×
Home Current Archive Editorial board
News Contact
Original article

This is an early access version

Effect of Arabic Gum on Gentamicin Nephrotoxicity in Mice: A Pathological Study

By
Liqaa Alhyali ,
Liqaa Alhyali
Contact Liqaa Alhyali

Department of Pathology, College of Medicine, University of Mosul, Mosul, Iraq

Firas Abed ,
Firas Abed

Department of Pathology and Poultry Diseases, College of Veterinary Medicine, University of Mosul, Mosul, Iraq

Entisar AL-Kenanny
Entisar AL-Kenanny

Dentistry College, Al-Iraqia University, Baghdad, Iraq

Editor: SELMA UZUNOVIĆ

Abstract

Aim To investigate the effect of Arabic gum on gentamycin nephrotoxicity in mice kidney.
Methods Forty (40) mice were divided into five groups, eight mice in each. Group one (G1) stands for the negative control group. The second one (G2) was injected with gentamycin only, while the third one (G3) was given an Arabic gum orally 10g/kg. The 4th group (G4) was injected with gentamycin for 8 days, and then followed by Arabic gum orally for 8 days. The fifth group (G5) was injected with gentamycin plus oral administration of Arabic gum at the same time. A scoring system (+1-+4) was used to grade the histological features in the kidneys.
Results The results revealed a significant increase in body weight in G3 group only; this group presented a significant decrease in the level of both urea and creatinine. Group G2 showed a marked elevation in both serum urea and creatinine. Acute tubular necrosis (+4), in both G2 and G5. In G3, kidney sections presented mild cell swelling of the tubular epithelium in addition to the normal architectures (score +1), while G4 sections revealed tubular hyalin cast, expansion of glomerular tufts.
Conclusion The research indicates that gentamycin leads to kidney damage in mice. Arabic gum could be a treatment option although additional studies are required to determine the best dosing and timing, for optimal effectiveness.

Author Contributions

Conceptualization, L.A. and F.A.; Data curation, L.A.; Formal Analysis, L.A.; Funding acquisition, L.A.; Methodology, L.A.; Resources, L.A.; Supervision, L.A. and F.A.; Validation, L.A. and F.A.; Writing – original draft, L.A.; Visualization, F.A.; Writing – review & editing, F.A.; Investigation, E.A.; Project administration, E.A.; Software, E.A. All authors have read and agreed to the published version of the manuscript.

Citation

Funding Statement

No specific funding was received for this study.

Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

 

Article metrics

Google scholar: See link

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.