Aim To determine the effect of secretome hypoxia mesenchymal stem cells (SH-MSCs) on the relative gene expression of hypoxia inducible factor-1a (HIF-1a) and basic fibroblast growth factor (bFGF) in accelerating histomorphometric repair of tendon to bone interface healing in rats acute rotator cuff tear (RCT) model.Methods This is experimental rese...

By Meiky Fredianto, Herry Herman, Yoyos Dias Ismiarto, Agung Putra, Iffan Alif, Nur Dina Amalina, Muhammad Ariq Nazar

Aim To determine the effect of Clitorea ternatea flower extract (CTFE) in the gel dosage form on the expression of GPx and platelet-derived growth factor (PDGF) in ultraviolet (UV) - B irradiation-induced collagen loss rat model.Methods This is experimental research with post-test control group design. Twenty healthy male Wistar rats were divided i...

By Rizka Sofyanti Putri, Agung Putra, Dr Chodidjah, Dewi Masyitah Darlan, Setyo Trisnadi, Siti Thomas, Nur Dina Amalina, Rizky Candra Irawan

Aim Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by the chronic inflammation of the pancreatic islets of Langerhans. Hyperglycaemia leads to suppressed antioxidant enzyme and increased inflammation in the pancreatic cell, resulting in pancreatic cell death. Hypoxic secretome mesenchymal stem cells (HS-MSCs) are soluble mol...

By Ayuningtyas Utami, Agung Putra, Joko Wahyu Wibowo, Amalina Nur Dina, Risky Chandra Satria Irawan

Aim Allergic rhinitis (AR) is an IgE-mediated inflammation of the nose. Regulatory T cells (Tregs), plasma cells and inflammatory cytokines have shown to play a critical role in allergic airway inflammation. The aim of the study was to investigate the role of mesenchymal stem cells (MSCs) in generating Treg cells and plasma cells associated with re...

By Delfitri Munir, Iqbal Pahlevi Nasution, Lia Restimulia, Agung Putra, Nur Dina Amalina

Aim To determine the effect of red algae extract on the gene expression of catalase and caspase-3 in testicules of rats induced by boric acid (BA).Methods This is experimental research with post-test control group design. Twenty four healthy male Wistar rats were divided intofour treatment groups: a healthy group, negative control group, two treatm...

By Ayu Renda Sari, Joko Wahyu Wibowo, Sri Priyantini, Agung Putra, Nur Dina Amalina

Aim Triple negative breast cancer cells (TNBC) are the population of breast cancer cells that are responsible for cancer recurrence and apoptosis resistance. Unfortunately, current therapies have limited efficacy to TNBC population due to apoptosis resistance and chemoresistance. Tumour suppressor p53 and survivin are primary targets for TNBC thera...

By Deryne Anggia Paramita, Dedy Hermansyah, Desiree Anggia Paramita, Nur Dina Amalina

Aim Allergic rhinitis (AR) is a heterogeneous condition that has been associated with inflammatory responses and is characterized by clinical typical symptoms of nasal itching, sneezing, watery discharge and congestion. Mesenchymal stem cells (MSCs) are multipotent stem cells that have the immunoregulatory ability by secreting various cytokines whi...

By Lia Restimulia, Syafruddin Ilyas, Delfitri Munir, Agung Putra, Teti Madiadipoera, Farhat Farhat, Rosita Juwita Sembiring, Muhammad Ichwan, Nur Dina Amalina

Aim Mesenchymal stem cells (MSCs) have potent immunosuppressive properties to control systemic lupus erythematosus (SLE) disease by inhibiting indoleamine 2,3-dioxygenase (IDO), and increasing regulatory T cells (Treg) to control innate and adaptive immune cells. However, the interaction and mechanism regarding IDO and B cells in the co-culture of ...

By Dewi Masyithah Darlan, Delfitri Munir, Agung Putra, Iffan Alif, Nur Dina Amalina, Nelva Karmila Jusuf, Imam Budi Putra