Aim Distal metastases to oral cavity are very rare. Adenocarcinoma, renal cell carcinoma (RCC) and squamous cell carcinoma are the most common metastatic tumours. The aim of this study was to assess the diagnostic relevance of metastatic renal cell carcinoma on tongue manifestations in large patient series. Methods A patient with distal RCC metastases to the tongue and neck lymph nodes as the first manifestations of malignancy was presented. Also, all reports described during 106-year period relating to distal RCC metastasis to the tongue were evaluated. Results In the presented patient, initial presentation of RCC was metastasis to the tongue. Three months after nephrectomy, tongue tumour resection and radical neck dissection were performed. Histopathological analysis confirmed RCC metastasis. Postoperatively, the patient underwent radiotherapy and polychemotherapy. Tongue metastasis from RCC is extremely rare with only 51 cases reported during the 106-year period. In only 7 patients tongue metastasis was reported as an initial presentation of RCC. Conclusion The RCC metastasizing to the tongue is extremely rare and thus it poses a diagnostic challenge especially when it is the first sign of malignancy. Therapeutic decisions should maximize patient comfort and minimize morbidity considering the poor long-term prognosis.
Van Der Waal R, Buter J, Van Der Waal I. Oral metastases: report of 24 cases. Br J Oral Maxillofac Surg. 2003. p. 3–6.
2.
Raiss H, Duplomb S, Tartas S, Layachi M, Errihani H. Lingual metastasis as an initial presentation of renal cell carcinoma: a case report. J Med Case Rep. 2017. p. 314.
3.
Mcclure S, Movahed R, Salama A, Ord R. Maxillofacial metastases: a retrospective review of one institution’s 15-year experience. J Oral Maxillofac Surg. 2013. p. 178–178.
4.
Shen M, Kang J, Wen Y, Ying W, Yi J, Hua C, et al. Metastatic tumors of the oral and maxillofacial region: A retrospective study of 19 cases in Western China and review of Chinese and English literature. J Oral Maxillofac Surg. 2009. p. 718–37.
5.
Sauerborn D, Vidakovic B, Baranovic M, Mahovne I, Danic P, Danic D. Gastric adenocarcinoma metastasis to the alveolar mucosa of the mandible. A case report and reviev of the literature. J Craniomaxillofac Surg. 2011. p. 645–8.
6.
Hirshberg A, Berger R, Allon I, Kaplan I. Metastatic tumors to the jaws and mouth. Head Neck Pathol. 2014. p. 463–74.
7.
Morales V, M, Parra T, J, Miguel C, J, et al. Right hemiparesis as presentation of renal cell carcinoma. An Med Interna. 2004. p. 359–60.
8.
Rhind S, Hawe C, Dixon P, Scudamore C. Oral metastasis of renal cell carcinoma in horse. J Comp Path. 1999. p. 97–103.
9.
Sachdeva K. Renal cell carcinoma. E-medicine. 2010.
10.
Griffin N, Gore M, Sohaib S. Imaging in metastatic renal cell carcinoma. Am J Roentgenol. 2006. p. 360–70.
11.
Serouya S, Dultz L, Concors S, Wang B, Patel K. Late solitary metastasis of renal cell carcinoma to the submandibular gland. J Oral Maxillofac Surg. 2012. p. 2356–9.
12.
Altuntas O, Petekkaya I, Suslu N, Gullu I. Renal cell carcinoma metastasis to the tongue: a case report and review of the literature. J Oral maxilofac Surg. 2015. p. 1227–30.
13.
Huang H, Chanmg K, Chen T, Wu K, Ueng S. Renal cell carcinoma metastases in the head and neck. Chang Gung Med J. 2006. p. 59–65.
14.
Zegarelli D, Tsukada Y, Pickren J, Greene G, Jr. Metastatic tumor to the tongue: Report of twelve cases. Oral Surg Oral Med Oral. Pathol. 1973. p. 202–11.
15.
Lang E, Patil N, Walsh R, Leader M, Walsh M. A case of renal cell carcinoma metastatic to the nose and tongue. Ear Nose Throat J. 2003. p. 382–3.
16.
Azam F, Abubakerr M, Gollins S. Tongue metastasis as an initial presentation of renal cell carcinoma: a case report and literature review. J Med Case Rep. 2008. p. 249.
17.
Friedmann I, Osborn D. Metastatic tumours in the ear, nose and throat region. J Laryngol Otol. 1965. p. 576–91.
18.
Mc Nattin R, Al D. A case of renal adenocar-cinoma with unusual manifestation. Am J Cancer. 1931. p. 1570.
19.
Schrag A, Jordan F. Unusual metastasis from primary hypernephroma. Can Med Assoc J. 1945. p. 168–9.
20.
Del Carmen B, Korbitz B. Oral metastasis from hypernephroma. J Am Geriatr Soc. 1970. p. 743–6.
