Home Current Archive Editorial Team
About us
Aims and scope About Author Guidelines
News Contact
×
Home Current Archive Editorial board

Aims and scope About Author Guidelines
News Contact
Review paper
Received: 24.01.2022. >> Accepted: 10.03.2022. >> Published: 02.07.2022. Biochemistry
<< Prev | Next >>
PDF
https://doi.org/10.17392/1470-22

Interferon alpha and non-specific markers of inflammation in patients with systemic lupus erythematosus

By
Lamija Zečević Orcid logo ,
Lamija Zečević
Contact Lamija Zečević

Department of Clinic Biochemistry and Immunology, Clinical Centre, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Edin Begić ,
Edin Begić

General Hospital "Prim. dr. Abdulah Nakaš", Sarajevo, Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Buena Aziri ,
Buena Aziri

Sarajevo Medical School, Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Izeta Aganović - Mušinović
Izeta Aganović - Mušinović

Department for Immunology, School of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar

Abstract

Aim
To determine the value of IFN (intzerferon)-α in the patients with systemic lupus erythematosus (SLE) and to correlate IFN-α
with values of non-specific biochemical parameters of inflammation (C-reactive protein, leukocytes values, erythrocyte sedimentation rate, albumins and globulins).
Methods
Research included 55 patients with SLE diagnosis and a control group consisted of 25 healthy subjects (during period
2019-2020). IFN (Interferon)-α and non-specific biochemical parameters of inflammation were obtained using standard protocols.
Results
IFN-α values were independent of gender (p=0.95). The difference in serum IFN-α values in relation with the age in the
SLE group was statistically significant (p=0.036). Only serum globulin was significantly higher (p=0.0023) in IFN-α positive compared to IFN-α negative SLE patients. A statistically significant correlation between the values of IFN-α and globulin was proved (r=0.315; p=0.019). No significant correlation was found between other non-specific biochemical parameters and IFN-α values.
Conclusion
Increased IFN-α values were observed in younger patients, and the correlation between IFN and globulin was proved.

Keywords:

