The serum triglyceride to high-density lipoprotein (HDL) ratio in patients with acute coronary syndrome with and without renal dysfunction
- Alen Džubur
(Clinic for Heart Disease, Blood Vessels and Rheumatism, University Clinical Centre Sarajevo, Sarajevo, Bosnia and Herzegovina)
- Malik Ejubović (Cantonal Hospital Zenica, Zenica, Department of Internal Diseases, Bosnia and Herzegovina)
- Fajkić Almir (School of Medicine, University of Sarajevo, Sarajevo, Department of Pathophysiology, Bosnia and Herzegovina)
- Amela Dervišević (School of Medicine, University of Sarajevo, Sarajevo, Department of Human Physiology, Bosnia and Herzegovina)
- Azra Durak Nalbantić (Clinic for Heart Disease, Blood Vessels and Rheumatism, University Clinical Centre Sarajevo, Sarajevo, Bosnia and Herzegovina)
- Ajla Avdić Agić (Marien Hospital Witten, Witten, Germany)
- Amela Džubur (School of Medicine, University of Sarajevo, Sarajevo, Department of Public Health, Bosnia and Herzegovina)
- Mevludin Mekić (Clinic for Heart Disease, Blood Vessels and Rheumatism, University Clinical Centre Sarajevo, Sarajevo, Bosnia and Herzegovina)
Abstract
Aim: To assess triglyceride-to high-density lipoprotein cholesterol (TG/HDL)-C ratio in patients with acute coronary syndrome (ACS) and to verify its association with renal dysfunction.
Methods: A cross sectional study included 85 ACS patients divided in two groups with (ACS-RD) and without (ACS-nRD) presence of renal dysfunction, and 35 healthy subjects. Blood pressure, blood glucose, C-reactive protein, urea, creatinine, eGFR and serum lipids levels (total cholesterol, triglycerides, LDL-C, HDL-C) was measured in all participants. Based on the values of the measured lipid fractions TG/HDLc ratio was calculated.
Results: Patients in ACS group had significantly lower HDL-C level (p<0.0005) but significantly higher TG level (p=0.046) and TG/HDL-C ratio (p<0.0005) than controls. There was a significant increase (p<0.0005) in TG/HDL-C ratio in ACS-RD group compared to ACS-nRD group. The ACS-RD group had significantly higher level of TG (p=0.001), serum urea (p=0.02) and creatinine (p<0.0005) compared to the ACS-nRD group. With a cutoff level of 1.135 TG/HDL-C ratio had a sensitivity of 77.6% and a specificity of 62.9% in distinguishing between ACS patients and healthy subjects. With cutoff value of 1.905 TG/HDL-C ratio had a sensitivity of 75.9% and a specificity of 78.6% in distinguishing between ACS patients with and without renal dysfunction.
Conclusion: This study confirms the reliability of the TG/HDL-C ratio as a simple, low cost and useful marker in distinguishing between patients with ACS and healthy subjects and ACS patients with and without renal dysfunction.
Keywords: eGFR, NSTEMI, STEMI, TG/HDL-C ratio
How to Cite:
Džubur, A., Ejubović, M., Almir, F., Dervišević, A., Durak Nalbantić, A., Avdić Agić, A., Džubur, A. & Mekić, M., (2018) “The serum triglyceride to high-density lipoprotein (HDL) ratio in patients with acute coronary syndrome with and without renal dysfunction”, Medicinski glasnik 16(1), 28-34. doi: https://doi.org/10.17392/990-19
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