Home Current Archive Editorial Team
About us
About Author Guidelines Aims and scope
News Contact
×
Home Current Archive Editorial board

About Author Guidelines Aims and scope
News Contact
Review paper
Published: 22.09.2019. Biochemistry
<< Prev | Next >>
PDF
https://doi.org/10.17392/1068-20

The effect of bay leaf extract Syzygium polyanthum (Wight) Walp. on C-reactive protein (CRP) and myeloperoxidase (MPO) level in the heart of rat model of myocardial infarction

By
Refli Hasan Orcid logo ,
Refli Hasan
Contact Refli Hasan

Department of Internal Medicine, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia

View authors publications

Search this author on:

PubMed | Google Scholar
Dharma Lindarto ,
Dharma Lindarto

Department of Internal Medicine, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia

View authors publications

Search this author on:

PubMed | Google Scholar
Gontar Alamsyah Siregar ,
Gontar Alamsyah Siregar

Department of Internal Medicine, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia

View authors publications

Search this author on:

PubMed | Google Scholar
Zulfikri Mukhtar
Zulfikri Mukhtar

Department of Cardiology, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia

View authors publications

Search this author on:

PubMed | Google Scholar

Abstract

Aim
To study the anti-inflammatory effect of bay leaf on C-reactive protein (CRP) and myeloperoxidase (MPO) level in the heart of rat model with myocardial infarction.
Methods
In the first phase, results of pathological examination and biochemical assay were compared between rats with and without induction of myocardial infarction. In the second phase, the effect of bay leaf extract on CRP and MPO of rats with myocardial infarction was studied.
Results
 C-reactive protein and MPO were higher in rats which had myocardial infarction. Administration of bay leaf extract reduced levels of CRP and MPO in the rats started from day 4 after the induction of myocardial infarction.
Conclusion
 Anti-inflammatory effect of bay leaf is confirmed, reflected by decreasing of CRP and MPO levels of rat model with myocardial infarction.

Keywords:

bay leaf,
myocardial infarction,
inflammation

References

1.
Cardiovascular Diseases. World Health Organization. World Health Organization; 2017.
2.
Indonesia: WHO statistical profile. World Health Organization. World Health Organization; 2012.
3.
Davi G, Carlo. Platelet activation and atherothrombosis. N Engl J Med. 2007. p. 2482–94.
4.
Choi S, Mintz G. What have we learned about plaque rupture in acute coronary syndromes? Curr Cardiol Rep. 2010. p. 338–43.
5.
Libby P. Inflammation in atherosclerosis.Arterioscler Thromb Vasc. Biol. 2012. p. 2045–51.
6.
Hackam D, Anand S. Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. J Am Med Assoc. 2003. p. 932–40.
7.
Meier-Ewert H, Ridker P, Rifai N, Price N, Dinges D, Mullington J. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects. Clin Chem. 2001. p. 426–30.
8.
Lörchner H, Widera C, Hou Y, Elsässer A, Warnecke H, Giannitsis E, et al. Reg3β is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome. Int J Cardiol. 2018. p. 7–13.
9.
Omran M, Zahran F, Kadry M, Belal A, Emran T. Role of myeloperoxidase in early diagnosis of acute myocardial infarction in patients admitted with chest pain. J Immunoassay Immunochem. 2018. p. 337–47.
10.
Rudolph V, Goldmann B, Bös C, Rudolph T, Klinke A, Friedrichs K, et al. Diagnostic value of MPO plasma levels in patients admitted for suspected myocardial infarction. Int J Cardiol. 2011. p. 267–71.
11.
Novira P, Febrina E. Tinjauan aktifitas farmakologi ekstrak daun salam (Syzgium polyanthum (Wight) Walp). Farmaka. 2018. p. 288–97.
12.
Harismah K, Chusniatun. Utilization of bay (Eugenia polyantha) leaves as herbal medicines and food flavoring. Warta LPM. 2016. p. 110–8.
13.
Wu Y, Yin X, Wijaya C, Huang M, Mcconnell B. Acute myocardial infarction in rats. J Vis Exp. 2011. p. 2464.
14.
Syahreza A, Syafril S, Lindarto D. Comparison of sambiloto (Andrographis paniculata (Burm.f.) Nees) and Salam (Syzygium polyanthum (wight) walp) extract mixture with simvastatin on ferritin concentration in dyslipidemic patients. J Med Plants Stud. 2018. p. 4–7.
15.
Chang J, Nair V, Luk A, Butany J. Pathology of myocardial infarction. Diagn Histopathol. 2013. p. 7–12.
16.
Hashmi S, Salam A, S. Acute myocardial infarction and myocardial ischemia-reperfusion injury: a comparison. Int J Clin Exp Pathol. 2015. p. 8786–96.
17.
Agustina R, Indrawati D, Masruhim M. Aktivitas Ekstrak Daun Salam (Eugenia polyantha) Sebagai Antiinflamasi Pada Tikus Putih (Rattus norvegicus). J Trop Pharm Chem. 2015. p. 120–3.
18.
Liliwirianis N, Musa N, Zain W, Kassim J, Karim S. Preliminary Studies on phytochemical screening of ulam and fruit from Malaysia. E-J Chem. 2011. p. 285–8.
19.
Prahastuti S, Tjahjani S, Hartini E. Effect of bay leaf (Syzygium polyanthum) infusion on reduction in total blood cholesterol levels in wistar rats with dyslipidemia. Jurnal Medika Planta. 2011. p. 29–32.
20.
Sutrisna E, Nuswantoro Y, Said R. Hypolipidemic of ecthanolic extract of Salam bark (Syzygium polyanthum (Wight) Walp.) from Indonesia (Preclinical study). Drug Invent Today. 2018. p. 55–8.

Citation

Copyright

Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

 

Article metrics

Google scholar: See link

{{ submission.title }}
Issue image
Vol 17, Issue 1, 2020
Digital dermatoglyphics in the evaluation of the genetic basis of breast cancer in Bosnian-Herzegovinian population - quantitative analysis Comparison of intubation condition and the quality of muscle relaxation between rocuronium and vecuronium using „timing principle“ Bone marrow adiposity is inversely associated with bone mineral density in postmenopausal females Fetuin-A Thr256Ser gene polymorphism as a mortality predictor in patients with chronic kidney disease on maintenance haemodialysis in Medan, Indonesia The relation between BRAFV600E mutation and clinicopathological characteristics of papillary thyroid cancer See full issue

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.