,
Department of Orthopaedics and Traumatology, Vito Fazzi Hospital, Lecce, Italy
Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Ortopedico Galeazzi, Milan, Italy
Department of Orthopaedics and Traumatology, AORN SAN PIO “Gaetano Rummo Hospital”, Benevento, Italy
Malattie Infettive Osteo-Articolari MIOS, S. Maria di Misericordia Hospital, Savona, Italy
Department of Orthopaedics and Traumatology, Poliambulanza Foundation Hospital, Brescia, Italy
Russian Ilizarov Scientific Centre “Reconstructive Traumatology and Orthopaedics”, Kurgan, Russia
Department of Medicine and Health Sciences 'Vincenzo Tiberio' , University of Molise, Campobasso, Italy
Department of Orthopaedics and Traumatology, AORN SAN PIO “Gaetano Rummo Hospital”, Benevento, Italy
Division of Orthopaedics and Trauma Surgery, University of Perugia, “S. Maria della Misericordia” Hospital, Perugia, Italy
Department of Orthopaedics and Traumatology, Vito Fazzi Hospital, Lecce, Italy
School of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina
Orthopaedics and Traumatology Unit, Villa del Sole Caserta, Caserta, Caserta, Italy
Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Ortopedico Galeazzi, Milan, Italy
Department of Biomedical Sciences for Health, University of Milan, Milan, Italy
Department of Orthopaedics and Traumatology, AORN SAN PIO “Gaetano Rummo Hospital”, Benevento, Italy
Aim
The septic non-union is a common compliance in bone healing due to bone infection. Bone resection, associated with Ilizarov osteo-distraction technique, is commonly used in these cases. The aim of this study was to analyse clinical and radiological results of teriparatide in combination with the Ilizarov technique and to compare this treatment with the standard treatment.
Methods
Forty adult patients underwent surgery because of type C of the Association for the Study and Application of Methods
of Ilizarov (ASAMI) classification non-union were enrolled. The patients were divided in two groups: those treated with Ilizarov technique (Norm group) and those treated with Ilizarov technique combined with teriparatide injection (Teri group). Surgical duration, complication rate, bone healing status, clinical and functional outcomes were assessed according to the A.S.A.M.I. classification in the mean follow-up of 12 months. The subjective quality of life was assessed by the Short Form Survey (SF)-12.
Results
Teri group showed less time wearing Ilizarov's frame (p<0.05) than the Norm group and a statistical significance in the inter-rater reliability Cohen’s k (p>0.05) respect to Norm according the score between the bone healing and clinical outcome results. There was no statistically significant difference between the two groups in other parameters that were assessed.
Conclusion
A benefit of teriparatide was found as adjuvant in the treatment of septic non-union.
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