Aim To analyse the impact of the length of antiviral therapy with tenofovir disoproxil fumarate (TDF) on the renal function in patients with chronic hepatitis B (CHB).Methods A cross-sectional study included 75 patients with CHB treated with tenofovir, who had a normal renal function at the beginning of the treatment. Renal function was determined ...

By Nerma Čustović, Lejla Alić, Ismar Rašić, Aida Saray, Amila Mehmedović, Nadža Zubčević

Aim Significant risk factors for femoral nail cutout are well-documented, primarily in the context of single-screw proximal nails.However, it remains uncertain whether those same risk factors are applicable when considering different implant devices. The aim of this retrospective cohort study was to compare cutout risk factors between single- versu...

By Michele Coviello, Antonella Abate, Giovanni Vicenti, Francesco Ippolito, Vittorio Nappi, Andrea Michele Abbaticchio, Elio Caiaffa, Giulia Colasuonno, Vincenzo Caiaffa, Giuseppe Solarino

Aim To assess machine-learning models, their methodological quality, compare their performance, and highlight their limitations.Methods The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations were applied. Electronic databases Science Direct, MEDLINE through (PubMed, Google Scholar), EBSCO, ERIC, and CINAHL w...

By Eslam Bani Mohammad, Muayyad Ahmad

Functional gastrointestinal disorders in childhood (FGIDs) constitute a significant time-consuming clinical problem for healthcare practitioners, and they carry an important psychosocial burden for patients and their families. The aim of this study was to characterize etiology, clinical features, and interventions in a paediatric cohort of patients...

By Amela Selimović, Nina Mekić, Selma Terzić, Almira Ćosićkić, Evlijana Zulić, Majda Mehmedović

Aim To investigate the effects of estrogen-related events (age at menopause, age at menarche) on later-life skeletal fragility in Bosnian postmenopausal women.Methods A total of 100 postmenopausal Bosnian women, aged between 55 and 75 years, were included. The women in the study group (n=50) had fragility fractures, and in the control group (n=50) ...

By Amila Kapetanović, Gordan Bajić, Sabina Sarić, Rubina Alimanović-Alagić, Martina Bonić, Dženan Pleho

Aim To investigate the prevalence of familial hypercholesterolemia in patients with acute coronary syndrome (ACS).Methods The study included fifteen patients with first or repeated ACS and treated/nontreated dyslipidaemia admitted to the Department of Cardiovascular Diseases of Clinical Hospital Centre Osijek between 1 January 2020 and 1 January 20...

By Željka Dragila, Matea Lozert, Silvija Canecki-Varžić, Kristina Selthofer-Relatić

Aim To investigate whether the use of ion resonance and bromelain-vitamin C or bromelain-vitamin C is the best to prevent ankle complications in post operative bimalleolar surgery.Methods A total of 61 patients treated with bimalleolar surgery were enrolled. The patients were divided into three groups: thefirst group (n=22) treated only with the su...

By Luigi Meccariello, Anna Iolanda Bello, Giovanni Bove, Nicola Gagliardo, D’Anna Raffaele, Luigi Matera

Aim To evaluate patient satisfaction with primary healthcare services and determine effectiveness indicators within Kazakhstan's compulsory health insurance system.Methods An analytical observational study with cross-examination was conducted in Kazakhstan's primary healthcare (PHC) organizations. Patient satisfaction was assessed through a 35-item...

By Makhabbat Shurenova, Kuralbay Kurakbayev, Tleukhan Abildaev, Aigul Tazhiyeva

Aim To determine the eff ect of hypoxic mesenchymal stem cells (MSCs) on the interleukin (IL)-10 and interferon (IFN)-gamma in peripheral blood mononuclear cells (PBMCs) from systemic lupus erythematosus (SLE) patients.Methods This study used a post-test control group design. Hypoxic MSCs were isolated and characterized according to their surface m...

By Yan Wisnu Prajoko, Agung Putra, Ardi Prasetio, Nur Dina Amalina

Aim To investigate the association between type 2 diabetes mellitus (T2DM) and pulmonary embolism, as well as to determine the prognostic value of troponin, D-dimer, prothrombotic, and proinflammatory markers in patients with T2DM.Methods The retrospective cohort study included 305 patients with pulmonary embolism, divided into two groups: the firs...

By Jasmina Bošnjić