Aim To analyse the ability of mesenchymal stem cells (MSCs) to regulate interleukin 6 (IL-6) and transforming growth factor (TGF-β) expression in vitro under co-culture conditions in human systemic lupus erythematosus (SLE). MethodThis study used a post-test group design that used peripheral blood mononuclear cells (PBMCs) from SLE patients at...

By Dewi Masyithah Darlan, Delfitri Munir, Nelva Karmila Jusuf, Agung Putra, Riyadh Ikhsan, Iffan Alif

Aim Chronic Suppurative Otitis Media (CSOM) with or without cholesteatoma is a global major problem and it is becoming a burden especially in developing countries. Studies have found that ethanol extracts of Puguntano leaves obtained by the percolation and socletation methods have phytochemical contents that provide anti-inflammatory effect. The ai...

By Harry A. Asroel, Aznan Lelo, Delfitri Munir, Jenny Bashiruddin, Restu Syamsul Hadi

Aim ABO blood group genotypes are established as a genetic factor in pathophysiology of various diseases, such as cardiovascular disorders, cancers, infectious diseases and there is rising evidence of their involvement in other conditions. The aim of this study was to determine if ventilatory changes of lung function in asthma, measured by biomarke...

By Marina Lampalo, Irena Jukić, Jasna Bingulac-Popović, Hana Safić Stanić, Nikola Ferara, Sanja Popović-Grle

Aim To present characteristics of collecting autologous peripheral blood stem cells over a one-year period with an emphasis on efficiency and safety. Methods A retrograde analysis of 24 leukapheresis in 20 adult patients with malignant haematological diseases in the Blood Transfusion Institute of the Federation of Bosnia and Herzegovina in Sarajevo...

By Gorana Ahmetović-Karić, Elma Ćatović-Baralija, Alma Sofo-Hafizović

Aim Multifragmentary segmental femoral shaft fracture is a high energy injury frequently associated with life-threatening conditions. The aim of this study was to compare the use of bio metallic open reduction internal fixation (ORIF) (plate with allograft bone strut) with minimally invasive plate osteosynthesis (MIPO) fixation for the treatment of...

By Giuseppe Rollo, Mario Ronga, Enrico Maria Bonura, Rocco Erasmo, Michele Bisaccia, Paolo Pichierri, Antonio Marsilio, Andrea Pasquino, David Gomez Garrido, Raffaele Franzese, Andrea Schiavone, Luigi Meccariello

Aim To investigate quality of life and exposure to lifestyle risk factors of cancer patients in Bosnia and Herzegovina and a correlation of cancer type with lifestyle risk factors. Methods This was a cross-sectional study conducted on 200 cancer patients from the Clinical Centre of the University of Sarajevo. The respondents completed an anonymous ...

By Nejra Mlačo, Armin Šljivo, Ahmed Mulać, Amina Kurtović-Kozarić, Anes Pašić, Semir Bešlija, Šejla Cerić, Timur Cerić

Aim To determine the role of endothelin (ET)-1 in predicting hepatopulmonary syndrome (HPS) in patients with liver cirrhosis. Methods A cross sectional study involving 80 liver cirrhosis patients aged 18 years or older was conducted in Adam Malik General Hospital Medan, Indonesia between July 2017 and June 2018. HPS diagnosis was confirmed from the...

By Dr Darmadi, Riska Habriel Ruslie

Aim To determine a status of systolic function in patients with diabetes mellitus (DM) type 2 with ST-segment elevation acute myocardial infarction (STEMI), to determine values of cardiac biomarkers in patients with DM type 2 with STEMI and correlate the parameters with ejection fraction of left ventricle (EFLV). Methods A total of 80 patients were...

By Mirela Halilčević, Edin Begić, Alen Džubur, Nirvana Šabanović-Bajramović, Mevludin Mekić, Malik Ejubović, Amela Džubur, Ena Štimjanin

Aim To investigate CD133 expression and its relationship to clinicopathological profile in colorectal cancer (CRC) patients.Methods This cross-sectional study was performed at the Internal Medicine Department, School of Medicine, Adam Malik GeneralHospital. The colorectal cancer tissue was taken from surgical resection and colonoscopy biopsy from C...

By Imelda Rey, Agung Putra, Dharma Lindarto, Fauzi Yusuf

Aim To assess endothelial nitric oxide synthase (eNOS) gene (G894T) polymorphism and nitric oxide (NO) level in hypertensive diabetic Bataknese patients.Methods A hospital-based, case control study (hypertensive and normotensive diabetic patient) was conducted. Genotyping ofeNOS gene (G894T) was done using polymerase chain reactionrestriction fragm...

By Jelita Siregar, Ratna Akbari Ganie, Dharma Lindarto, Erna Mutiara, Delfitri Munir