Effectiveness of teriparatide combined with the Ilizarov technique in septic tibial non-union
- Giuseppe Rollo
(Vito Fazzi Hospital, Lecce, Department of Orthopaedics and Traumatology, Italy)
- Francesco Luceri (Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Ortopedico Galeazzi, Milan, Italy)
- Gabriele Falzarano (AORN SAN PIO “Gaetano Rummo Hospital”, Benevento, Department of Orthopaedics and Traumatology, Italy)
- Carlo Salomone (Malattie Infettive Osteo-Articolari MIOS, S. Maria di Misericordia Hospital, Savona, Italy)
- Enrico Maria Bonura (Poliambulanza Foundation Hospital, Brescia, Department of Orthopaedics and Traumatology, Italy)
- Dmitry Popkov (Russian Ilizarov Scientific Centre “Reconstructive Traumatology and Orthopaedics”, Kurgan, Russia)
- Mario Ronga (University of Molise, Campobasso, Department of Medicine and Health Sciences 'Vincenzo Tiberio', Italy)
- Giuseppe Pica (AORN SAN PIO “Gaetano Rummo Hospital”, Benevento, Department of Orthopaedics and Traumatology, Italy)
- Michele Bisaccia (University of Perugia, “S. Maria della Misericordia” Hospital, Perugia, Division of Orthopaedics and Trauma Surgery, Italy)
- Valentina Russi (Vito Fazzi Hospital, Lecce, Department of Orthopaedics and Traumatology, Italy)
- Predrag Grubor (School of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina)
- Raffaele Franzese (Orthopaedics and Traumatology Unit, Villa del Sole Caserta, Caserta, Caserta, Italy)
- Giuseppe M. Peretti (Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Ortopedico Galeazzi, Milan, Italy)
- Luigi Meccariello (AORN SAN PIO “Gaetano Rummo Hospital”, Benevento, Department of Orthopaedics and Traumatology, Italy)
Abstract
Aim: The septic non-union is a common compliance in bone healing due to bone infection. Bone resection, associated with Ilizarov osteo-distraction technique, is commonly used in these cases. The aim of this study was to analyse clinical and radiological results of teriparatide in combination with the Ilizarov technique and to compare this treatment with the standard treatment.
Methods: Forty adult patients underwent surgery because of type C of the Association for the Study and Application of
Methods: of Ilizarov (ASAMI) classification non-union were enrolled. The patients were divided in two groups: those treated with Ilizarov technique (Norm group) and those treated with Ilizarov technique combined with teriparatide injection (Teri group). Surgical duration, complication rate, bone healing status, clinical and functional outcomes were assessed according to the A.S.A.M.I. classification in the mean follow-up of 12 months. The subjective quality of life was assessed by the Short Form Survey (SF)-12.
Results: Teri group showed less time wearing Ilizarov's frame (p<0.05) than the Norm group and a statistical significance in the inter-rater reliability Cohen’s k (p>0.05) respect to Norm according the score between the bone healing and clinical outcome results. There was no statistically significant difference between the two groups in other parameters that were assessed.
Conclusion: A benefit of teriparatide was found as adjuvant in the treatment of septic non-union.
Keywords: bone regeneration, Ilizarov technique, teriparatide, tibia, limb salvage, osteomyelitis
How to Cite:
Rollo, G., Luceri, F., Falzarano, G., Salomone, C., Bonura, E. M., Popkov, D., Ronga, M., Pica, G., Bisaccia, M., Russi, V., Grubor, P., Franzese, R., Peretti, G. M. & Meccariello, L., (2020) “Effectiveness of teriparatide combined with the Ilizarov technique in septic tibial non-union”, Medicinski glasnik 18(1), 287-292. doi: https://doi.org/10.17392/1280-21
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