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Review paper
Received: 19.06.2019. >> Accepted: 04.10.2019. >> Published: 22.09.2019. Biochemistry
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https://doi.org/10.17392/1053-20

Bone marrow adiposity is inversely associated with bone mineral density in postmenopausal females

By
Lejla Milišić Orcid logo ,
Lejla Milišić
Contact Lejla Milišić

Clinic of Radiology, Clinical Centre of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Sandra Vegar-Zubović ,
Sandra Vegar-Zubović

Clinic of Radiology, Clinical Centre of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Amina Valjevac ,
Amina Valjevac

Department of Human Physiology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Suada Hasanović-Vučković
Suada Hasanović-Vučković

Clinic of Radiology, Clinical Centre of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina

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Abstract

Aim
 To evaluate vertebral bone marrow adiposity (BMA) using magnetic resonance spectroscopy (MRS) in postmenopausal women and to determine an association of bone density with bone marrow fat content.
Methods
 This cross-sectional study included 120 postmenopausal women referred for osteoporosis screening. All women underwent assessment of bone mineral density by dual X-ray absorptiometry (DXA), who were divided based on T scores into osteoporosis (OST; n=60) and control group (CG; n=60). MRS was used to measure fat fraction (FF), lipid/water ratio (LWR) and fat content (FC) at vertebral spine (L1-L4).
Results
Mean age, menopause or reproductive period duration was not significantly different between women in OST and control group. Median LWR in OST group was significantly higher compared to CG, 31.5 (22.9-38.8) vs. 28.7 (13.7-37.3) (p=0.039). Median FC was significantly higher in OST compared to the control group, 47.0 (46.3-78.8) and 46.4 (44.3-48.6), respectively (p=0.011). FC was significantly negatively associated with BMD at lumbar spine (Rho=-0.042; p<0.001) and with BMD at hip (Rho=-0.64; p<0.001). In logistic regression model, FC remained independently associated with osteoporosis after controlling for confounders (age, menopause duration, reproductive period duration and body mass index) (OR=1.3; 95% CI 1.1-1.6).
Conclusion
 Bone marrow adiposity is an independent predictor of low bone mass in postmenopausal women suggesting its role as a therapeutic target in postmenopausal osteoporosis management.

Keywords:

adiposity,
magnetic resonance spectroscopy,
osteoporosis

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