Original article

Clinicopathological Characteristics of Young-Onset Breast Cancer Patients Stratified by Molecular Subtypes at H. Adam Malik Hospital

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Abstract

Aim: To examine and evaluate the clinicopathological characteristics of young-onset breast cancer across molecular subtypes in patients from Southeast Asia, with a specific focus on those treated at H. Adam Malik Hospital, Indonesia.

Methods: A descriptive observational study with a cross-sectional design was conducted on medical records of breast cancer patients aged <40 years treated at H. Adam Malik Hospital from January 2017 to December 2022. Data included demographic, clinical, histopathological, and immunohistochemical findings. Statistical analyses were performed descriptively.

Results: Among the 104 patients analyzed, 71 (69.2%) had T4 tumors, and 49 (47.1%) had NST-type tumors. Most cases lacked ER (72, 69.2%) and PR (71, 68.3%) expression. A total of 41 patients had poorly differentiated tumors, with the majority at stage IV. The HER-2 positive subtype was most common (39, 37.5%), followed by Luminal B (31, 29.8%) and TNBC (22, 21.2%).

Conclusion: Young-onset breast cancer at H. Adam Malik Hospital predominantly features advanced stages, aggressive histopathological grades, and a high prevalence of HER2-positive and Luminal B subtypes. These findings highlight the importance of early detection and personalized treatment approaches.

Keywords: molecular subtypes, cross-sectional studies, Breast Cancer, young adult, medical records

How to Cite:

Pratama, R. D., Hermansyah, D. & Pohan, P. U., (2025) “Clinicopathological Characteristics of Young-Onset Breast Cancer Patients Stratified by Molecular Subtypes at H. Adam Malik Hospital”, Medicinski glasnik 22(2), 263-267. doi: https://doi.org/10.17392/1942-22-02