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Edited by:

Selma Uzunović

Vol 22, No 1 (2025):

Medicinski Glasnik

Published: 03.02.2025.

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01.08.2025. Original article In the next Issue
Quality of life among adults with hearing loss in Cantonal Hospital of Zenica: A cross-sectional study

By Amel Krkalić, Admir Keserovic, Harun Selimović, Harun Mandra, Anes Jogunčić, Ragib Pugonja

Aim To assess Qualitiy of life (QoL) in adults by comparing two groups, the one with diagnosed hearing loss (HL) and the other without hearing complaints.

Methods This cross-sectional study included 110 consecutive voluntary adult  patients divided in two groups: patients with hearing loss and control group. All participants , after examination , answered to a questionnaires on sociodemographic, clinical data and the World health Organization Quality of Life- Short version (WHOQOL-BREF).

Results: Among 110 adults  participants, 59  were with hearing loss (hearing loss group – HLG) and 19  in hearing loss  with hearing aid group (HLHAG) and 51 in control group.  Consistently  higher score  in the domains of physical health (p=0.036) and psychological health (p=0.024) in control group was found; other domains did not reach statistical significance Significant differences between the HLHAG and control group in physical health (mean difference = -11.3; p=0.036) and psychological health (mean difference = -11.3; p=0.029) was confirmed.

Conculsion Hearing loss could decrease QoL. Therefore, it is very important to recognize hearing impairment in a timely manner and to take a serious approach to treatment.

01.08.2025. Original article Translational and Clinical Research In the next Issue
Comparison of coronary artery calcium scores between patients with and without type 2 diabetes

By Mirza Babić, Zarina Babić Jušić, Sabina Prevljak, Fuad Zukić, Minela Bećirović, Amir Bećirović, Admir Abdić, Emir Bećirović

ABSTRACT

Aim This study compared the extent of coronary artery calcification in patients with and without type 2 diabetes mellitus (T2DM) using Coronary Computed Tomography Angiography (CCTA).

Methods This retrospective, observational cohort study included 107 patients who underwent CCTA at the Clinical Centre of the University of Sarajevo between July and December 2024. Patients were divided into two groups: those with T2DM (n=51) and those without T2DM (n=56). Laboratory parameters, demographic data, and calcium scores were analysed. The calcium score was categorised into six groups based on cardiovascular risk and the comparison was made using appropriate statistical analysis.

Results Patients with T2DM had significantly higher calcium scores than non-diabetic patients (p=0.0001). In the T2DM group, 35.3% of patients had a calcium score >400, indicating high cardiovascular risk. Patients without diabetes were more frequently classified into lower-risk categories (p=0.0001). A significant correlation was found between calcium score and age (r=0.442, p=0.001) and gender (r=-0.218, p=0.024), with men having higher calcium scores. Additionally, total cholesterol, LDL, and uric acid levels were significantly higher in diabetic patients (p=0.005; p=0.025; p=0.03, respectively).

Conclusion This study confirms a strong association between T2DM and increased coronary artery calcification. Age and male gender are significant predictors of higher calcium scores. Further research is needed to explore these relationships, particularly within the Bosnian population.

Keywords Coronary angiography, coronary artery calcification, coronary disease, diabetes mellitus type 2

01.08.2025. Original article Translational and Clinical Research In the next Issue
Association of Botulinum toxin treatment due to aesthetic corrections in the face with the level of happiness, anxiety and depression

By Omar Suljagić, Emir Tupković, Kenana Ljuca, Faris Suljagić, Nadina Ljuca

Aim Any aesthetic procedure in the head and/or in the face might have an impact on psychological status of the treated participants. Aim of this study was to investigate whether Botulinum toxin treatment for aesthetic purpose in the face influences on the level of happiness, depression and anxiety.

Methods This prospective cohort observational study included 30 participants, who were treated by botulinum toxin (Botox) due to aesthetic corrections. The treatment included laugh lines, frown lines and horizontal forehead lines. Preprocedural, three and six months after the treatment the participants were assessed by The Oxford Happiness Questionnaire (OHQ), The Beck Depression Inventory (BDI) and The Beck Anxiety Inventory (BAI) to determine the level of happiness, anxiety and depression was used.

Results Three months after the treatment by Botox the level of happiness was significantly increased (5.26±0.43 vs 4.3±0.34; p<0.0001). The levels of depression (7.6±6.0 vs 14.2±8.3; p<0.0001) and anxiety (8.8±6.3 vs 16.4±8.8; p<0.0001) were significantly decreased compared with preprocedural level. Significant increased level of happiness and decreased levels of depression and anxiety remained six months after the treatment, but attenuated. A dose of applied botulinum toxin was negatively correlated with the level of depression (r = -0.394; p=0.0421) and anxiety (r = -0.387; p=0.0302).

