Lenticulostriate vasculopathy (LSV) is a relatively common fi nding in routine cranial ultrasound examination that has been associated with many infectious and non-infectious conditions. The aim of this review was to provide a better understanding of LSV ultrasound fi nding, as well as the need for further laboratory and imaging examinations in infants. The most of the published studies represented small series, with few prospective long-term studies involving the control groups. Authors have mostly found an association between LSV, especially higher-grade (although there is no universally accepted classifi cation) with congenital cytomegalovirus (CMV) infection, classifying those children as at risk for sensorineural hearing loss. In contrast, some authors pointed out that LSV could be found relatively often, and believe that isolated LSV, especially lower-grade, is not predictive for an unfavourable outcome and a long-term prognosis. Therefore, although 35 years have passed since the fi rst publication of LSV, there is still no consensus among experts on the clinical signifi cance of isolated LSV, but caution is certainly needed given the fact that most infants with congenital CMV are asymptomatic.
Grant E, Williams A, Schellinger D, Slovis T. Intracranial calcification in the infant and neonate: evaluation by sonography and CT. Radiology. 1985. p. 63–8.
2.
Dejong E, Lopriore E, Vossen A, Steggerda S, Pas T, Kroes A, et al. Is routine TORCH screening warranted in neonates with lenticulostriate vasculopathy. Neonatology. 2010. p. 274-e278.
3.
Sisman J, Rosenfeld C. Lenticulostriate vasculopathy in neonates: Is it a marker of cerebral insult? Critical review of the literature. Early Hum Dev. 2015. p. 423–6.
4.
Leijser L, Steggerda S, De Bruine F, Van Zuijlen A, Van Steenis A, Walther F, et al. Lenticulostriate vasculopathy in very preterm infants. Arch Dis Child Fetal Neonatal Ed. 2010. p. 42–6.
5.
Shin H, Kim M, Lee H, Namgung R, Park K, Lee M. Imaging patterns of sonographic lenticulostriate vasculopathy and correlation with clinical and neurodevelopmental outcome. J Clin Ultrasound. 2015. p. 367–74.
6.
Cantey J, Sisman J. The etiology of lenticulostriate vasculopathy and the role of congenital infections. Early Hum Dev. 2015. p. 427–30.
7.
Hughes P, Weinberger E, Shaw D. Linear areas of echogenicity in the thalami and basal ganglia of neonates: an expanded association. Radiol. 1991. p. 103–5.
8.
Chamnanvanakij S, Rogers C, Luppino C, Broyles S, Hickman J, Perlman J. Linear hyperechogenicity within the basal ganglia and thalamus of preterm infants. Pediatr Neurol. 2000. p. 129–33.
9.
Kriss V, Kriss T. Doppler sonographic confirmation of thalamic and basal ganglia vasculopathy in three infants with trisomy 13. J U M. 1996. p. 523–6.
10.
Teele R, Hernanz-Schulman M, Sotrel A. Echogenic vasculature in the basal ganglia of neonates: a sonographic sign of vasculopathy. Radiol. 1988. p. 423–7.
11.
Kandasamy Y, Alcock G, Koh THHG. Lenticulostriate vasculopathy in twin-to-twin transfusion syndrome. J Perinatol. 2006. p. 780–2.
12.
Ivanov I, Zlatareva D, Pacheva I, Panova M. Does lenticulostriate vasculopathy predipose to ischemic brain infarct? A case report. JCU. 2012. p. 607–10.
13.
Shefer-Kaufman N, Mimouni F, Stavorovsky Z, Meyer J, Dollberget S. Incidence and clinical significance of echogenic vasculature in the basal ganglia of newborns. Am J Perinatol. 1999. p. 315–9.
14.
Cabanas F, Pellicer A, Valverde E, Morales C, Queroet J. Central nervous system vasculopathy in neonatal lupus erythematosus. Pediatr Neurol. 1996. p. 124–6.
15.
Coley B, Rusin J, Boue D. Importance of hypoxic/ischemic conditions in the development of cerebral lenticulostriate vasculopathy. Pediatr Radiol. 2000. p. 846–55.
