Association between CD133 expression and clinicopathological profile in colorectal cancer
Aim To investigate CD133 expression and its relationship to clinicopathological profile in colorectal cancer (CRC) patients.Methods This cross-sectional study was performed at the Internal Medicine Department, School of Medicine, Adam Malik GeneralHospital. The colorectal cancer tissue was taken from surgical resection and colonoscopy biopsy from C...
By Imelda Rey, Agung Putra, Dharma Lindarto, Fauzi Yusuf
Cardiac biomarkers and left ventricular systolic function in acute myocardial infarction with ST- segment elevation in diabetes mellitus type 2 patients
Aim To determine a status of systolic function in patients with diabetes mellitus (DM) type 2 with ST-segment elevation acute myocardial infarction (STEMI), to determine values of cardiac biomarkers in patients with DM type 2 with STEMI and correlate the parameters with ejection fraction of left ventricle (EFLV). Methods A total of 80 patients were...
By Mirela Halilčević, Edin Begić, Alen Džubur, Nirvana Šabanović-Bajramović, Mevludin Mekić, Malik Ejubović, Amela Džubur, Ena Štimjanin
Lifestyle risk factors and comorbidities of cancer patients in a country with limited resources
Aim To investigate quality of life and exposure to lifestyle risk factors of cancer patients in Bosnia and Herzegovina and a correlation of cancer type with lifestyle risk factors. Methods This was a cross-sectional study conducted on 200 cancer patients from the Clinical Centre of the University of Sarajevo. The respondents completed an anonymous ...
By Nejra Mlačo, Armin Šljivo, Ahmed Mulać, Amina Kurtović-Kozarić, Anes Pašić, Semir Bešlija, Šejla Cerić, Timur Cerić
Association of endothelial nitric oxide synthase gene (G894T) polymorphism and hypertension in diabetic Bataknese patients
Aim To assess endothelial nitric oxide synthase (eNOS) gene (G894T) polymorphism and nitric oxide (NO) level in hypertensive diabetic Bataknese patients.Methods A hospital-based, case control study (hypertensive and normotensive diabetic patient) was conducted. Genotyping ofeNOS gene (G894T) was done using polymerase chain reactionrestriction fragm...
By Jelita Siregar, Ratna Akbari Ganie, Dharma Lindarto, Erna Mutiara, Delfitri Munir
Poguntano effect on cell viability in cholesteatoma keratinocyte of chronic suppurative otitis media
Aim Chronic Suppurative Otitis Media (CSOM) with or without cholesteatoma is a global major problem and it is becoming a burden especially in developing countries. Studies have found that ethanol extracts of Puguntano leaves obtained by the percolation and socletation methods have phytochemical contents that provide anti-inflammatory effect. The ai...
By Harry A. Asroel, Aznan Lelo, Delfitri Munir, Jenny Bashiruddin, Restu Syamsul Hadi
Epidemiology of neonatal sepsis caused by multidrug resistant pathogens in a neonatal intensive care unit level 3
Aim Steady progress in intensive treatment worldwide has increased the survival of immature neonates, but with multiple invasive procedures, which have increased the risk of infection, thus the bacterial resistance to antibiotics. The aim of this study was to analyse the epidemiology of multidrug resistance pathogens as causative agents of neonatal...
By Devleta Hadžić, Fahrija Skokić, Selmira Brkić, Amina Saračević, Delila Softić, Dženana Softić
An ethanol extract of Senduduk fruit (Melastoma malabathricum L) inhibits the expression of vascular endothelial growth factor and tumour necrosis factor alpha in HeLa cells
Aim Senduduk fruit (Melastoma malabathricum L) is native to Indomalaya and is believed to possess anticancer activity. This study investigated antiangiogenic and anti-inflammation effects of an ethanolic extract of Senduduk fruit (EESF) on HeLa cells. Methods Cytotoxicity was assayed in HeLa cell cultures exposed to a concentration series of 500-7....
By Deri Edianto, Aznan Lelo, Syafruddin Ilyas, Marline Nainggolan
The effect of roselle flower petals extract (Hibiscus sabdariffa Linn.) on reducing inflammation in dextran sodium sulfateinduced colitis
Aim To determine the effect of roselle (Hibiscus sabdariffa) petals in dextran sodium sulfate (DSS)-induced colitis model by measuring pro-inflammatory cytokines expressions (IL-6, and TNF-α), anti-inflammatory cytokine expression (IL-10) and histological colitis inflammation score (HCIS). Methods This study was conducted in two phases. For t...
By Masrul Lubis, Gontar Alamsyah Siregar, Hakim Bangun, Syafruddin Ilyas
Preterm and term birth in twin pregnancies during a seven-year period: a call for obstetricians to declare about amnionicity and chorionicity
Aim To compare maternal, foetal and neonatal characteristics, and perinatal outcome of preterm and term deliveries in twins pregnancies in order to improve perinatal care in Bosnia and Herzegovina. Methods This retrospective cohort study included pregnant women with twin pregnancy who delivered during the period between 1 January 2012 and 31 Decemb...
By Anis Cerovac, Gordana Grgić, Dženana Softić, Dženita Ljuca, Sergije Marković, Amer Mandžić
Endothelin-1 level as a predictor of hepatopulmonary syndrome in liver cirrhosis
Aim To determine the role of endothelin (ET)-1 in predicting hepatopulmonary syndrome (HPS) in patients with liver cirrhosis. Methods A cross sectional study involving 80 liver cirrhosis patients aged 18 years or older was conducted in Adam Malik General Hospital Medan, Indonesia between July 2017 and June 2018. HPS diagnosis was confirmed from the...
By Dr Darmadi, Riska Habriel Ruslie