Conclusion Botulinum toxin treatment for aesthetic purpose in the face positively influences psychological status of the treated individual in the short-therm.

01.08.2025. Original article Pathology In the next Issue
Correlation of Ki67 expression with estrogen receptor (ER) and progesterone receptor (PR) status in breast cancer

By Dedy Hermansyah, Muhammad Al Anas, Kania Haura Chalisaturahmi, Mutiara Baitina, Karina Sugih Arto, Endi Taris Pasaribu

01.08.2025. Original article Translational and Clinical Research In the next Issue
Prognostic significance of CD163 expression in colorectal cancer stroma: a retrospective cohort study

By Nauryzbay Imanbayev, Yerbolat Iztleuov, Arip Koyshybaev, Aigul Zhumasheva, Beibit Baizakov, Nurgul Kereyeva, Zhanna Satenova, Aigerim Imanbayeva, Anara Tulyayeva, Dinara Zholmukhamedova, Marzhan Aitmagambetova, Azamat Zharylgapov

01.08.2025. Original article Translational and Clinical Research In the next Issue
Role of postoperative serum thyroglobulin as a prognostic factor for the outcome of radioactive iodine therapy of follicular thyroid cancer.

By selma Agić-Bilalagić, Šejla Cerić, Amela Begić, Azra Durak-Nalbantić, Edina Đozić, Timur Cerić

01.08.2025. Systematic review Pharmacology In the next Issue
Fixed-dose combination antihypertensives in patients with chronic kidney disease: A systematic literature review

By Vedad Herenda, Selma Jusufović, Adnan Musanović

Current issue
03.02.2025. Editorial
Bariatric surgery in University Clinical Centre Tuzla and Bosnia and Herzegovina: where we are and where we want to be

By Fuad Pašić, Nermin Salkić, Emir Ahmetašević, Ervin Alibegović, Jasmina Smajić, Lejla Jašarević, Rusmir Softić, Jasmin Hamidović, Amina Krupalija

03.02.2025. Original article
The influence of haematocrit on quality control parameters in plateletpheresis procedure

By Svetlana Jović Lacković, Sunita Delić Ćustendil, Aida Žabić, Ahida Suljkanović Mahmutović, Sabina Čamdžić Smajić, Alma Osmić Husni

03.02.2025. Original article
Hypoxia-conditioned mesenchymal stem cells (MSC) exosomes attenuate ultraviolet-B (UVB)-mediated malondialdehyde (MDA) and matrix metalloproteinase-1 (MMP)-1 upregulation in collagen loss models

By Jessica Angelina, Agung Putra, Setyo Trisnadi, Dedy Hermansyah, Eko Setiawan, Titiek Sumarawati, Nur Dina Amalina

03.02.2025. Original article
The Effect of Arabic Gum on Gentamicin Nephrotoxicity in Mice: A Pathological Study

By Liqaa Alhyali, Firas Abed, Entisar AL-Kenanny

03.02.2025. Original article
Heart and kidney crosstalk: risk factors, clinical features, and short-term outcomes associated with acute kidney injury in patients suffering acute non-ST elevation myocardial infarction

By Minela Becirovic, Emir Bećirović, Semir Hadžić, Lejla Rakovac Tupković, Amir Bećirović, Nadina Avdić Jahić, Aida Ribić, Lamija Ferhatbegović, Amira Jagodić Ejubović, Emir Begagić, Daniela Lončar, Kenana Ljuca

Recent issues
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Most read
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22.09.2019. Review paper
Impact of hand hygiene knowledge on the hand hygiene compliance

By Martin Novák, Jozef Breznický, Jana Kompaníková, Nora Malinovská, Henrieta Hudečková

Aim
Hand hygiene practice is still burdened by inadequate compliance, whether in the professional sphere by health professionals or in the non-professional sphere by lay population. Aim of this study was to map the hand hygiene knowledge and its compliance in the monitored group of people.
Methods
The research was conducted at the Jessenius Faculty of Medicine in Martin of Comenius University in Bratislava (JFM CU) among seventy 3 rd year students of General Medicine (medical study program), and Nursing, Midwifery and Public Health (non-medical study programs). Knowledge of hygienic hand washing according to the WHO guidelines from 2009 was investigated, as well as differences in the level of microbial contamination of hands after routine hand washing between the group that had been acquainted with hand hygiene protocols and the group that had not sufficiently.
Results
The results have shown that 32.9% of the students did not perform hygienic hand washing properly. The differences between the groups of students with and without the proper hand hygiene compliance in routine hand washing were not statistically significant. Conclusion
The results of our survey have suggested that the reasons for decreased compliance with hand washing protocols may be related to forgetting to wash the hands or not being acquainted with hand washing protocols at all. The strategies focused only on one aspect of hand hygiene are, according to scientific literature, ineffective in the long term.

