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Review paper

Current status of localized submental fat treatment with sodium deoxicolate (ATX-101)

By
Cristina Ibáñez-Vicente Orcid logo ,
Cristina Ibáñez-Vicente
Contact Cristina Ibáñez-Vicente

Department of General Medicine, "Hospital de Getafe”, Madrid, Spain

Miguel Carrato-Gomez ,
Miguel Carrato-Gomez

Division of Orthopaedics and Trauma Surgery, “Complejo Hospitalario Universitario de Toledo", Toledo, Spain

Luigi Meccariello ,
Luigi Meccariello

Division of Anaesthesia, Analgesia and Intensive Care and Pain Therapy, Department of Emergency and Major Trauma, "Ospedali Riuniti di Ancona", Ancona, Italy

Umberto Ripani ,
Umberto Ripani

Division of Anaesthesia, Analgesia and Intensive Care and Pain Therapy, Department of Emergency and Major Trauma, "Ospedali Riuniti di Ancona", Ancona, Italy

Michele Bisaccia
Michele Bisaccia
Contact Michele Bisaccia

Orthopaedics and Traumatology Unit, Department of Surgical and Biomedical Science, S.M. Misericordia Hospital, University of Perugia, Sant'Andrea delle Fratte, Perugia, Italy

Abstract

Aim
Facial aesthetics is at present a concept intricately linked to the degree of self-esteem. Unwanted submental fat (SMF) leads to an unattractive submental profile. Sodium deoxicolate (ATX) -101 is the only injectable drug approved to decrease submental fat of moderate to severe intensity.
Methods
We carried out a bibliographic review in PubMed using the key words: deoxycholic acid, ATX-101, and submental fat.
Only complete articles published between 2009 and 2019, and focused on submental fat were reviewed, excluding those articles relating to that spoke of deoxycholate in the treatment of fat in other locations or in which deoxycholate was associated with other drugs.
Results
In several phase III clinical trials, injection of 2 mg/cm2 deoxycholic acid in SMF has reduced moderate-severe fullness compared to the placebo group. These results were maintained in most cases during a long follow-up period. Injections of
deoxycholic acid are generally well tolerated, with limited adverse effects in the treatment area, with a mild and complete resolution without sequelae. However, not all patients with SMF are suitable for deoxycholic acid therapy, and therefore a proper selection is very important to achieve the desired aesthetic results.
Conclusion
Deoxycholic acid injections are effective and are a generally well-tolerated, minimally invasive option for the treatment
of moderate to severe intensity SMF in selected adults.

References

1.
Schlessinger J, Weiss S, Jewell M, Narurkar V, Weinkle S, Gold M, et al. Perceptions and practices in submental fat treatment: a survey of physicians and patients. Skinmed. 2013. p. 27–31.
2.
Georgesen C, Lipner S. The development, evidence, and current use of ATX-101 for the treatment of submental fat. J Cosmet Dermatol. 2017. p. 174–9.
3.
Honigman R, Castle D. Aging and cosmetic enhancement. Clin Interv Aging. 2006. p. 115–9.
4.
Rotunda A, Suzuki H, Moy R, Kolodney M. Detergent effects of sodium deoxycholate are a major feature of an injectable phosphatidylcholine formulation used for localized fat dissolution. Dermatol Surg. 2004. p. 1001–8.

Citation

Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

 

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