Original article

Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina

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Abstract

Aim: To investigate association of two LPIN1 gene variations with main traits of metabolic syndrome (MS) (waist circumference, body mass index, blood pressure, triglycerides, HDL-cholesterol and fasting glucose levels) in population from Bosnia and Herzegovina.

Methods: This study included 43 patients with metabolic syndrome and 43 healthy controls from General Hospital in Tešanj, Bosnia and Herzegovina. Subjects were genotyped for two LPIN1 gene variations (rs11693809: C>T and rs2716610: C>T) by real time PCR method.

Results: In control subjects LPIN1 polymorphism, rs2716610: C>T, was significantly associated with a lower body mass index (BMI) (p=0.008) and waist circumference (p=0.008). The second analyzed rs11693809: C>T polymorphism was associated with lower blood HbA1c levels (p=0.048) in a group of MS patients.

Conclusion:

Results: of our study suggest that rs2716610: C>T polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: C>T might affect a glucose control in patients with MS.

Keywords: metabolic syndrome, LPIN1 gene, markers, gene variations.

How to Cite:

Bego, T., Dujić, T., Mlinar, B., Semiz, S., Malenica, M., Prnjavorac, B., Ostanek, B., Marc, J., Čaušević-Ramoševac, A. & Čaušević, A., (2015) “Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina”, Medicinski glasnik 13(2). doi: https://doi.org/10.17392/797-15