21.
Satomi Y, Matsuura K, Ogawa H, Mori Y. Three cases of hypernephroma metastasis in the otorhinopharyngolaryngeal region (parotid gland, nasal cavity, tongue and gingiva). Jpn J Clin Urol. 1974. p. 611–6.
22.
Friedlander A, Singer R. Renal adenocarcinoma of the kidney with metastasis to the tongue. J Am Dent Assoc. 1978. p. 989–91.
23.
Fitzgerald R, Mcinnes B, Manry H. Renal cell carcinoma involving oral soft tissues. J Oral Maxillofac Surg. 1982. p. 604–6.
24.
Kitao K, Watanabe T, Miyamura K, Ishikawa K. Metastatic Granwitz tumor of the base of the tongue. A case report. Jibi Inkoka. 1986. p. 67–70.
25.
Matsumoto A, Iio S. Metastasis of renal cell carcinoma to the tongue: A case report. Nishinihon J Urol. 1987. p. 1147–9.
26.
Inai T, Kagawa S, Aga Y, Akiyama K. A renal cell carcinoma with metastasis to the tongue. Acta Urol Jpn. 1987. p. 1240–3.
27.
Kapoor V, Mukhopadhyay A, Chattopadhyay T, Sharma L. Renal cell carcinoma metastaic to tongue. J Ind Med Assoc. 1987. p. 119–20.
28.
Madison J, Frierson H. Pathology quiz case 2. Clear cell carcinoma, consistent with metastatic renal cell carcinoma. Arch Otolaryngol Head Neck Surg. 1988. p. 570–3.
29.
Ishikawa J, Morisue K, Imanishi O, Kamidono S. Renal cell carcinoma metastatic to tongue: A case report. Hinyokika Kiyo. 1991. p. 263–5.
30.
Okabe Y, Ohoka H, Miwa T, Nagayama I, Fukukawa M. View from beneath: pathology in focus. Renal cell carcinoma metastasis to the tongue. J Laryngol Otol. 1992. p. 282–4.
31.
Shibayama T, Hasegawa S, Nakamura S, Tachibana M, Jitsukawa S, Shiotani A. Disappearance of metastatic renal cell carcinoma to the base of the tongue after systemic administration of interferon-alfa. Eur Urol. 1993. p. 297–9.
32.
Ziyada W, Brookes J, Penman H. Expectorated tissue leading to diagnosis of renal adenocarcinoma. J Laryngol Otol. 1994. p. 1108–10.
33.
Airoldi M, Succo G, Valente G, Cavalot A, Gabriele P, Bumma C. Head and neck metastases of renal cancer after nephrectomy: a report of 2 cases. Tumori. 1995. p. 213–4.
34.
Aguirre A, Rinaggio J, Diaz-Ordaz E. Lingual metastasis of renal cell carcinoma. J Oral Maxillofac Surg. 1996. p. 344–6.
35.
Konya E, Hara Y, Umekawa T, Uejima S, Sugiyama T, Kurita T. Two cases of renal cell carcinoma detected by metastasis to another organ. Hinyokika Kiyo. 1997. p. 647–50.
36.
Tomita T, Inouye T, Shiden S, Mukai M. Palliative radiotherapy for lingual metastasis of renal cell carcinoma. Auris Nasus Larynx. 1998. p. 209–14.
37.
Navarro F, Vicente J, Villanueva M, Sanches A, Provencio M, Espana P. Metastatic renal cell carcinoma to the head and neck area. Tumori. 2000. p. 88–90.
38.
Fukuda M, Miyata M, Okabe K, Sakashita H. A case of 9 tumors metastatic to the oral and maxillofacial region. J Oral Maxillofacial Surg. 2002. p. 942–4.
39.
Pritchyk K, Schiff B, Newkirk K, Krowiak E, Deeb Z. Metastatic renal cell carcinoma to the head and neck. Laryngoscope. 2002. p. 1598–602.
40.
Mekni A, Bouraoui S, Touati S, El Ouertani L, El M. Linguinal metastasis from clear cell carcinoma of the kidney. Tunis Med. 2002. p. 570–3.
41.
Goel M, Williams D, Evans H, Roberts J. Lingual metastasis from renal cell carcinoma management and review of the literature. Urol Int. 2003. p. 418–21.
42.
Marioni G, Gaio E, Poletti A, Derosas H, Staffieri A. Uncommon metastatic site of renal adenocarcinoma: The oral tongue. Acta Otolaryngol. 2004. p. 197–201.
43.
Kyan A, Kato S. Renal cell carcinoma metastatic to the base of tongue: a case report. Hinyokika Kiyo. 2004. p. 791–3.
44.
Torres-Carranza E, Garcia-Perla A, Infante-Cossio P, Belmonte-Caro R, Loizaga-Iriondo J, Jl GP. Airway obstruction due to metastatic renal cell carcinoma to the tongue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006. p. 76–8.
