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Review paper
Published: 01.12.2022. Biochemistry
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https://doi.org/10.17392/1560-23

Efficacy of nebulized hypertonic saline versus normal saline in the treatment of acute bronchiolitis in inpatient infants

By
Ganimeta Bakalović Orcid logo ,
Ganimeta Bakalović

Department of Pulmonology, Paediatric Clinic, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Tarik Jarkoč ,
Tarik Jarkoč

Department of Pulmonology, Paediatric Clinic, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Nedim Begić ,
Nedim Begić
Contact Nedim Begić

Department of Pulmonology, Paediatric Clinic, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Orhan Lepara ,
Orhan Lepara

School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Dejan Bokonjić ,
Dejan Bokonjić

School of Medicine Foča, University of East Sarajevo, Foča, Bosnia and Herzegovina

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Dušan Mihajlović ,
Dušan Mihajlović

School of Medicine Foča, University of East Sarajevo, Foča, Bosnia and Herzegovina

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Amela Pasić ,
Amela Pasić

Department of Pulmonology and Cardiology, Clinic for Children Disease, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina

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Almir Fajkić
Almir Fajkić

School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Abstract

Aim
Compare the efficacy of nebulized hypertonic saline and normal saline in the treatment of infants hospitalized for bronchiolitis.
Methods
This retrospective study was conducted at the Department of Pulmonology, Paediatric Clinic, Clinical Centre University of Sarajevo, covering the period from January 2015 to December 2019 and comprising 380 children aged between 1 and
12 months having bronchiolitis. One group received nebulized hypertonic saline (NHS, 3% NaCl)), and another group received nebulized normal saline (NNS, 0.9% NaCl). The control group did not receive any of these treatment options.
Results
There was no statistically significant difference between the treatment groups regarding length of hospital stay (LOS) and
Clinical Severity Score (CSS) at admission and discharge as well as in oxygen therapy duration and antibiotic use, the duration of symptoms before hospital admission, frequency of nasal discharge, elevated temperature, dyspnoea, cough and dehydration.
Conclusion
The results of this study are consistent with several recent studies or meta-analyses and support the evidence against the
use of NHS in hospitalized infants with mild or moderate bronchiolitis.

Keywords:

bronchioles,
infection,
therapy,
NaCl

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