Original article

In vitro effectiveness of the avocado peel extract (Persea americana Mill) as an antifungal against Trichophyton rubrum, the cause of dermatophytosis

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Abstract

Aim: To determine the effectiveness of avocado peel extract (Persea americana Mill) as an antifungal against T. rubrum, which causes dermatophytosis.

Methods: In vitro laboratory experimental study using a post-testonly control group design analysed active compounds of avocado peel and continued with the antifungal activity test. In each group divided according to the concentration of 0% (negative control), 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, and positive control (2% ketoconazole) antifungal activity test was carried out using the fungus T. rubrum ATCC 28188 for five repetitions.

Results: The avocado peel extract contained phenolic compounds, flavonoids, tannins, saponins, alkaloids, terpenoids, and glycosides. Antifungal activity test showed a significant difference with the highest mean inhibition zone diameter of T. rubrum, which was demonstrated at a concentration of 75%.

Conclusion: Avocado peel extract is useful to inhibit growth of Trichophyton rubrum in dose dependent.

Keywords: avocado peel, dermatophytosis, Persea americana Mill., Trichophyton rubrum

How to Cite:

Yosi, A., Armayanti, I. & Wardani, M. K., (2023) “In vitro effectiveness of the avocado peel extract (Persea americana Mill) as an antifungal against Trichophyton rubrum, the cause of dermatophytosis”, Medicinski glasnik 20(2), 196-201. doi: https://doi.org/10.17392/1587-23