Influence of C-reactive protein on the occurrence and assessing of albuminuria severity in diabetics
- Lamija Pojskić
(Cantonal Hospital Zenica, Zenica, Department of Internal Diseases, Bosnia and Herzegovina)
- Sabaheta Hasić (University of Sarajevo, Sarajevo, Faculty of Medicine, Department of Medical Biochemistry, Bosnia and Herzegovina)
- Ema Tahto (Clinic for Cardiovascular Surgery, University Clinical Center Tuzla, Tuzla, Bosnia and Herzegovina)
- Vildana Arnautović-Torlak (Cantonal Hospital Zenica, Zenica, Department of Internal Diseases, Bosnia and Herzegovina)
- Belma Pojskić (Cantonal Hospital Zenica, Zenica, Department of Internal Diseases, Bosnia and Herzegovina)
- Branka Bedenić (School of Medicine, University of Zagreb, Clinical Depart ment of Clinical and Molecular Microbiology, University Hospital Center Zagreb Zagreb, Croatia)
Abstract
Aim: To asses relation of serum high sensitive C-reactive protein (hsCRP) level with albumin concentration in daily urine in patients with diabetes mellitus type 2 (T2DM).
Methods: The prospective study included 69 patients with T2DM, both sexes (24 males, 45 females), aged 30-82 years. They were divided into two groups: patients with T2DM and normoalbuminuria (T2DM-NA; n=40) and patients with T2DM and microalbuminuria (T2DM-MA; n=29). Patients were hospitalized at the Department of Internal Medicine, Cantonal Hospital Zenica, in the period January-April 2014. Immunonephelometry measurement of hsCRP was performed on the Nephelometer Analyzer BN II (Siemens, Germany).
Results: Frequency of patients in T2DM-NA and T2DM-MA groups was not significantly different in relation to sex and age. There was significant difference in relation to duration of diabetes ( p=0.001). Average glucose and HbA1c levels were significantly higher in T2DM-NA group comparing to T2DM-MA group (p=0.008 and p=0.047, respectively). Serum creatinine (p=0.011), urea (p=0.009) and hsCRP (p=0.005) were significantly higher in T2DM-MA group compared to T2DM-NA group. Urinary albumin showed significantly positive correlation with the hsCRP (rho=0.286; p=0.017), urea (rho=0.503) and creatinine (rho=0.438) (p<0.0005). A one unit (mg/L) increase in hsCRP concentration was associated with 11.5% increase of odds of microalbuminuria OR=1.115; 95% CI 1.014-1.225; p=0.025).
Conclusion: Significantly higher values of serum hsCRP in patients with type 2 diabetes mellitus and microalbuminuria in comparison to those with normoalbuminuria as well as the correlation of values of inflammatory marker with urinary albumin implicate a low grade inflammation in the progression of diabetic nephropathy.
Keywords: diabetic nephropathy, endothelium, inflammation
How to Cite:
Pojskić, L., Hasić, S., Tahto, E., Arnautović-Torlak, V., Pojskić, B. & Bedenić, B., (2017) “Influence of C-reactive protein on the occurrence and assessing of albuminuria severity in diabetics”, Medicinski glasnik 15(1). doi: https://doi.org/10.17392/919-18
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