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Review paper

In vitro effectiveness of the avocado peel extract (Persea americana Mill) as an antifungal against Trichophyton rubrum, the cause of dermatophytosis

By
Ira Armayanti Orcid logo ,
Ira Armayanti
Contact Ira Armayanti

Department of Dermatology and Venereology, Faculty of Medicine Universitas Sumatera Utara, Universitas Sumatera Utara, Medan, Indonesia

Meidina K. Wardani ,
Meidina K. Wardani

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Ariyati Yosi
Ariyati Yosi

Department of Dermatology and Venereology, Faculty of Medicine , Universitas Sumatera Utara, Medan, Indonesia

Abstract

Aim
To determine the effectiveness of avocado peel extract (Persea americana Mill) as an antifungal against T. rubrum, which
causes dermatophytosis.
Methods
In vitro laboratory experimental study using a post-testonly control group design analysed active compounds of avocado
peel and continued with the antifungal activity test. In each group divided according to the concentration of 0% (negative control), 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, and positive control (2% ketoconazole) antifungal activity test was carried out using the fungus T. rubrum ATCC 28188 for five repetitions.
Results
The avocado peel extract contained phenolic compounds, flavonoids, tannins, saponins, alkaloids, terpenoids, and glycosides. Antifungal activity test showed a significant difference with the highest mean inhibition zone diameter of T. rubrum, which was demonstrated at a concentration of 75%.
Conclusion
Avocado peel extract is useful to inhibit growth of Trichophyton rubrum in dose dependent.

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