Aim To investigate the role of cordonal blood platelet-rich plasma (PRP) intra-articular injections for treating the patients with knee osteoarthritis in terms of procedure safety and clinical outcomes. Methods Twenty-five patients affected by knee osteoarthritis were enrolled and received one single intra-articular knee injection of umbilical cord PRP in a volume of 10 mL. A follow-up was investigated at time 0, 4, 8, 12 weeks and 6 months, evaluating clinical parameters and functional performances. Results No serious adverse events were identified. The paired ttest analysis showed a significant difference between baseline and each follow-up times for all clinical scales (p<0.05), with a significant improvement of clinical outcomes. Conclusion Allogeneic PRP can generate reliable therapeutic effect. The high content of tissue regenerative factors in cord blood platelets makes cordonal blood one of the ideal sources of PRP.
Lawrence R, Felson D, Helmick C, Arnold L, Choi H, Deyo R, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008. p. 26-e35.
2.
Schuster P, Schulz M, Mayer P, Schlumberger M, Immendoerfer M, Richter J. Open-wedge high tibial osteotomy and combined abrasion/microfracture in severe medial osteoarthritis and varus malalignment: 5-year results and arthroscopic findings after 2 years. Arthroscopy. 2015. p. 1279-1e88.
3.
Gore M, Tai K, Sadosky A, Leslie D, Stacey B. Clinical comorbidities, treatment patterns, and direct medical costs of patients with osteoarthritis in usual care: A retrospective claims database analysis. J Med Econ. 2011. p. 497–507.
4.
Mckenna M, Michaud C, Murray C, Marks J. Assessing the burden of disease in the United States using disability-adjusted life years. Am J Prev Med. 2005. p. 415–23.
5.
Yamada Y, Ito K, Nakamura S, Ueda M, Nagasaka T. Promising cell-based therapy for bone regeneration using stem cells from deciduous teeth, dental pulp, and bone marrow. Cell Transplant. 2011. p. 1003–13.
6.
Liu Q, Niu J, Huang J, Ke Y, Tang X, Wu X, et al. Knee osteoarthritis and all-cause mortality: The Wuchuan Osteoarthritis Study. Osteoarthr Cartil. 2015. p. 1154–7.
7.
Ogura T, Mosier B, Bryant T, Minas T. A 20-year follow-up after first-generation autologous chondrocyte implantation. Am J Sport Med. 2017. p. 2751–61.
8.
Diekman B, Wu C, Louer C, Furman B, Huebner J, Kraus V, et al. Intraarticular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ super healer mice prevents posttraumatic arthritis. Cell Transplant. 2013. p. 1395–408.
9.
Horie M, Choi H, Lee R, Reger R, Ylostalo J, Muneta T, et al. Intraarticular injection of human mesenchymal stem cells (MSCs) promotes rat meniscal regeneration by being activated to express Indian hedgehog that enhances expression of type II collagen. Osteoarthritis Cartilage. 2012. p. 1197–207.
10.
Ehrenfest D, Pinto D, Pereda N, Jimenez A, Corso P, Kang M, et al. The impact of the centrifuge characteristics and centrifugation protocols on the cells, growth factors, and fibrin architecture of a leukocyte-and platelet-rich fibrin (L-PRF) clot and membrane. Platelets. 2018. p. 171–84.
11.
Murphy M, Blashki D, Buchanan R, Yazdi I, Ferrari M, Simmons P, et al. Adult and umbilical cord blood-derived platelet-rich plasma for mesenchymal stem cell proliferation, chemotaxis, and cryo-preservation. Biomaterials. 2012. p. 5308–16.
12.
Mendonça-Caridad J, Juiz-Lopez P, Rubio-Rodriguez J. Frontal sinus obliteration and craniofacial reconstruction with platelet rich plasma in a patient with fibrous dysplasia. Int J Oral Maxillofac Surg. 2006. p. 88–91.
13.
Whitman D, Berry R, Green D. Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J Oral Maxillofac Surg. 1997. p. 1294–9.
14.
Matras H. Effect of various fibrin preparations on reimplantation in the rat skin. Osterr Z Stomatol. 1970. p. 338–59.
15.
Marx R, Carlson E, Eichstaedt R, Schimmele S, Strauss J, Georgeff K. Platelet-rich plasma -Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998. p. 638–46.
16.
Xie X, Zhang C, Tuan R. Biology of plateletrich plasma and its clinical application in cartilage repair. Arthrit Res Ther. 2014. p. 204.
17.
Filardo G, Matteo D, B, Martino D, Merli A, Cenacchi M, et al. Platelet-rich plasma intra-articular knee injections show no superiority versus viscosupplementation: a randomized controlled trial. Am J Sports Med. 2012. p. 1575–82.
18.
Laver L, Marom N, Dnyanesh L, Mei-Dan O, Espregueira-Mendes J, Gobbi A. PRP for degenerative cartilage disease: a systematic review of clinical studies. Cartilage. 2017. p. 341–64.
19.
