Original article

A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction

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Abstract

Aim: To determine the relationship of homocysteine (HCY), uric acid (UA) and C-reactive protein (CRP) in serum of patients with acute myocardial infarction (AMI) prior to application of percutaneous coronary intervention (PCI) and their level of correlation in serum of patients with normal and elevated CRP (predictor of worse cardiovascular outcomes).

Methods: The study involved 85 patients with diagnosed AMI. Before the PCI, venous blood samples were taken into the vacuum test tubes. The analysis of HCY, UA, inflammatory markers CRP and neutrophil to lymphocyte ratio (NLR) as well as lipoprotein status were performed on a different type of analysers and according to accepted protocols of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC).

Results: Elevated level of both HCY and UA in AMI patients as well as a positive correlation between HCY and UA level was observed. Classification of patients on the basis of mean UA concentration showed significant difference at the level of HCY concentration (p=0.022).

Conclusion: Since HCY and UA participate in the atherosclerotic process and their metabolism, as well as the effects on the cardiovascular system show significant overlaps, their serum level should be analysed synchronously with the level of CRP and NLR (indicators of significant inflammatory process in vessels). Considering a potential link between all parameters observed, further research involving a greater number of patients and including the post treatment effects should be conducted.

Keywords: ST elevation myocardial infarction, inflammation, atherosclerosis, oxidative stress

How to Cite:

Marković Boras, M., Čaušević, A., Brizić, I., Mikulić, I., Vasilj, M. & Jelić-Knezović, N., (2018) “A relation of serum homocysteine, uric acid and C-reactive protein level in patients with acute myocardial infarction”, Medicinski glasnik 15(2), 101-108. doi: https://doi.org/10.17392/956-18