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Internal Medicine Clinic, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina
Internal Medicine Clinic, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina
School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
Department of Clinical Pharmacology, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina
Internal Medicine Clinic, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina
Internal Medicine Clinic, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina
Department of Pediatrics, General Hospital "Prim. Dr. Abdulah Nakaš", Sarajevo, Bosnia and Herzegovina
Department of Internal Medicine with Haemodialysis, Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina
Department of Internal Medicine with Haemodialysis, Cantonal Hospital Zenica, Zenica, Bosnia and Herzegovina
Department of General Medicine, School of Medicine, University of Zenica, Zenica, Bosnia and Herzegovina
Internal Medicine Clinic, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina
Health Centre of Sarajevo Canton, Sarajevo, Bosnia and Herzegovina
Aim Acute kidney injury (AKI) presents a high mortality complication in patients with acute myocardial infarction (AMI). Yet, its correlation with non-ST elevation myocardial infarction (NSTEMI) remains neglected in the literature. This study aims to investigate the prevalence, risk factors, clinical features, and short-term outcomes associated with AKI development in patients with acute NSTEMI.
Methods A one-year prospective observational cohort study involved 170 consecutive patients hospitalized in the Intensive Care Department of the Internal Medicine Clinic at the University Clinical Centre Tuzla diagnosed with acute NSTEMI. Patients were subsequently categorized into AKI and non-AKI groups based on AKI development within 48 hours. Demographic characteristics, laboratory findings, and short-term clinical outcomes were compared between the groups.
Results Of 170 patients, 31 (18.2%) developed AKI within 48 hours of acute NSTEMI. Significant age differences, blood urea nitrogen (BUN), creatinine, estimated glomerular filtration rate (eGFR), blood glucose level (BGL), C-reactive protein (CRP), and high sensitivity (hs) troponin were observed, making patients with lower baseline kidney function, more extensive myocardial infarction, and a heavier systemic inflammatory response following acute NSTEMI more susceptible to AKI development. In the follow-up period, mortality rates were significantly higher in the AKI group, amounting to 35.5% compared to 10.1% in the non-AKI group. Additionally, mortality increased with the severity of AKI, reaching 100% in AKI stage 2.
Conclusion This study highlights demographic, clinical and laboratory findings in patients with acute NSTEMI, which contribute to AKI development. Early detection and tailored interventions are crucial in mitigating AKI-associated morbidity and mortality.
No specific funding was received for this study
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