Original article

Association of HLA-B27 antigen with clinical and laboratory parameters in patients with juvenile idiopathic arthritis

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Abstract

Aim: To analyse the association of human leukocyte antigen B27 with clinical and laboratory parameters in patients with juvenile idiopathic arthritis (JIA) at the disease onset.

Methods: A retrospective review of medical records of 25 HLAB27 positive and 25 HLA-B27 negative JIA patients was performed. The diagnosis of JIA was based on the 1997-2001 International League Against Rheumatism (ILAR) criteria. Collected data: age, sex, HLA- B27 antigen presence, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid-factor (RF), antinuclear antibody (ANA), fever, rash, uveitis, enthesitis, inflamed joints and subtype of JIA.

Results: HLA- B27 positive study group had more boys (p=0.01), higher erythrocyte sedimentation rate (p=0.038), higher presence of fever (p= 0.025) and enthesitis (p=0.024). Any significant difference in age of the disease onset, CRP, ANA, RF, rash, uveitis, inflamed joint and dactylitis was not noticed. The most common subtype of JIA in the HLA-B27 positive patients was ERA (60%).

Conclusion: This study showed that the presence of HLA- B27 antigen plays a significant role in determining the presenting clinical and laboratory characteristics in JIA patients.

Keywords: arthritis, children, human leukocyte antigen

How to Cite:

Čengić, A., Selmanović, V., Hasanbegović, S., Begić, N., Karčić, E. & Fejzić, E., (2022) “Association of HLA-B27 antigen with clinical and laboratory parameters in patients with juvenile idiopathic arthritis”, Medicinski glasnik 20(1), 580-62. doi: https://doi.org/10.17392/1556-22