,
Faculty of Pharmacy, University of Tuzla , Tuzla , Bosnia and Herzegovina
General Hospital, Tešanj , Tešanj , Bosnia and Herzegovina
Department of Pathophysiology, Faculty of Pharmacy , Sarajevo , Bosnia and Herzegovina
Department of Clinical Biochemistry, Faculty of Pharmacy , Sarajevo , Bosnia and Herzegovina
Department of Biochemistry, University of Tuzla , Tuzla , Bosnia and Herzegovina
Department of Biochemistry, Faculty of Pharmacy, University of Tuzla , Tuzla , Bosnia and Herzegovina
Department of Cardiology, General Hospital "Prim.dr. Abdulah Nakaš" , Sarajevo , Bosnia and Herzegovina
Department of Pharmacology, School of Medicine, Sarajevo School of Science and Technology , Sarajevo , Bosnia and Herzegovina
Department of Clinical Biochemistry, Faculty of Pharmacy , Sarajevo , Bosnia and Herzegovina
General Hospital, Tešanj , Tešanj , Bosnia and Herzegovina
General Hospital, Tešanj , Tešanj , Bosnia and Herzegovina
Aim
To investigate interleukin 6 (IL-6) values depending on duration of diabetes mellitus (DM) and evaluate possible correlation
with diabetic polyneuropathy.
Methods
The research study included 90 patients with DM divided into three groups (30 patients each) according to the duration
of DM: group A – patients who had DM for less than 10 years, group B - duration of DM was 10 to 20 years, and group C - patients with DM over 20 years. Control group (K) included 30 healthy participants.
Results
IL-6 was significantly higher in the healthy control group, 180.318 pg/mL±94.18, than in group A, 47.23pg/ml±34.8, group B, 43.31pg/ml±33.17, and group C, 70.39 pg/ml±59.26 (p=0.0001). All groups had significantly different values of IL-6 between each other (p=0.0001). Level of IL-6 was in correlation with diabetic polyneuropathy in the group A (the youngest participants) (p=0.0001). In other groups there was no significant correlation between IL-6 and diabetic polyneuropathy.
Conclusion
The level of IL-6 was in correlation with neuropathy among younger patients. A higher level of IL-6 in the control group
than in diabetic groups is a sign of stronger inflammatory response among younger and healthy people than in patients with DM.
This work is licensed under a Attribution-NonCommercial-NoDerivatives 4.0 International 
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