45.
Huang H, Chang K, Chen T, Wu K, Ueng S. Renal cell carcinoma metastases in the head and neck. Chang Gung Med J. 2006. p. 59–65.
46.
Cochrane T, Cheng L, Crean S. Renal cell carcinoma: A rare metastasis to the tonguea case report. Dent Update. 2006. p. 186–7.
47.
Del Rosario Regalado R, Alvarez G, S, Martinez C, T, Lopez H, et al. Lingual metastasis from renal carcinoma. Rev Esp Cir Oral y Maxilofac. 2007. p. 179–81.
48.
Longo R, Baldini D, Gasparini G. An atypical tongue metastasis of renal cell carcinoma in a patient with metachronous hepatocellular carcinoma. Cancer Therapy. 2008. p. 707–10.
49.
Will T, Agarwal N, Petruzzelli G. Oral cavity metastasis of renal cell carcinoma: A case report. J Med Case Rep. 2008. p. 313.
50.
Basely M, Bonnel S, Maszelin P, Vardalle P, Bussy E, Jaureguiberry J. A rare presentation of metastatic renal clear cell carcinoma to the tongue seen on FDG PET. Clin Nucl Med. 2009. p. 566–9.
51.
Yoshitomi I, Kawasaki G, Mizuno A, Nishikido M, Hayashi T, Fujita S. Lingual metastasis as an initial presentation of renal cell carcinoma. Med Oncol. 2011. p. 1389–94.
52.
Ogunyemi O, Rojas A, Hematpour K, Rogers D, Head C, Bennet C. Metastasis of genitourinary tumors to the head neck region. Eur Arch Otolarhinolaryngol. 2010. p. 273–9.
53.
Morvan J, Veyrières J, Mimouni O, Cathelinaud O, Allali L, Verdalle P. Clear-cell renal carcinoma metastasis to the base of the tongue and sphenoid sinus: Two very rare atypical ENT locations. Eur Ann Otorhinolaryngol Head Neck Dis. 2011. p. 91–4.
54.
Wadasadawala T, Kumar P, Agarwal J. Ghosh-Laskar S. Palliation of dysphagia with radiotherapy for exophytic base tongue metastases in a case of renal cell carcinoma. Indian J Urol. 2011. p. 550–2.
55.
Ghazali N, Davis C, Barrett A, Tighe J. Bilateral asynchronous renal cell carcinoma with metastatic involvement of the tongue. Case Rep Pathol. 2012. p. 729642.
56.
Ganini C, Lasagna A, Ferraris E, Gatti P, Paglino C, Imarisio I, et al. Lingual metastasis from renal cell carcinoma: a case report and literature review. Rare Tumors. 2012. p. 41.
57.
Balliram S, Goetz L, Ramsoobhag K, Narinesingh D, Medford S, Naraynsingh V. Renal cell carcinoma presenting as a tongue lesion. J Oral Maxillofac Surg. 2012. p. 1605–8.
58.
Mazeron R, Fenoll L, Mathieu M, Dumas I, Haie-Meder C. Brachytherapy for isolated tongue metastasis of renal clear cell carcinoma. Eur Ann Otorhinolaryngol Head Neck Dis. 2013. p. 149–51.
59.
Ray A, Bhattacharya J, Ganguly S. Renal cell carcinoma presenting with oral tongue metastasis: a rare case presentation. J Cancer Res Ther. 2013. p. 117–8.
60.
Abbaszadeh-Bidokhty H, Motallebnejad M, Rajabi-Moghaddam M. Metastatic renal carcinoma presenting as clear-cell tumor in tongue: a case report. Iran J Otorhinolaryngol. p. 185–9.
61.
Lieder A, Guenzel T, Lebentrau S, Schneider C, Franzen A. Diagnostic relevance of metastatic renal cell carcinoma in the head and neck: An evaluation of 22 cases in 671 patients. Int Braz J Urol. 2017. p. 202–8.
62.
Miah M, White S, Oommen G, Birney E, Majumdar S. Late simultaneous metastasis of renal cell carcinoma to submandibular and thyroid glands seven years after radical nephrectomy. Int J Otolaryngol. 2010.
63.
Mj O, Zincke H, Utz D, Bernatz P. The treatment of renal cell carcinoma with solitary metastasis. J Urol. 1978. p. 540–2.
64.
Tanriverdi O. Review on targeted treatment of patients with advance stage renal cell-carcinoma: a medical oncologist’s perspective. Asian Pac J Cancer Prev. 2013. p. 609–17.
65.
Kassab A, Foster B, M. Recurrent facial metastasis from renal-cell carcinoma: review of the literature and case report. J Oral Maxillofac Surg. 1995. p. 74–7.
66.
Jonasch E, Gao J, Rathmell W. Renal cell carcinoma. BMJ. 2014. p. 4797.
The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.
,
