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Edited by:

Selma Uzunović

Vol 21, No 2 (2024):

Medicinski Glasnik

Published: 01.09.2024.

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05.02.2025. Original article In the next Issue
Hypoxia-conditioned mesenchymal stem cells (MSC) exosomes attenuate ultraviolet-B (UVB)-mediated malondialdehyde (MDA) and matrix metalloproteinase-1 (MMP)-1 upregulation in collagen loss models

By Jessica Angelina, Agung Putra, Setyo Trisnadi, Dedy Hermansyah, Eko Setiawan, Titiek Sumarawati, Nur Dina Amalina

Aim To investigate the effects of exosome-derived human mesenchymal stem cells (EH-MSCs) on matrix metalloproteinase-1 (MMP)-1 and malondialdehyde (MDA) levels in ultraviolet-B (UVB)-irradiated Wistar rats.
Methods The study used a post-test-only control group design with randomized allocation. Thirty rats were exposed to UVB radiation (302 nm, 150 mJ/cm²) for 8 minutes, five times a week over two weeks. Five groups were established: a healthy control (G1), a negative control (G2), a positive control that received a 200 μL subcutaneous injection of hyaluronic acid (HA) (G3), a treatment group 1 that received a 200 μL subcutaneous injection of exosome-derived EH-MSCs (G4), and a treatment group 2 that received a 300 μL subcutaneous injection of EH-MSCs (G5). An ELISA was used to quantify the levels of MDA and MMP-1.
Results A significant reduction in the mean level of MDA in groups G4 (368.33 ± 59.67) and G5 (329.33 ± 82.06) was noted when compared to the negative control group G2 (686.58 ± 119.01) (p<0.05). Similarly, MMP-1 showed a significant decrease in mean levels for G4 (0.08 ± 0.04) and G5 (0.07 ± 0.04) compared to G2 (0.33 ± 0.06) (p<0.05).
Conclusion These findings suggest that EH-MSCs have potent antioxidant and anti-inflammatory properties, mitigating UVB-induced skin damage by reducing oxidative stress markers.

05.02.2025. Case report with a literature review In the next Issue
Type A acute aortic dissection mimicking pulmonary embolism: intramural hematoma of the pulmonary arteries causing right heart pressure overload and hemoptysis

By Emina Rovčanin Delić, Lukas Lehmkuhl, Denisa Ciubotaru, Sebastian Barth

Aim To report on an atypical complication of type A acute aortic dissection (TAAAD) mimicking pulmonary embolism with right heart pressure overload and hemoptysis due to intramural hematoma of the pulmonary arteries extending into the pulmonary interstitium.
Methods A 66-years old male presented with sudden chest pain, dyspnoea and nausea. Electrocardiogram (ECG), point of care ultrasound (POCUS) of the heart and tripple rule out computed tomography (CT) were performed to differentiate the cause of acute chest pain.
Results ECG showed no ischemia. POCUS of the heart showed aneurysmal ascending aorta (4,5 cm), suspected intimal flap, mild aortic regurgitation, minimal pericardial effusion, right heart dilatation with impaired function. CT confirmed TAAAD with extensive intramural hematoma around the central pulmonary arteries propagating to intrapulmonary branches. Additionally, there was dilatation of the right ventricle and right atrium indicative of right heart pressure overload along mild haemorrhagic pericardial effusion anterior to the right ventricle. No evidence of pulmonary embolism was found. Emergency surgery included the replacement of the supracoronary ascending aorta and aortic hemiarch. 
Conclusion TAAAD is a rare but life-threatening cause of chest pain often mimicking other conditions such as pulmonary embolism. Pulmonary complications including intramural hematoma of the pulmonic trunk due to its shared adventitia with ascending aorta are rare but clinically significant, causing lumen reduction or occlusion of pulmonary arteries, leading to right heart pressure overload. Timely differentiation is critical as anticoagulation is contraindicated.
05.02.2025. Original article In the next Issue
First trimester placental growth factor and uterine artery pulsatility index in the prediction of preeclampsia in high-risk pregnancy

By Jasmin Hodžić, Bedrana Muračrvić, Ajna Gračić, Hana Štimjanin Hodžić, Ema Bajgorić Škrgo

Aim To identify the most effective screening method for preeclampsia by evaluating the predictive significance of measuring serum placental growth factor (PlGF) concentration and using Doppler ultrasound assessments of uterine artery blood flow during the first trimester in high-risk pregnancies as predictors of preeclampsia.
Methods A prospective screening study involving 173 high-risk pregnant women for preeclampsia, between 11 + 0 and 13 + 6 weeks of gestation was conducted. Women were divided into two groups based on pregnancy outcome: a control group of 158 pregnant women who remained normotensive, and a group of 15 high-risk pregnant women who developed symptoms of preeclampsia during pregnancy. Serum PlGF concentration using a quantitative enzyme-linked immunosorbent assay was determined.
Results PlGF level was significantly reduced in women who later developed preeclampsia (14.06 pg/mL) compared to controls (37.46 pg/mL). The uterine artery pulsatility index (UtA-PI) was significantly increased in the preeclamptic group (1.73) compared to the control group (1.44). For screening preeclampsia using the combination of PlGF and UtA-PI, the estimated detection rates were 66.67% at the fixed false-positive rate (FPR) of 5% and 73.33% at the FPR of 10%. The best screening results were obtained using regression models including maternal characteristics PlGF, and UtA-PI, yielding estimated detection rates of 73.33% at the FPR of 5% and 86.67% at the FPR of 10%, respectively.
Conclusion Placental growth factor level, in conjunction with uterine artery pulsatility index during the first trimester was a valuable and accurate biomarker for predicting preeclampsia in high-risk pregnancies. When integrated with comprehensive medical history, these markers enhance the assessment of preeclampsia risk.

