Aim to investigate the potential of SG followed by injection of MSCs in type 2 diabetic rats with obesity in improving IR. Methods This study used a pre and post-control group design with 24 rats divided into three groups: Control (C), SG, and SG + MSCs (SG+M). On day 10, the level of vascular endothelial growth factor (VEGF), tumor necrosis facto...

By Vito Mahendra Eka Saputra, Agung Putra,, Titiek Sumarawati, Sugeng Ibrahim, Meidona Nurul Mila, Arini Dewi Antari, Fadhli Rizal Makarim, Iffan Alif, Ghaitsa Hasnadia Anggoro, Namira Latifah Sa'adah, Rania Maharani, Windy Listiana

Functional gastrointestinal disorders in childhood (FGIDs) constitute a significant time-consuming clinical problem for healthcare practitioners, and they carry an important psychosocial burden for patients and their families. The aim of this study was to characterize etiology, clinical features, and interventions in a paediatric cohort of patients...

By Amela Selimović, Nina Mekić, Selma Terzić, Almira Ćosićkić, Evlijana Zulić, Majda Mehmedović

Aim Significant risk factors for femoral nail cutout are well-documented, primarily in the context of single-screw proximal nails.However, it remains uncertain whether those same risk factors are applicable when considering different implant devices. The aim of this retrospective cohort study was to compare cutout risk factors between single- versu...

By Michele Coviello, Antonella Abate, Giovanni Vicenti, Francesco Ippolito, Vittorio Nappi, Andrea Michele Abbaticchio, Elio Caiaffa, Giulia Colasuonno, Vincenzo Caiaffa, Giuseppe Solarino

Aim To investigate whether the use of ion resonance and bromelain-vitamin C or bromelain-vitamin C is the best to prevent ankle complications in post operative bimalleolar surgery.Methods A total of 61 patients treated with bimalleolar surgery were enrolled. The patients were divided into three groups: thefirst group (n=22) treated only with the su...

By Luigi Meccariello, Anna Iolanda Bello, Giovanni Bove, Nicola Gagliardo, D’Anna Raffaele, Luigi Matera

Aim Lung adenocarcinoma (ADC) is a leading subtype of lung cancer, histologically defined with five different architecturalgrowth patterns: lepidic, acinar, papillary, solid and micropapillary. The aim of this study was to explore the prevalence of epidermal growth factor receptor (EGFR) mutation and a relationship between the specific histological...

By Dalma Udovičić-Gagula, Nejra Džananović, Mirsad Dorić

Aim This study provides a comprehensive review of the current literature on the use of ChatGPT, a generative Artificial Intelligence (AI) tool, in neurosurgery. The study examines potential benefits and limitations of ChatGPT in neurosurgical practice and education.Methods The study involved a systematic review of the current literature on the use ...

By Hakija Bečulić, Emir Begagić, Rasim Skomorac, Anes Mašović, Edin Selimović, Mirza Pojskić

Aim To evaluate patient satisfaction with primary healthcare services and determine effectiveness indicators within Kazakhstan's compulsory health insurance system.Methods An analytical observational study with cross-examination was conducted in Kazakhstan's primary healthcare (PHC) organizations. Patient satisfaction was assessed through a 35-item...

By Makhabbat Shurenova, Kuralbay Kurakbayev, Tleukhan Abildaev, Aigul Tazhiyeva

Aim To investigate the prevalence of familial hypercholesterolemia in patients with acute coronary syndrome (ACS).Methods The study included fifteen patients with first or repeated ACS and treated/nontreated dyslipidaemia admitted to the Department of Cardiovascular Diseases of Clinical Hospital Centre Osijek between 1 January 2020 and 1 January 20...

By Željka Dragila, Matea Lozert, Silvija Canecki-Varžić, Kristina Selthofer-Relatić

Aim To determine the eff ect of hypoxic mesenchymal stem cells (MSCs) on the interleukin (IL)-10 and interferon (IFN)-gamma in peripheral blood mononuclear cells (PBMCs) from systemic lupus erythematosus (SLE) patients.Methods This study used a post-test control group design. Hypoxic MSCs were isolated and characterized according to their surface m...

By Yan Wisnu Prajoko, Agung Putra, Ardi Prasetio, Nur Dina Amalina

Aim To investigate the association between type 2 diabetes mellitus (T2DM) and pulmonary embolism, as well as to determine the prognostic value of troponin, D-dimer, prothrombotic, and proinflammatory markers in patients with T2DM.Methods The retrospective cohort study included 305 patients with pulmonary embolism, divided into two groups: the firs...

By Jasmina Bošnjić