12.07.2020. Review paper
The effect of Aloe vera ethanol extract on the growth inhibition of Candida albicans

By Via Karina Nabila, Imam Budi Putra

22.10.2021. Review paper
Cancer rate of Bethesda category II thyroid nodules

By Francesk Mulita, Fotios Iliopoulos, Christos Tsilivigkos, Levan Tchabashvili, Elias Liolis, Charalampos Kaplanis, Ioannis Perdikaris, Ioannis Maroulis

12.07.2020. Review paper
Epidemiology of injuries connected with dance: a critical review on epidemiology

By Giuseppe Rinonapoli, Marta Graziani, Paolo Ceccarini, Cristina Razzano, Francesco Manfreda, Auro Caraffa

06.11.2023. Review paper
ChatGPT's contributions to the evolution of neurosurgical practice and education: a systematic review of benefits, concerns and limitations

By Hakija Bečulić, Emir Begagić, Rasim Skomorac, Anes Mašović, Edin Selimović, Mirza Pojskić

Aim
This study provides a comprehensive review of the current literature on the use of ChatGPT, a generative Artificial Intelligence (AI) tool, in neurosurgery. The study examines potential benefits and limitations of ChatGPT in neurosurgical practice and education.
Methods
The study involved a systematic review of the current literature on the use of AI in neurosurgery, with a focus on
ChatGPT. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed to ensure a comprehensive and transparent review process. Thirteen studies met the inclusion criteria and were included in the final analysis. The data extracted from the included studies were analysed and synthesized to provide an overview of the current state of research on the use of ChatGPT in neurosurgery.
Results
The ChatGPT showed a potential to complement and enhance neurosurgical practice. However, there are risks and limitations associated with its use, including question format limitations, validation challenges, and algorithmic bias. The study highlights the importance of validating machine-generated content for accuracy and addressing ethical concerns associated with AI technologies. The study also identifies potential benefits of ChatGPT, such as providing personalized treatment plans, supporting surgical planning and navigation, and enhancing large data processing efficiency and accuracy.
Conclusion
The integration of AI technologies into neurosurgery should be approached with caution and careful consideration of
ethical and validation issues. Continued research and development of AI tools in neurosurgery can help us further understand their potential benefits and limitations. 

02.07.2022. Review paper
Obstetric shock and shock in obstetrics – steady obstetrical syndrome

By Anis Cerovac, Dubravko Habek, Elmedina Cerovac, Jasna Čerkez Habek

01.09.2024. Review paper
Obesity and atherosclerosis in children

By Senka Mesihović-Dinarević

12.07.2020. Review paper
Combination of vitamin A and D supplementation for ischemic stroke: effects on interleukin-1ß and clinical outcome

By Alfansuri Kadri, Hasan Sjahrir, Rosita Juwita Sembiring, Muhammad Ichwan

01.09.2024. Original article
Predictors for major adverse cardiovascular events among patients with acute coronary syndrome in Bosnia and Herzegovina

By Namik Selimović, Amina Marić, Armin Šljivo, Aladin Altic, Irma Fajić, Lana Lekić, Azra Durak-Nalbantić

Aim Despite advancements in the diagnosis, treatment and monitoring of patients with acute coronary syndrome (ACS), morbidity and mortality following ACS remain high. The aim of this study was to actively seek possible predictors of adverse outcomes after ACS aiming to identify high-risk patients promptly.
Methods This retrospective cohort study investigated patients with ACS hospitalized at Clinical Centre of the University of Sarajevo from 2019 to 2021. Patients were followed up for a period of 12 months post-discharge to assess major cardiovascular events (MACE) and MACE associated independent predictors. 
Results. The study included 121 patients, mostly male 102 (84.3%), with a mean age of 60.83±12.61 years; prevalent risk factors were hypertension 94 (77.7%), dyslipidaemia 84 (69.4%), diabetes mellitus 91 (75.2%), active smoking 67 (55.4%) and positive family history of cardiovascular diseases 81 (66.9%). MACE occurred in 33 (27.3%) patients since the initial ACS, and those patients were older (p=0.012), had higher level of creatinine (p<0.001), lower ejection fraction at discharge (p<0.001) and larger left atrial diameter (p=0.032). Serum creatinine (OR=1.014, 95% CI 1,003-1,026, p=0.017) and ejection fraction (OR=0.924, 95% CI 0,869-0,984, p=0.013) were independent predictors associated with a 12-month follow up MACE following ACS.
Conclusion A monitoring of serum creatinine level, left atrial diameter, and ejection fraction post-acute coronary syndrome as potential indicators of future MACE within a 12-month follow-up period is of great importance. These findings emphasize the need for tailored management strategies to mitigate risks in this patient population.

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