05.02.2025. Original article In the next Issue
The influence of haematocrit on quality control parameters in plateletpheresis procedure

By Svetlana Jović Lacković, Sunita Delić Ćustendil, Aida Žabić, Ahida Suljkanović Mahmutović, Sabina Čamdžić Smajić, Alma Osmić Husni

05.02.2025. Original article In the next Issue
Effectiveness of ActiPatch in the management and prevention of pillar pain following open carpal tunnel release surgery in weight-bearing hand of elderly patients: an observational study

By Giulia Maria Sassara, Adriano Cannella, Ludovico Caruso, Giuseppe Taccardo, Marco Passiatore, Arturo Militerno, Maurizio Marinangeli, Rocco De Vitis

17.01.2025. Original article In the next Issue
Correlation between physical activity and acute respiratory infections in preschool children

By Melika Melunović, Mirela Lisičić-Konaković, Belma Krdžalić– Zečević, Amela Kulašević, Lejla Kurtalić

17.01.2025. Original article In the next Issue
Impact of age and body mass index on dual-energy X-ray absorptiometry scan results in postmenopausal women

By Halil Ćorović, Nusret Salkica, Naida Omerović Ćorović, Šejla Cerić, Selma Agić-Bilalagić, Amra Skopljak-Beganović, Enis Tinjak

17.01.2025. Original article In the next Issue
Efficacy and safety of a novel cost-effective suspension arthroplasty technique compared to traditional trapeziectomy with abductor pollicis longus arthroplasty Once Looped Around (OLA)/ Once Looped Inside (OLI) in basal thumb arthritis

By Giuseppe Parrone, Adriano Cannella, Giulio fioravanti Cinci, Matthew Charles Giordano, Arturo Militerno, Andra De Matthaeis, Ludovico Caruso, Rocco De Vitis

Current issue
01.09.2024. Review paper
Obesity and atherosclerosis in children

By Senka Mesihović-Dinarević

01.09.2024. Review paper
Urban thoracic trauma: diagnosis and initial treatment of non-cardiac injuries in adults

By Vasileios Leivaditis, Athanasios Papatriantafyllou, Ioanna Akrida, Michail Galanis, Emmanouil Dimopoulos, Anastasia Papaporfyriou, Benjamin Ehle, Efstratios Koletsis, Nikolaos Charokopos, George Pappas-Gogos, Francesk Mulita, Georgios-Ioannis Verras, Konstantinos Tasios, Vasiliki Garantzioti, Levan Tchabashvili, Manfred Dahm, Konstantinos Grapatsas

01.09.2024. Original article
The comparison of erector spinae plane block and caudal block for postoperative analgesia in paediatric surgery - meta-analysis

By Mahendratama Purnama Adhi, Rapto Hardian, Arif Budiman Susatya, Elizeus Elizeus, Arie Utariani

01.09.2024. Original article
Out-of-hospital cardiac arrest (OHCA) in Bosnia and Herzegovina in the period 2018 -2022: current trends, usage of automated external defibrillators (AED) and bystanders’ involvement

By Armin Šljivo, Tatjana Jevtić, Selma Terzić-Salihbašić, Arian Abdulkhaliq, Leopold Reiter, Faris Salihbašić, Ajla Bečar-Alijević, Adin Alijević, Ilma Dadić, Fatima Gavrankapetanović

01.09.2024. Original article
Predictors for major adverse cardiovascular events among patients with acute coronary syndrome in Bosnia and Herzegovina

By Namik Selimović, Amina Marić, Armin Šljivo, Aladin Altic, Irma Fajić, Lana Lekić, Azra Durak-Nalbantić

Recent issues
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22.09.2019. Review paper
Impact of hand hygiene knowledge on the hand hygiene compliance

By Martin Novák, Jozef Breznický, Jana Kompaníková, Nora Malinovská, Henrieta Hudečková

Aim
Hand hygiene practice is still burdened by inadequate compliance, whether in the professional sphere by health professionals or in the non-professional sphere by lay population. Aim of this study was to map the hand hygiene knowledge and its compliance in the monitored group of people.
Methods
The research was conducted at the Jessenius Faculty of Medicine in Martin of Comenius University in Bratislava (JFM CU) among seventy 3 rd year students of General Medicine (medical study program), and Nursing, Midwifery and Public Health (non-medical study programs). Knowledge of hygienic hand washing according to the WHO guidelines from 2009 was investigated, as well as differences in the level of microbial contamination of hands after routine hand washing between the group that had been acquainted with hand hygiene protocols and the group that had not sufficiently.
Results
The results have shown that 32.9% of the students did not perform hygienic hand washing properly. The differences between the groups of students with and without the proper hand hygiene compliance in routine hand washing were not statistically significant. Conclusion
The results of our survey have suggested that the reasons for decreased compliance with hand washing protocols may be related to forgetting to wash the hands or not being acquainted with hand washing protocols at all. The strategies focused only on one aspect of hand hygiene are, according to scientific literature, ineffective in the long term.

