,
Department of Internal Diseases, Cantonal Hospital Zenica , Zenica , Bosnia and Herzegovina
Department of Medical Biochemistry, Faculty of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina
Clinic for Cardiovascular Surgery, University Clinical Center Tuzla , Tuzla , Bosnia and Herzegovina
Department of Internal Diseases, Cantonal Hospital Zenica , Zenica , Bosnia and Herzegovina
Department of Internal Diseases, Cantonal Hospital Zenica , Zenica , Bosnia and Herzegovina
Aim
To asses relation of serum high sensitive C-reactive protein (hsCRP) level with albumin concentration in daily urine in patients with diabetes mellitus type 2 (T2DM).
Methods
The prospective study included 69 patients with T2DM, both sexes (24 males, 45 females), aged 30-82 years. They were
divided into two groups: patients with T2DM and normoalbuminuria (T2DM-NA; n=40) and patients with T2DM and microalbuminuria (T2DM-MA; n=29). Patients were hospitalized at the Department of Internal Medicine, Cantonal Hospital Zenica, in the period January-April 2014. Immunonephelometry measurement of hsCRP was performed on the Nephelometer Analyzer BN II (Siemens, Germany).
Results
Frequency of patients in T2DM-NA and T2DM-MA groups was not significantly different in relation to sex and age.
There was significant difference in relation to duration of diabetes ( p=0.001). Average glucose and HbA1c levels were significantly higher in T2DM-NA group comparing to T2DM-MA group (p=0.008 and p=0.047, respectively). Serum creatinine (p=0.011), urea (p=0.009) and hsCRP (p=0.005) were significantly higher in T2DM-MA group compared to T2DM-NA group. Urinary albumin showed significantly positive correlation with the hsCRP (rho=0.286; p=0.017), urea (rho=0.503) and creatinine (rho=0.438) (p<0.0005). A one unit (mg/L) increase in hsCRP concentration
was associated with 11.5% increase of odds of microalbuminuria OR=1.115; 95% CI 1.014-1.225; p=0.025).
Conclusion
Significantly higher values of serum hsCRP in patients with type 2 diabetes mellitus and microalbuminuria in comparison
to those with normoalbuminuria as well as the correlation of values of inflammatory marker with urinary albumin implicate a low grade inflammation in the progression of diabetic nephropathy.
This work is licensed under a Attribution-NonCommercial-NoDerivatives 4.0 International 
3
Dicky Febrianto, Soebagijo Adi Soelistijo, Artaria Tjempakasari
(2023)
Correlation between Serum High-Sensitivity C-Reactive Protein Level and Severity of Albuminuria Measured by Urine Albumin-to-Creatinine Ratio in Type 2 Diabetic Patients
Current Internal Medicine Research and Practice Surabaya Journal, 4(2)
10.20473/cimrj.v4i2.49152
Emir Bećirović, Minela Bećirović, Sabina Šegalo, Amir Bećirović, Semir Hadžić, Kenana Ljuca, Emsel Papić, Lamija Ferhatbegović, Malik Ejubović, Amira Jagodić Ejubović, Amila Kovčić, Armin Šljivo, Emir Begagić
(2025)
Hemogram-derived ratios as prognostic markers for major adverse cardiovascular events in patients with non-ST-segment elevation myocardial infarction
World Journal of Methodology, 15(2)
10.5662/wjm.v15.i2.98143
Ahmad El Askary, Amal F. Gharib, Mazen Almehmadi, Maha Mahfouz Bakhuraysah, Abdulaziz Ali Al Hajjiahmed, Layla Ibrahim Al-Hejji, Mohammed S. Alharthi, Alaa Shafie
(2021)
The role of vitamin D deficiency and elevated inflammatory biomarkers as risk factors for the progression of diabetic nephropathy in patients with type 2 diabetes mellitus
Open Chemistry, 19(1)
10.1515/chem-2021-0107The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.