Original article

Correlation of signal to noise ratio (SNR) value on distortion product otoacoustic emission (DPOAE) and expression of nuclear factor erythroid 2-related factor 2 (NRF2) in cochlear organ of Corti in rat exposed to noise

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Abstract

Aim: To investigate the changes in the value of the signal to noise ratio (SNR) and to assess changes in the expression of nuclear factor erythroid 2-related factor 2 (NRF2) in the organ of Corti of rat exposed to noise.

Methods: This study used a randomized post test only control group laboratory experimental design with 27 male Wistar strain Rattus norvegicus. The study group was divided into 3 groups (n = 9): group I (control), group 2 (2 hours of 100 dB noise exposure) and group 3 (2 hours of 110 dB noise exposure).

Results: There was no significant difference in the SNR in the group 1 on day 0, 2 and 4 (p>0.05). However, there was a significant difference in the SNR in the group 2 and the group 3 on day 0, 2 and 4 (p<0.05). There was a significant difference in the mean levels of NRF2 expression in the cochlear organ of Rattus norvegicus in all groups (p<0.05). There was no correlation between the SNR and the NRF2 expression in group 2 (p> 0.05), but there was a correlation between the SNR and the NRF2 expression in the group 3 (p<0.05).

Conclusion: There was found a correlation between the SNR value on distortion product otoacoustic emission (DPOAE) examination and NRF2 expression in the cochlear organ of Corti of Rattus norvegicus exposed to 110 dB noise.

Keywords: animal, experimental, immunohistochemistry