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Review paper
Published: 02.07.2022. Biochemistry
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https://doi.org/10.17392/1499-22

Vascular comorbidities in patients with multiple sclerosis and their impact on physical disability

By
Daliborka Tadić Orcid logo ,
Daliborka Tadić
Contact Daliborka Tadić

Clinic of Neurology, University Clinical Centre of the Republic of Srpska, Banjaluka, Bosnia and Herzegovina

Department of Neurology, School of Medicine, University of Banja Luka, Banjaluka, Bosnia and Herzegovina

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Sanja Grgić ,
Sanja Grgić

Department of Neurology, School of Medicine, University of Banja Luka, Banjaluka, Bosnia and Herzegovina

Clinic of Neurology, University Clinical Centre of the Republic of Srpska, Banjaluka, Bosnia and Herzegovina

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Aleksandra Dominović-Kovačević ,
Aleksandra Dominović-Kovačević

Clinic of Neurology, University Clinical Centre of the Republic of Srpska, Banjaluka, Bosnia and Herzegovina

Department of Neurology, School of Medicine, University of Banja Luka, Banjaluka, Bosnia and Herzegovina

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Majda Nazalević-Bursać ,
Majda Nazalević-Bursać

Clinic of Neurology, University Clinical Centre of the Republic of Srpska, Banjaluka, Bosnia and Herzegovina

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Srđan Mavija ,
Srđan Mavija

Clinic of Neurology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina

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Vlado Đajić
Vlado Đajić

Clinic of Neurology, University Clinical Centre of the Republic of Srpska, Banja Luka, Bosnia and Herzegovina

Department of Neurology, School of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina

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Abstract

Aim
Given the impact of vascular comorbidities (VC) on the diagnosis, treatment, and outcome of multiple sclerosis (MS), we
examined the incidence and correlation of VC and risk factors for vascular disease in people with MS (PwMS) compared to the general population, and the impact on the physical disability of patients.
Methods
Cross-sectional study involved 100 patients with MS and 50 healthy people from the general population, matched by
sex and age. The values of demographic, biochemical, and anthropometric parameters, the presence of VC and risk factors for vascular diseases in both groups, and clinical parameters in PwMS were analysed. Statistical analysis included methods of descriptive statistics, χ2 test, Student's t-test, analysis of variance, correlation
and regression analysis.
Results
Groups differed by a higher frequency of transient ischemic attack in the control group (p=0.024), and the treatment of
hypertension (p=0.038) and smoking frequency (p=0.044) in the MS group. Normal triglycerides levels were statistically significantly more prevalent in the MS group (p=0.000). Total body weight and BMI were statistically significantly higher in the control group (p=0.000). The increase in Expanded Disability Status Scale (EDSS) score was associated with higher levels of total (p=0.001) and low-density lipoprotein (LDL) cholesterol (p=0.003), and activated partial thromboplastin time APTT (p=0.002).
Conclusion
In PwMS it is necessary to pay attention to the higher frequency of smoking than in general population, and the impact
of total cholesterol, LDL and APTT levels as significant parameters that affect physical disability.

Keywords:

cholesterol,
hypertension,
smoking,
vascular diseases

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