,
Department of General Surgery, University General Hospital , Patras , Greece
Department of Anaesthesiology, University General Hospital , Patras , Greece
Department of Internal Medicine, University General Hospital , Patras , Greece
Department of General Surgery, University General Hospital , Patras , Greece
Department of General Surgery, University General Hospital , Patras , Greece
Department of General Surgery, University General Hospital , Patras , Greece
Aim
To investigate analgesic effect of three different regimens of combination of analgesics administered to patients undergoing laparoscopic cholecystectomy.
Methods
Patients undergoing laparoscopic cholecystectomy were randomly allocated to one of three groups on admission, depending of a prescribed post-operative analgesic regimen. Patients allocated to the group A received a combination of intravenous (IV) acetaminophen and intramuscular (IM) pethidine, patients in the group B received a combination of IV acetaminophen and IV parecoxib, and the patients of the group C received IV acetaminophen monotherapy. Analgesic therapy was administered at regular intervals. Pain was evaluated utilizing the numeric rating scale (NRS) at 5 time points: the first assessment was done at 45 minutes, the second, third, fourth and fifth at 2, 6, 12, and 24 hours
post-administration, respectively. Postoperative pain intensity was measured by NRS within the groups and between the groups at each time they analysed using one-way repeat measured ANOVA and Post Hoc Test-Bonferroni Correlation.
Results
A total of 316 patients were enrolled. The analgesic regimens of groups A and B (combination regimens consisting of IV acetaminophen and intramuscular pethidine and IV acetaminophen and IV parecoxib, respectively) were found to be of equivalent efficacy (p=1.000). In contrast, patients in group C (acetaminophen monotherapy) had higher NRS scores, compared to both patients in groups A (p<0.01) and B (p<0.01).
Conclusion
This study confirms the notion of a significant opioid-sparing effect of parecoxib in postoperative pain management
after laparoscopic cholecystectomy.
This work is licensed under a Attribution-NonCommercial-NoDerivatives 4.0 International 
7
Kalthoum AlAwadhi, Fahad A Allafi, Bader A Almukaimi, Ahmad Alkandari, Saoud A Alenezi, Awatef Alenezi, Shaikhah Alenezi, Sara Alenezi, Nasser Alenezi, Abdullah Fahiman, Abdulwahab Alsalem, Muteb Alotaibi
(2024)
Analgesic Efficacy of EMLA Cream Among Patients Undergoing Hemorrhoidectomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Cureus, ()
10.7759/cureus.66423
Srikanth Marthandam, Mallikarjun Gunjiganvi, Surendra Jasthi, Ramya Atluri, Y Satish Reddy, Venkatesh Martandam
(2024)
A Comparative Study of Laparoscopic Versus Robotic Cholecystectomies Based on the Parkland Grading Scale
Cureus, ()
10.7759/cureus.68523
Hoda Mohamed Bayoumi, Doaa Hamed Abdelaziz, Nouran Omar El Said, Sherif Boraii, Ehab Rasmy Bendas
(2024)
Postoperative pain management following laparoscopic cholecystectomy-non-opioid approaches: a review
Future Journal of Pharmaceutical Sciences, 10(1)
10.1186/s43094-024-00697-z
Chairat Supsamutchai, Ratanakiat Pongratanakul, Jakrapan Jirasiritham, Puvee Punmeechao, Napaphat Poprom, Jarinya Wilasrusmee, Theejutha Meakleartmongkol, Settanan Plangsiri, Chumpon Wilasrusmee
(2025)
Differences in the rates of seroma complications between hernial sac transection and reduction after laparoscopic inguinal hernia repair: systematic review and meta-analysis
Scientific Reports, 15(1)
10.1038/s41598-025-94683-x
Varsha Gupta, Abhinav Abhinav, Srineil Vuthaluru, Shivam Kalra, Akshita Bhalla, Abhinav K Rao, Manjeet K Goyal, Ashita R Vuthaluru
(2024)
The Multifaceted Impact of Gallstones: Understanding Complications and Management Strategies
Cureus, ()
10.7759/cureus.62500
Akhil Arun, L Triveni, V Subhiksha, Beulah Milton, Gomathy E
(2025)
A Comparative Cost-Effectiveness Analysis of Intravenous Infusion Acetaminophen and Intramuscular Diclofenac for Post-Hysterectomy Pain Management: The AIDA Study
Research Journal of Pharmacy and Technology, ()
10.52711/0974-360X.2025.00149
Shangmin Chen, Mengzhen Min, Lin Du, Yongshan Gao, Lei Xie, Junjie Gao, Liping Li, Zhigang Zhong
(2025)
Trajectories of obesity indices and their association with pain in community-dwelling older adults: Findings from the English longitudinal study of ageing
Archives of Gerontology and Geriatrics, 129()
10.1016/j.archger.2024.105690The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.