-100, NSE, IL-6 in normal pressure patients (NPH) compared to control (healthy) group and also a possible correlation with radiological findings in NPH patients.Methods Study patients were included during the period of 2020-2022. All NPH patients met the diagn...

By ENRA MEHMEDIKA-SULJIĆ, SEBIJA IZETBEGOVIĆ, NAFIJA SERDAREVIĆ, BEKIR ROVČANIN, NEVENA MAHMUTBEGOVIĆ, ADMIR MEHIČEVIĆ, IBRAHIM OMERHODŽIĆ

01.12.2022. Review paper Biochemistry
Secretome of hypoxia-preconditioned mesenchymal stem cells enhance the expression of HIF-1a and bFGF in a rotator cuff tear model

Aim To determine the effect of secretome hypoxia mesenchymal stem cells (SH-MSCs) on the relative gene expression of hypoxia inducible factor-1a (HIF-1a) and basic fibroblast growth factor (bFGF) in accelerating histomorphometric repair of tendon to bone interface healing in rats acute rotator cuff tear (RCT) model.Methods This is experimental rese...

By MEIKY FREDIANTO, HERRY HERMAN, YOYOS DIAS ISMIARTO, AGUNG PUTRA, IFFAN ALIF, NUR DINA AMALINA, MUHAMMAD ARIQ NAZAR

01.12.2022. Review paper Biochemistry
The effects of two fixation methods on blood loss in patients with trochanteric fracture: dynamic hip screw vs. proximal femoral nail anti-rotation

Aim The two most commonly used implants for treatment of trochanteric fractures are the dynamic hip screw (DHS) and proximal femoral nail antirotation (PFNA). The aim of this study was to evaluate blood loss in patients with trochanteric fracture treated with DHS or PFNA.Methods This retrospective comparative study included 61 patients with trochan...

By MIRZA SIVRO, FARUK LAZOVIĆ, ÐEMIL OMEROVIĆ, ADNAN PAPOVIĆ

01.12.2022. Review paper Biochemistry
Bone healing during electrostimulation

Aim To investigate the effect of direct epineural electrical stimulation of the nerve on the nature of reparative processes in the bone stump.Methods Three series of experiments were carried out with amputation of the thigh in the middle third and muscle plasty. In the 1stand 2nd experimental series a perineural catheter was brought to the stump of...

By YURII BEZSMERTNYI, VIKTOR SHEVCHUK, YANKAI JIANG, OLENA SHEVCHUK

01.12.2022. Review paper Biochemistry
Magnetic resonance morphometry of the lumbar spinal canal in Zenica - Doboj Canton in Bosnia and Herzegovina

Aim To investigate morphometric determinants of lumbar canal in patients treated in Cantonal Hospital Zenica, and their variationaccording to gender.Methods Morphometry of lumbar spinal canal was assessed in 52 patients treated at the Department of Neurosurgery of CantonalHospital Zenica in the period between September 2022 and November 2022. Data ...

By BELMA JAGANJAC, AMINA DŽIDIĆ-KRIVIĆ, HAKIJA BEČULIĆ, ARMIN ŠLJIVO, EMIR BEGAGIĆ, ADIS ŠIŠIĆ

01.12.2022. Review paper Biochemistry
A correlation of demographic characteristics, preoperative conservative therapy and timing with postoperative outcome in herniated disc-associated cauda equina syndrome: Do they really matter?

Aim To examine a correlation of demographic characteristics of patients, preoperative modality of conservative therapy and timing on the postoperative outcome of patients six months after the operation.Methods A retrospective, non-randomized, clinical study involved 48 patients of different age and gender with a verified diagnosis ofcauda equina sy...

By HAKIJA BEČULIĆ, EMIR BEGAGIĆ, RASIM SKOMORAC, ALDIN JUSIĆ, ALMA EFENDIĆ, EDIN SELIMOVIĆ, ANES MAŠOVIĆ, LEJLA BEČULIĆ

01.12.2022. Review paper Biochemistry
Comparison of Kegel exercises and a combination of Kegel exercises with the use of the KegelSmart biofeedback device in the treatment of static urinary incontinence

Aim To determine which of the two methods, Kegel exercises or combination of Kegel exercises with the use of the KegelSmartbiofeedback device, has better therapeutic effects on the symptoms of SUI in females.Methods Fifty female patients with SUI were randomly divided into two groups: 25 treated with Kegel exercises, and 25 with thecombination of K...

By MIRELA BEGIĆ, NEDIMA KAPIDŽIĆ-BAŠIĆ, ASJA HOTIĆ-HADŽIEFENDIĆ, ASMIR KONJIĆ, DRAGANA BOJINOVIĆ-RODIĆ, IGOR HUDIĆ

01.12.2022. Review paper Biochemistry
Frequency of sweet and salty snack consumption among children in relation to their mothers' education level

Aim To investigate the frequency of consumption of sweet and salty snacks among children aged 2-18 years in relation to theirmothers’ education level.Methods A descriptive epidemiological study was conducted in five dental practices at the School of Medicine of the University ofMostar from May to October 2022. The data were collected from med...

By MIRELA LISIČIĆ-KONAKOVIĆ, SENKA MESIHOVIĆ-DINAREVIĆ, ELMEDIN BAJRIĆ, SANJA JURIŠIĆ, INES MUSA TROLIĆ, MLADEN ĆUBELA, ZDENKO ŠARAC, AMILA ZUKANOVIĆ

01.12.2022. Review paper Biochemistry
Molecular-genetics analysis of 15 STR loci in sibship testing in isolated rural Bosnian population – the use of the grey zone

Aim Examination of the effectiveness of STR loci in proving sibship of the Bosnian-Herzegovinian village of Orahovica andthe formation of a “grey zone“.Methods The probability of sibship was determined by calculating the likelihood ratio (LR) parameter for each of the 15 observedSTR loci and for each of the pairs of relatives and non-re...

By JASMIN MUŠANOVIĆ, AZRA METOVIĆ, ESAD PEPIĆ, ALMIRA LUJINOVIĆ, ADNAN FOJNICA, FARUK HUSREMOVIĆ, DAMIR ŠEČIĆ, DAMIR MARJANOVIĆ, JASMIN ŠUTKOVIĆ

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