Aim Triple negative breast cancer cells (TNBC) are the population of breast cancer cells that are responsible for cancer recurrence and apoptosis resistance. Unfortunately, current therapies have limited efficacy to TNBC population due to apoptosis resistance and chemoresistance. Tumour suppressor p53 and survivin are primary targets for TNBC thera...

By Deryne Anggia Paramita, Dedy Hermansyah, Desiree Anggia Paramita, Nur Dina Amalina

Aim Knee osteoarthritis is a common osteoarthritis, which limits individual’s activity and affects aspects of daily life and quality of life. The prevalence of osteoarthritis in Indonesians is still high, reaching 12.7% in women and 15.8% in men. Based on the WHO, the prevalence of osteoarthritis in the world is still high, with 18% in women ...

By Panji Sananta, Avicenna Rahmanda, Dhelya Widasmara, Eka Noviya Fuzianingsih

Aim To determine the value of IFN (intzerferon)-α in the patients with systemic lupus erythematosus (SLE) and to correlate IFN-αwith values of non-specific biochemical parameters of inflammation (C-reactive protein, leukocytes values, erythrocyte sedimentation rate, albumins and globulins).Methods Research included 55 patients with SLE ...

By Lamija Zečević, Edin Begić, Buena Aziri, Izeta Aganović - Mušinović

Aim To investigate the role of short-term diazepam therapy for improving long-term outcomes and reducing neck pain after whiplash injury.Methods A total of 89 patients suffering from whiplash injury were included. They were randomly assigned into 2 groups: groupA (study group), and group B (control group). The test group was prescribed with diazepa...

By Edin Mešanović, Ćamil Habul, Ermin Hadžić

Aim To investigate the relationship between adherence to preventive behaviors and risk of COVID-19 infection.Methods In this case-control study, 491 participants were selected through convenience sampling. First, the samples of the casegroup (COVID-19 patients) were selected, and then the control group was matched with the case group based on age, ...

By Reza Hosseinabadi, Shoorangiz Biranvand, Khatereh Anbari

Aim Given the impact of vascular comorbidities (VC) on the diagnosis, treatment, and outcome of multiple sclerosis (MS), weexamined the incidence and correlation of VC and risk factors for vascular disease in people with MS (PwMS) compared to the general population, and the impact on the physical disability of patients.Methods Cross-sectional study...

By Daliborka Tadić, Sanja Grgić, Aleksandra Dominović-Kovačević, Majda Nazalević-Bursać, Srđan Mavija, Vlado Đajić

Aim The infection of the SARS-CoV-2 virus potentially causes a cytokine storm with elevated IL-6 and IL-1β levels. Statin therapy was common among COVID-19 patients due to their cardiovascular comorbidities. However, the effect of statins on COVID-19 infection is unclear. The aim of this study was to evaluate the impact of statin administratio...

By Andrianto Andrianto, Budi Susetyo Pikir, Rizki Amalia, Teuku Yusriza, Fatimah Alzahra, Maya Qurota A’yun, Michael Jonatan

Aim Several biomarkers are currently used as diagnostic and prognostic tools in patients with cancer. Soluble urokinase plasminogen activator receptor (suPAR) is elevated in acute and chronic inflammatory procedures and several observational studies during the last 20 years have investigated its role in oncology. The purpose of this article was to ...

By Themistoklis Paraskevas, Francesk Mulita, Christos Michailides, Georgios-Ioannis Verras, Elias Liolis, Eleousa Oikonomou, Ioannis Perdikaris, Panagiotis Perdikaris, Konstantinos Bouchagier, Ioannis Panagiotopoulos, Dimitrios-Ioannis Kasartzian, Dimitrios Filis, Levan Tchabashvili, Despoina Spyropoulou, Dimitrios Velissaris

Aim To evaluate the efficacy (rate of recanalization) of therapy with novel oral anticoagulants (NOAC; rivaroxaban, apixaban)compared to conventional treatment (low molecular weight heparin - LMWH and vitamin K antagonist) in the treatment of deep vein thrombosis (DVT) of the proximal segments of lower extremities.Methods The first group consisted ...

By Alden Begić, Edin Begić, Mirza Dilić, Svjetlana Loga - Zec, Nermina Babić, Refet Gojak, Armin Šljivo

Aim Knee osteoarthritis is a common osteoarthritis, which limits individual’s activity and affects aspects of daily life and quality of life. The prevalence of osteoarthritis in Indonesians is still high, reaching 12.7% in women and 15.8% in men. Based on the WHO, the prevalence of osteoarthritis in the world is still high, with 18% in women ...

By Panji Sananta, Avicenna Rahmanda, Dhelya Widasmara, Eka Noviya Fuzianingsih