12.07.2020. Review paper
The effect of Aloe vera ethanol extract on the growth inhibition of Candida albicans

By Via Karina Nabila, Imam Budi Putra

22.10.2021. Review paper
Cancer rate of Bethesda category II thyroid nodules

By Francesk Mulita, Fotios Iliopoulos, Christos Tsilivigkos, Levan Tchabashvili, Elias Liolis, Charalampos Kaplanis, Ioannis Perdikaris, Ioannis Maroulis

06.11.2023. Review paper
ChatGPT's contributions to the evolution of neurosurgical practice and education: a systematic review of benefits, concerns and limitations

By Hakija Bečulić, Emir Begagić, Rasim Skomorac, Anes Mašović, Edin Selimović, Mirza Pojskić

12.07.2020. Review paper
Epidemiology of injuries connected with dance: a critical review on epidemiology

By Giuseppe Rinonapoli, Marta Graziani, Paolo Ceccarini, Cristina Razzano, Francesco Manfreda, Auro Caraffa

The aim of this review was to identify all types of injuries connected to the gestures of dancers and understand the associated biomechanical patterns. This is the first step in the definition of a prevention program that lacks in this kind of athletic activity. A search of Medline/PubMed, EMBASE, and the Cochrane database from 1990 to 2019 using the search terms ‘‘dance and injuries’’ and ‘‘dance and injuries and epidemiology’’ initially resulted in 601 citations. A total of 16 articles were eligible for a review. All health problems that lead to stop the activity of a dancer are classified as "dancer's injuries". They were divided in acute and overuse injuries, the first being traumatic and the latter ones microtraumatic. The anatomical region most affected by injuries in dance was clearly the ankle and foot. It can be inferred that professional and
pre-professional dancers had a higher prevalence of back injuries in comparison to amateur dancers, while amateurs suffered more frequently from hip/groin/thigh injuries. Doctors, teachers, sport trainers and dancers themselves, all those who contribute to the dancer's performance, should know the most prevalent dancers’ injuries. Moreover, they should know the prevention procedures, in order to minimize the risk of injury and recurrences.

01.09.2024. Review paper
Obesity and atherosclerosis in children

By Senka Mesihović-Dinarević

12.07.2020. Review paper
Combination of vitamin A and D supplementation for ischemic stroke: effects on interleukin-1ß and clinical outcome

By Alfansuri Kadri, Hasan Sjahrir, Rosita Juwita Sembiring, Muhammad Ichwan

01.09.2024. Original article
Predictors for major adverse cardiovascular events among patients with acute coronary syndrome in Bosnia and Herzegovina

By Namik Selimović, Amina Marić, Armin Šljivo, Aladin Altic, Irma Fajić, Lana Lekić, Azra Durak-Nalbantić

01.09.2024. Review paper
Urban thoracic trauma: diagnosis and initial treatment of non-cardiac injuries in adults

By Vasileios Leivaditis, Athanasios Papatriantafyllou, Ioanna Akrida, Michail Galanis, Emmanouil Dimopoulos, Anastasia Papaporfyriou, Benjamin Ehle, Efstratios Koletsis, Nikolaos Charokopos, George Pappas-Gogos, Francesk Mulita, Georgios-Ioannis Verras, Konstantinos Tasios, Vasiliki Garantzioti, Levan Tchabashvili, Manfred Dahm, Konstantinos Grapatsas

This comprehensive review aims to delineate the prevailing non-cardiac thoracic injuries occurring in urban environments following initial on-site treatment and subsequent admission to hospital emergency departments. Our study involved a rigorous search within the PubMed database, employing key phrases and their combinations, including "thoracic injury," "thoracic trauma," "haemothorax," "lung contusion," "traumatic pneumothorax," "rib fractures," and "flail chest." We focused on original research articles and reviews. Non-cardiac thoracic injuries exhibit a high prevalence, often affecting poly-trauma patients, and contributing to up to 35% of polytrauma-related fatalities. Furthermore, severe thoracic injuries can result in a substantial 5% mortality rate. This review provides insights into clinical entities such as lung contusion, traumatic haemothorax, pneumothorax, rib fractures, and sternal fractures. Thoracic injuries represent a frequent and significant clinical concern for emergency department physicians and thoracic surgeons, warranting thorough understanding and timely intervention.

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