Serum homocysteine levels in patients with probable vascular dementia
- Salem Alajbegović
(Cantonal Hospital, Zenica, Zenica, Department of Endocrinology and Diabetes, Bosnia and Herzegovina)
- Orhan Lepara (School of Medicine, University of Sarajevo, Sarajevo, Department of Human Physiology, Bosnia and Herzegovina)
- Almira Hadžović-Džuvo (School of Medicine, University of Sarajevo, Sarajevo, Department of Human Physiology, Bosnia and Herzegovina)
- Alma Mutevelić-Turković (School of Medicine, University of Sarajevo, Sarajevo, Department of Human Physiology, Bosnia and Herzegovina)
- Lejla Alajbegović (Representative office of Berlin-Chemie AG in Sarajevo, Sarajevo, Bosnia and Herzegovina)
- Asija Zaćiragić (School of Medicine, University of Sarajevo, Sarajevo, Department of Human Physiology, Bosnia and Herzegovina)
- Nesina Avdagić (School of Medicine, University of Sarajevo, Sarajevo, Department of Human Physiology, Bosnia and Herzegovina)
- Amina Valjevac (School of Medicine, University of Sarajevo, Sarajevo, Department of Human Physiology, Bosnia and Herzegovina)
- Nermina Babić (School of Medicine, University of Sarajevo, Sarajevo, Department of Human Physiology, Bosnia and Herzegovina)
- Amela Dervišević (School of Medicine, University of Sarajevo, Sarajevo, Department of Human Physiology, Bosnia and Herzegovina)
Abstract
Aim: To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD.
Methods: Serum concentration of tHcy was determined by the Fluorescence Polarization Immunoassay on the AxSYM System. Cognitive impairment was tested by the Mini Mental Status Examination (MMSE) score. Body mass index (BMI) was calculated for each subject included in the study.
Results: Age, systolic, diastolic blood pressure and BMI did not differ significantly between the two groups. Mean serum tHcy concentration in the control group of subjects was 13.35 µmol/L, while in patients with probable VD it was significantly higher, 19.45 µmol/L (p=0.002). A negative but insignificant association between serum tHcy concentration and cognitive impairment in patients with probable VD was found.
Conclusion: Increased tHcy concentration in patients with probable VD suggests the possible independent role of Hcy in the pathogenesis of VD.
Keywords: neurotoxicity, cognitive impairment, Mini-Mental State Examination
How to Cite:
Alajbegović, S., Lepara, O., Hadžović-Džuvo, A., Mutevelić-Turković, A., Alajbegović, L., Zaćiragić, A., Avdagić, N., Valjevac, A., Babić, N. & Dervišević, A., (2017) “Serum homocysteine levels in patients with probable vascular dementia”, Medicinski glasnik 14(2), 257-261. doi: https://doi.org/10.17392/916-17
Downloads:
Download PDF
View PDF
0 Views
0 Downloads