Correlation of signal to noise ratio (SNR) value on distortion product otoacoustic emission (DPOAE) and expression of nuclear factor erythroid 2-related factor 2 (NRF2) in cochlear organ of Corti in rat exposed to noise
Aim To investigate the changes in the value of the signal to noise ratio (SNR) and to assess changes in the expression of nuclear factor erythroid 2-related factor 2 (NRF2) in the organ of Corti of rat exposed to noise. Methods This study used a randomized post test only control group laboratory experimental design with 27 male Wistar strain Rattus norvegicus. The study group was divided into 3 groups (n = 9): group I (control), group 2 (2 hours of 100 dB noise exposure) and group 3 (2 hours of 110 dB noise exposure). Results There was no significant difference in the SNR in the group 1 on day 0, 2 and 4 (p>0.05). However, there was a significant difference in the SNR in the group 2 and the group 3 on day 0, 2 and 4 (p<0.05). There was a significant difference in the mean levels of NRF2 expression in the cochlear organ of Rattus norvegicus in all groups (p<0.05). There was no correlation between the SNR and the NRF2 expression in group 2 (p> 0.05), but there was a correlation between the SNR and the NRF2 expression in the group 3 (p<0.05). Conclusion There was found a correlation between the SNR value on distortion product otoacoustic emission (DPOAE) examination and NRF2 expression in the cochlear organ of Corti of Rattus norvegicus exposed to 110 dB noise.
Basner M, Babisch W, Davis A, Brink M, Clark C, Janssen S, et al. Auditory and non-auditory effects of noise on health. Lancet. 2014;1325–32.
2.
Situation Review and Update on Deafness, Hearing Loss and Intervention Programmes. 2007;
3.
Kim M, Kwak S, Baek H, Li Z, Choe S, Song K. Protective effect of Yang Mi Ryung extract on noiseinduced hearing loss in mice. Evid Based Complementary Altern Med. 2017;9814836.
4.
Sliwinska-Kowalska M, Zaborowski K. WHO Environmental noise guidelines for the european region: A systematic review on environmental noise and permanent hearing loss and tinnitus. Int J Environ Res Public Health. 2017;1139.
5.
Le T, Straatman L, Lea J, Westerberg B. Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options. J Otolaryngol Head Neck Surg. 2017;41.
6.
Honkura Y, Matsuo H, Murakami S, Sakiyama M, Mizutari K, Shiotani A, et al. NRF2 is a key target for prevention of noise-induced hearing loss by reducing oxidative damage of cochlea. Sci Rep. 2016;19329.
7.
Li C, Cheng L, Wu H, He P, Zhang Y, Yang Y, et al. Activation of the KEAP1-NRF2-ARE signalling pathway reduces oxidative stress in hep2 cells. Mol Med Rep. 2018;2541–50.
8.
Ma Q. Role of NRF2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol. 2013;401–26.
9.
Hosokawa K, Hosokawa S, Ishiyama G, Ishiyama A, Lopez I. Immunohistochemichal localization of NRF2 in the human cochlea. Brain Res. 2018;1–8.
10.
Hearing loss due to recreational exposure to loud sounds: a review. 1AD;
11.
Helleman H, Elsing H, Limpens J, Dreschler W. Otoacoustic emission versus sudiometry in monitoring hearing loss after long term noise exposure-a systematic review. Scand J Work Environ Health. 2018;585–600.
12.
Mehrparvar A, Mirmohammadi S, Davari M, Mostaghachi M, Mollasadeghi A, Rahaloo M, et al. Conventiomal audiometry, extended high-frequency audiometry, and DPOAE for early diagnosis of NIHL. Iran Red Crescent Med J. 2014;9628.
13.
mittee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the care and use of laboratory animals. 2014;1–220.
14.
Czogalla B, Kahaly M, Mayr D, Schmoeckel E, Niesler B, Kolben T, et al. Interaction of ER and NRF2 impacts survival in ovarium cancer patients. Int J Mol Sci. 2019;112.
15.
Moussavi-Najarkola S, Khavanin A, Mirzaei R, Salehnia M, Muhammadnejad A, Akbari M. Temporary and permanent level shifts in distortion product otoacoustic emission following noise exposure in an animal model. Int Occup Environ Med. 2012;145–52.
16.
Grondin Y, Bortoni M, Sepulveda R, Ghelfi E, Bartos A, Cotanche D, et al. Genetic polymorphisms associated with hearing threshold shift in subjects during first encounter with occupational impulse noise. PlosOne. 2015;130827.
17.
Hybertson B, Gao B, Bose S, Mccord J. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011;234–46.
18.
Urono A, Motohashi H. The Keap1-Nrf2 system as an in vivo sensor for electrophiles. Nitric Oxide. 2011;153–60.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
,
