Hypoxic mesenchymal stem cells (MSCS)-induced interleukin (IL)-10 alleviate systemic lupus erythematosus (SLE) infl ammation through inhibiting interferon (IFN)-gamma production
Aim To determine the eff ect of hypoxic mesenchymal stem cells (MSCs) on the interleukin (IL)-10 and interferon (IFN)-gamma in peripheral blood mononuclear cells (PBMCs) from systemic lupus erythematosus (SLE) patients.Methods This study used a post-test control group design. Hypoxic MSCs were isolated and characterized according to their surface m...
By Yan Wisnu Prajoko, Agung Putra, Ardi Prasetio, Nur Dina Amalina
Hypoxic secretome mesenchymal stem cells inhibiting interleukin-6 expression prevent oxidative stress in type 1 diabetes mellitus
Aim Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the chronic inflammation of the pancreatic islets of Langerhans. Hyperglycaemia leads to suppressed antioxidant enzyme and increased inflammation in the pancreatic cell, resulting in pancreatic cell death. Hypoxic secretome mesenchymal stem cells (HS-MSCs) are soluble mol...
By Ayuningtyas Utami, Agung Putra, Joko Wahyu Wibowo, Amalina Nur Dina, Risky Chandra Satria Irawan
The role of mesenchymal stem cells in allergic rhinitis and its relationship with IL-10, plasma cells and regulatory T cells
Aim Allergic rhinitis (AR) is an IgE-mediated inflammation of the nose. Regulatory T cells (Tregs), plasma cells and inflammatory cytokines have shown to play a critical role in allergic airway inflammation. The aim of the study was to investigate the role of mesenchymal stem cells (MSCs) in generating Treg cells and plasma cells associated with re...
By Delfitri Munir, Iqbal Pahlevi Nasution, Lia Restimulia, Agung Putra, Nur Dina Amalina
Red algae extract suppresses caspase-3 gene expression and induces catalase antioxidant enzyme in testicles of rats induced by boric acid
Aim To determine the effect of red algae extract on the gene expression of catalase and caspase-3 in testicules of rats induced by boric acid (BA).Methods This is experimental research with post-test control group design. Twenty four healthy male Wistar rats were divided intofour treatment groups: a healthy group, negative control group, two treatm...
By Ayu Renda Sari, Joko Wahyu Wibowo, Sri Priyantini, Agung Putra, Nur Dina Amalina
Clitorea ternatea flower extract induces platelet-derived growth factor (PDGF) and GPx gene overexpression in ultraviolet (UV) B irradiationinduced collagen loss
Aim To determine the effect of Clitorea ternatea flower extract (CTFE) in the gel dosage form on the expression of GPx and platelet-derived growth factor (PDGF) in ultraviolet (UV) - B irradiation-induced collagen loss rat model.Methods This is experimental research with post-test control group design. Twenty healthy male Wistar rats were divided i...
By Rizka Sofyanti Putri, Agung Putra, Dr Chodidjah, Dewi Masyitah Darlan, Setyo Trisnadi, Siti Thomas, Nur Dina Amalina, Rizky Candra Irawan
Secretome of hypoxia-preconditioned mesenchymal stem cells enhance the expression of HIF-1a and bFGF in a rotator cuff tear model
Aim To determine the effect of secretome hypoxia mesenchymal stem cells (SH-MSCs) on the relative gene expression of hypoxia inducible factor-1a (HIF-1a) and basic fibroblast growth factor (bFGF) in accelerating histomorphometric repair of tendon to bone interface healing in rats acute rotator cuff tear (RCT) model.Methods This is experimental rese...
By Meiky Fredianto, Herry Herman, Yoyos Dias Ismiarto, Agung Putra, Iffan Alif, Nur Dina Amalina, Muhammad Ariq Nazar
Revealing the decrease of indoleamine 2,3-dioxygenase as a major constituent for B cells survival post-mesenchymal stem cells co-cultured with peripheral blood mononuclear cell (PBMC) of systemic lupus erythematosus (SLE) patients
Aim Mesenchymal stem cells (MSCs) have potent immunosuppressive properties to control systemic lupus erythematosus (SLE) disease by inhibiting indoleamine 2,3-dioxygenase (IDO), and increasing regulatory T cells (Treg) to control innate and adaptive immune cells. However, the interaction and mechanism regarding IDO and B cells in the co-culture of ...
By Dewi Masyithah Darlan, Delfitri Munir, Agung Putra, Iffan Alif, Nur Dina Amalina, Nelva Karmila Jusuf, Imam Budi Putra
Rats’ umbilical-cord mesenchymal stem cells ameliorate mast cells and Hsp70 on ovalbumin-induced allergic rhinitis rats
Aim Allergic rhinitis (AR) is a heterogeneous condition that has been associated with inflammatory responses and is characterized by clinical typical symptoms of nasal itching, sneezing, watery discharge and congestion. Mesenchymal stem cells (MSCs) are multipotent stem cells that have the immunoregulatory ability by secreting various cytokines whi...
By Lia Restimulia, Syafruddin Ilyas, Delfitri Munir, Agung Putra, Teti Madiadipoera, Farhat Farhat, Rosita Juwita Sembiring, Muhammad Ichwan, Nur Dina Amalina
Mesenchymal stem cells under hypoxia condition inhibit peritoneal adhesion by suppressing the prolonged release of interleukin-6
Aim To investigate the role of hypoxia-preconditioned mesenchymal stem cells (H-MSCs) in preventing peritoneal adhesionby regulating IL-6 at days 6 and 12.Methods Twenty-four PAs rat model weighing 250 g to 300 g were randomly allocated into 4 groups: sham (Sh), control (C),H-MSCs treatment group at dose 1.5 x 106 (T1) and 3 x 106 (T2). To in...
By Adi Muradi Muhar, Agung Putra, Vito Mahendra Ekasaputra, Dewi Masyithah Darlan, Desiree Anggia Paramita, Iqbal Pahlevi Adeputra Nasution
Anti-fibrotic effect of intravenous umbilical cord-derived mesenchymal stem cells (UC-MSCs) injection in experimental rats induced liver fibrosis
Aim To investigate the effect of umbilical cord-derived mesenchymal stem cells (UC-MSCs) administration among liverfibrosis experimental rat model via the regulation of angiotensin II type 1 receptor (AT1R) and platelet-derived growth factor-β (PDGF-β) due to their therapeutic potential to replace liver transplantation for advanced liver ...
By Taufik Sungkar, Agung Putra, Dharma Lindarto, Rosita Juwita Sembiring