immunity,
inflammation,
interferon-alpha

References

1.
Connelly K, Morand E. Systemic lupus erythematosus: a clinical update. Intern Med J. 2021. p. 1219–28.
2.
Sarwar S, Mohamed A, Rogers S, Sarmast S, Kataria S, Mohamed K, et al. Neuropsychiatric systemic lupus erythematosus: a 2021 update on diagnosis, management, and current challenges. Cureus. 2021. p. 17969.
3.
Idborg H, Oke V. Parameter IFN-α. Int J Mol Sci. 2021. p. 11327.
4.
Leukocytes.
5.
Erythrocyte sedimentation rate (mm ⁄h).
6.
Table 1. Non-specific biochemical parameters of inflammation in relation to IFN-α values in patients with systemic lupus erythematosus (SLE).
7.
Chasset F, Arnaud L. Targeting interferons and their pathways in systemic lupus erythematosus. Autoimmun Rev. 2018. p. 44–52.
8.
Wittling M, Cahalan S, Levenson E, Rabin R. Shared and unique features of human interferon-beta and interferon-alpha subtypes. Front Immunol. 2021. p. 605673.
9.
Rönnblom L, Leonard D. Interferon pathway in SLE: one key to unlocking the mystery of the disease. Lupus Sci Med. 2019. p. 270.
10.
Rubio J, Kyttaris V. Measuring IFN activity in suspected SLE: a valuable step? Expert Rev Clin Immunol. 2021. p. 545–8.
11.
Uzkeser H, Keskin H, Haliloglu S, Cayir Y, Karaaslan Y, Kosar A, et al. Is mean platelet volume related to disease activity in systemic lupus erythematosus? Int J Clin Pract. 2021. p. e14676.
12.
Barber M, Drenkard C, Falasinnu T, Hoi A, Mak A, Kow N, et al. Global epidemiology of systemic lupus erythematosus. Nat Rev Rheumatol. 2021. p. 515–32.
13.
Vaillant J, Goyal A, Bansal A, Varacallo P, M. Systemic Lupus Erythematosus. Treasure Island. StatPearls Publishing; 2021.
14.
Enocsson H, Gullstrand B, Eloranta M, Wetterö J, Leonard D, Rönnblom L, et al. C-reactive protein levels in systemic lupus erythematosus are modulated by the interferon gene signature and CRP gene polymorphism rs1205. Front Immunol. 2021. p. 622326.
15.
He S, Tang C, Yu J, Ma J, Qiao M, Zhou W, et al. Combining C reactive protein and serum albumin to predict 90-day mortality in systemic lupus erythematosus with serious community-acquired infections. Lupus Sci Med. 2021. p. 505.
16.
Hernández-Martínez A, Gavilán-Carrera B, Vargas-Hitos J, Morillas-De-Laguno P, Sola-Rodríguez S, Rosales-Castillo A, et al. Ideal cardiovascular health in women with systemic lupus erythematosus: association with arterial stiffness, inflammation, and fitness. Int J Cardiol. 2021. p. 207–13.
17.
Mathian A, Koutouzov S. Interferon-alpha: a key cytokine in systemic lupus erythematosus pathogenesis. Rev Med Interne. 2008. p. 696–700.
18.
Niewold T, Clark D, Salloum R, Poole B. Interferon alpha in systemic lupus erythematosus. J Biomed Biotechnol. 2010. p. 948364.
19.
Cucak H, Yrlid U, Reizis B, Kalinke U, Johansson-Lindbom B. Type I interferon signaling in dendritic cells stimulates the development of lymph-noderesident T follicular helper cells. Immunity. 2009. p. 491–501.
20.
Reizis B, Colonna M, Trinchieri G, Barrat F, Gilliet M. Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? Nat Rev Immunol. 2011. p. 558–65.
21.
Kirou K, Gkrouzman E. Anti-interferon alpha treatment in SLE. Clin Immunol. 2013. p. 303–12.
22.
Abida R, Yeoh S, Isenberg D. Advances in systemic lupus erythematosus. Medicine. 2022. p. 7–17.
23.
Ito T, Kanzler H, Duramad O, Cao W, Liu Y. Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells. Blood. 2006. p. 2423–31.
24.
Lee J, Park J, Lee E, Lee E, Song Y. Circulating exosomes from patients with systemic lupus erythematosus induce a proinflammatory immune response. Arthritis Res Ther. 2016. p. 264.
25.
Riboldi P, Gerosa M, Moroni G, Radice A, Allegri F, Sinico A, et al. Anti-DNA antibodies: a diagnostic and prognostic tool for systemic lupus erythematosus. Autoimmunity. 2005. p. 39–45.
26.
Eudy A, Vines A, Dooley M, Cooper G. Parks CG. Elevated C-reactive protein and self-reported disease activity in systemic lupus erythematosus. Lupus. 2014. p. 1460–7.
27.
Draborg A, Lydolph M, Westergaard M, Larsen O, Nielsen S, Duus C, et al. Elevated concentrations of serum immunoglobulin free light chains in systemic lupus erythematosus patients in relation to disease activity, inflammatory status, B cell activity and Epstein-Barr virus antibodies. PLoS One. 2015. p. 138753.
28.
Almaghlouth I, Johnson S, Pullenayegum E, Gladman D, Urowitz M. Immunoglobulin levels in systemic lupus erythematosus: a narrative review. Lupus. 2021. p. 867–75.

Citation

Copyright

Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

 

Article metrics

Google scholar: See link

{{ submission.title }}
Issue image
Vol 19, Issue 2, 2022
Obstetric shock and shock in obstetrics – steady obstetrical syndrome Pheochromocytoma in pregnancy – a rare but dangerous diagnosis A comparison of different doses of fentanyl for patients undergoing elective colonoscopy: a randomized double-blind clinical trial The effect of statin administration on IL-6 and IL-1b expression in peripheral blood mononuclear cells of a hypertensive patient with SARS-CoV-2 spike protein stimulation Association between donor’s age and expression of cardiomyocyte marker quantity on adipocyte-derived mesenchymal stem cell See full issue

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.