Zhang ZY, Huang AW, Fan J, Wei K, Chen J, Li B, et al. The potential use of allogeneic platelet-rich plasma for large bone defect treatment: immunogenicity and defect healing efficacy. Cell Transplant. 2013. p. 175–87.
20.
Rebulla P, Pupella S, Santodirocco M, Greppi N, Villanova I, Buzzi M, et al. Multicentre standardisation of a clinical grade procedure for the preparation of allogeneic platelet concentrates from umbilical cord blood. Blood Transfus. 2016. p. 73–9.
21.
Kellegren J, Lawrence J. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 2000. p. 494–502.
22.
Gould D. Visual Analogue Scale (VAS). J Clin Nurs. 2001. p. 697–706.
23.
Roos E, Roos H, Lohmander L, Ekdahl C, Beynnon B. Knee Injury and Osteoarthritis Outcome Score (KOOS)--development of a self-administered outcome measure. J Orthop Sports Phys Ther. 1998. p. 88–96.
24.
Padua R, Bondi R, Ceccarelli E, Bondi L, Romanini E, Zanoli G, et al. Italian version of the International Knee Documentation Committee Subjective Knee Form: cross-cultural adaptation and validation. Arthroscopy. 2004. p. 819–23.
25.
Petrungaro P. Using platelet-rich plasma to accelerate soft tissue maturation in esthetic periodontal surgery. Compend Contin Educ Dent. 2001. p. 729–32.
26.
Robiony M, Polini F, Costa F, Politi M. Osteogenesis distraction and platelet-rich plasma for bone restoration of the severely atrophic mandible: preliminary results. J Oral Maxillofac Surg. 2002. p. 630–5.
27.
Anitua E. Plasma rich in growth factors: preliminary results of use in the preparation of future sites for implants. Int J Oral Maxillofac Implants. 1999. p. 529–35.
28.
Valle D, Sammartino A, Marenzi G, Tia G, M, Di Lauro E, et al. Prevention of postoperative bleeding in anticoagulated patients undergoing oral surgery: use of platelet-rich plasma gel. J Oral Maxillofac Surg. 2003. p. 1275–8.
29.
Marx R. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004. p. 489–96.
30.
Bhanot S, Alex J. Current applications of platelet gels in facial plastic surgery. Facial Plast Surg. 2002. p. 27–33.
31.
Straum O. The optimal platelet concentration in platelet-rich plasma for proliferation of human cells in vitro-diversity, biases, and possible basic experimental principles for further research in the field: a review. Peer J. 2020. p. e10303.
32.
Jeong S, Han S, Kim W. Treatment of diabetic foot ulcers using a blood bank platelet concentrate. Plast Reconstr Surg. 2010. p. 944–52.
33.
Crovetti G, Martinelli G, Issi M, Barone M, Guizzardi M, Campanati B, et al. Platelet gel for healing cutaneous chronic wounds. Transfus Apher Sci. 2004. p. 145–51.
34.
Smrke D, Gubina B, Domanoviç D, Rozman P. Allogeneic platelet gel with autologous cancellous bone graft for the treatment of a large bone defect. Eur Surg Res. 2007. p. 170–4.
35.
Gubina B, Rožman P, Bišcević M, Dromanovic D, Smrke D. The influence of allogeneic platelet gel on the morphology of human long bones. Coll Antropol. 2014. p. 865–70.
36.
Bottegoni C, Giudici D, Salvemini L, Chiurazzi S, Bencivenga E, Gigante R, et al. Homologous plateletrich plasma for the treatment of knee osteoarthritis in selected elderly patients: an open-label, uncontrolled, pilot study. Ther Adv Musculoskelet Dis. 2016. p. 35–41.
37.
Rosso L, Parazzi V, Damarco F, Righi I, Santabrogio L, Rebulla P, et al. Pleural tissue repair with cord blood platelet gel. Blood Transf. 2014. p. 235–42.
38.
Tadini G, Pezzani L, Ghirardello S, Rebulla P, Esposito S, Mosca F. Cord blood platelet gel treatment of dystrophic recessive epidermolysis bullosa. BMJ Case Rep. 2015.
39.
Gelmetti A, Greppi N, Guez S, Grassi F, Rebulla P, Tadini G. Cord blood platelet gel for the treatment of inherited epidermolysis bullosa. Transfus Apher Sci. 2018. p. 370–3.
40.
Piccin A, Rebulla P, Pupella S, Tagnin M, Marano G, Pierro D, et al. Impressive tissues regeneration of severe mucositis post stem cell transplantation using cord blood platelet gel. Transfusion. 2017. p. 2220–4.
41.
Volpe P, Marcuccio D, Stilo G, Alberti A, Foti G, Volpe A, et al. Efficacy of cord blood platelet gel application for enhancing diabetic foot ulcer healing after lower limb revascularization. Semin. Vasc. Surg. 2017. p. 106–12.
42.
Bisceglia G, Santodirocco M, Faienza A, Mastrodonato N, Urbano F, Totaro A, et al. First endocavitary treatment with cord blood platelet gel for perianal fistula. Regen Med. 2020. p. 1171–6.
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