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Review paper

An epidemiological study of neuroendocrine tumours at tertiary hospitals in Bosnia and Herzegovina

By
Maja Konrad Čustović Orcid logo ,
Maja Konrad Čustović
Contact Maja Konrad Čustović

Pathology Department, Polyclinic for Laboratory Diagnostics, University Clinical Centre of Tuzla, Tuzla, Bosnia and Herzegovina

Ermina Iljazović ,
Ermina Iljazović

Pathology Department, Polyclinic for Laboratory Diagnostics, University Clinical Centre of Tuzla, Tuzla, Bosnia and Herzegovina

Azra Sadiković ,
Azra Sadiković

Pathology Department, Polyclinic for Laboratory Diagnostics, University Clinical Centre of Tuzla, Tuzla, Bosnia and Herzegovina

Zinaida Karasalihović
Zinaida Karasalihović

Pathology Department, Polyclinic for Laboratory Diagnostics, University Clinical Centre of Tuzla, Tuzla, Bosnia and Herzegovina

Abstract

Aim
Neuroendocrine neoplasms (NENs) are a heterogeneous group of tumours with varying clinical expression and behaviour. Because of indolent behaviour of NENs, reviewing and evaluation of epidemiological characteristics is a challenge. The aim of this study was to assess prevalence of NENs at tertiary hospitals considering age, gender, location, and grade.
Methods
Electronic files were used for a retrospective assessment of the patients with NENs of the gastroenteropancreatic tract and
bronchopulmonary system in tertiary hospitals in Bosnia and Herzegovina over the past 15 years (2005-2020).
Results
Among 438 patients, 291(66.4%) were males and 147 (33.6%) females; the median age was 62 years. The lungs were
the most frequent site, 304 (69.4%), followed by the pancreas, 22 (5.0%), colon, 14 (3.2%), stomach, 13 (2.9%), appendix,
13 (2.9%), rectum,11 (2.5%), small intestine, eight (1.8%) and gallbladder, one (0.2%). Metastases were most frequently found in the liver, 35 (8%) and lymph nodes, 15 (3.42%).
Conclusion
The results were largely consistent with those in literature, including age, gender, location, and the degree of differentiation. Most metastases originated from high-grade tumours and greater impairment of the liver.

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