Aim Allergic rhinitis (AR) is an IgE-mediated inflammation of the nose. Regulatory T cells (Tregs), plasma cells and inflammatory cytokines have shown to play a critical role in allergic airway inflammation. The aim of the study was to investigate the role of mesenchymal stem cells (MSCs) in generating Treg cells and plasma cells associated with re...

By Delfitri Munir, Iqbal Pahlevi Nasution, Lia Restimulia, Agung Putra, Nur Dina Amalina

Aim Allergic rhinitis (AR) is a heterogeneous condition that has been associated with inflammatory responses and is characterized by clinical typical symptoms of nasal itching, sneezing, watery discharge and congestion. Mesenchymal stem cells (MSCs) are multipotent stem cells that have the immunoregulatory ability by secreting various cytokines whi...

By Lia Restimulia, Syafruddin Ilyas, Delfitri Munir, Agung Putra, Teti Madiadipoera, Farhat Farhat, Rosita Juwita Sembiring, Muhammad Ichwan, Nur Dina Amalina

Aim Mesenchymal stem cells (MSCs) have potent immunosuppressive properties to control systemic lupus erythematosus (SLE) disease by inhibiting indoleamine 2,3-dioxygenase (IDO), and increasing regulatory T cells (Treg) to control innate and adaptive immune cells. However, the interaction and mechanism regarding IDO and B cells in the co-culture of ...

By Dewi Masyithah Darlan, Delfitri Munir, Agung Putra, Iffan Alif, Nur Dina Amalina, Nelva Karmila Jusuf, Imam Budi Putra

Aim Acute rhinosinusitis (AR) is of viral aetiology and only 0.5-2% develop into acute bacterial rhinosinusitis. Herbal therapy is a promising alternative in acute bacterial rhinosinusitis treatment. The aim of this study was to evaluate the effect of ethanol extract of Poguntano leaves (EEPL) to procalcitonin level and the amount of bacteria in ac...

By Andrina Yunita Murni Rambe, Delfitri Munir, Rosita Juwita Sembiring, Syafruddin Ilyas

Aim To assess endothelial nitric oxide synthase (eNOS) gene (G894T) polymorphism and nitric oxide (NO) level in hypertensive diabetic Bataknese patients.Methods A hospital-based, case control study (hypertensive and normotensive diabetic patient) was conducted. Genotyping ofeNOS gene (G894T) was done using polymerase chain reactionrestriction fragm...

By Jelita Siregar, Ratna Akbari Ganie, Dharma Lindarto, Erna Mutiara, Delfitri Munir

Aim Chronic Suppurative Otitis Media (CSOM) with or without cholesteatoma is a global major problem and it is becoming a burden especially in developing countries. Studies have found that ethanol extracts of Puguntano leaves obtained by the percolation and socletation methods have phytochemical contents that provide anti-inflammatory effect. The ai...

By Harry A. Asroel, Aznan Lelo, Delfitri Munir, Jenny Bashiruddin, Restu Syamsul Hadi

Aim To analyse the ability of mesenchymal stem cells (MSCs) to regulate interleukin 6 (IL-6) and transforming growth factor (TGF-β) expression in vitro under co-culture conditions in human systemic lupus erythematosus (SLE). MethodThis study used a post-test group design that used peripheral blood mononuclear cells (PBMCs) from SLE patients at...

By Dewi Masyithah Darlan, Delfitri Munir, Nelva Karmila Jusuf, Agung Putra, Riyadh Ikhsan, Iffan Alif