16.
Dahle A, Fowler K, Wright J, Boppana S, Britt W, Pass R. Longitudinal investigation of hearing disorders in children with congenital cytomegalovirus. J Am Acad Audiol. 2000. p. 283–90.
17.
Duranović V, Krakar G, Mejaski-Bosnjak V, Lujić L, Gojmerac T, Marn B. Lenticulostriatal vasculopathy -a marker for congenital cytomegalovirus infection? Coll Antropol. 2011. p. 149–53.
18.
Giannattasio A, Costanzo D, Milite P, P, Martino D, Capone D, et al. Is lenticulostriated vasculopathy an unfavorable prognostic finding in infants with congenital cytomegalovirus infection? J Clin Virol. 2017. p. 31–5.
19.
Sisman J, Chalak L, Heyne R, Pritchard M, Weakley D, Brown L, et al. Lenticulostriate vasculopathy in preterm infants: a new classification, clinical associations and neurodevelopmental outcome. J Perinatol. 2018. p. 1370–8.
20.
Park K, Kim H, Ko S, Shin S, Lee Y, Han B. Clinical significance of neonatal lenticulostriate vasculopathy: association with congenital cytomegalovirus infection. Neonatal Med. 2017. p. 171–7.
21.
Pass R. Congenital cytomegalovirus infection: screening and treatment. J Pediatr. 2010. p. 179–80.
22.
Makhoul I, Eisenstein I, Sujov P, Soudack M, Smolkint, Tamir A, et al. Neonatal lenticulostriate vasculopathy: further characterisation. Arch Dis Child Fetal Neonatal Ed. 2003. p. 410–4.
23.
Wang H, Kuo M, Chang T. Sonographic lenticulostriate vasculopathy in infants: some associations and a hypothesis. AJNR Am J Neuroradiol. 1995. p. 97–102.
24.
Amir J, Schwarz M, Levy I, Haimi-Cohen Y, Pardo J. Is lenticulostriated vasculopathy a sign of central nervous system insult in infants with congenital CMV infection? Arch Dis Child. 2011. p. 846–50.
25.
Bilavsky E, Schwarz M, Pardo J. Lenticulostriated vasculopathy is a high-risk marker for hearing loss in congenital cytomegalovirus infections. Acta pediatrica. 2015. p. 388–94.
26.
Ronchi A, Zeray F, Lee L, Ronchi A, Zeray F, Lee L, et al. Evaluation of clinically asymptomatic high risk infants with congenital cytomegalovirus infection. J Perinatol. 2020. p. 89–96.
27.
Hong SY, Yang J, Li SY, Lee IC. Lenticulostriate vasculopathy in brain ultrasonography is associated with cytomegalovirus infection in newborns. Pediatr Neonatol. 2015. p. 408–14.
28.
Giannattasio A, Costanzo D, Milite P, De Marino P, Capone D, Romano E, et al. Is lenticulostriated vasculopathy an unfavorable prognostic finding in infants with congenital cytomegalovirus infection? J Clin Virol. 2017. p. 31–5.
29.
Barton M, Forrester A, Mcdonald J. Update on congenital cytomegalovirus infection: prenatal prevention, newborn diagnosis, and management .Paediatr Child Health. 2020. p. 395–6.
30.
Fabre C, Tosello B, Pipon E, Gire C, Chaumoitre K. Hyperechogenicity of lenticulostriate vessels: a poor prognosis or a normal variant? A seven year retrospective study. Pediatr Neonatol. 2018. p. 553–60.
31.
Maayan-Metzger A, Leibovitch L, Schushan-Eisen I, Soudack M, Strauss T. Risk factors and associated diseases among preterm infants with isolated lenticulostriate vasculopathy. J Perinatol. 2016. p. 775–8.
32.
Coley B, Rusin J, Boue D. Importance of hypoxic/ischemic conditions in the development of cerebral lenticulostriate vasculopathy. Pediatr Radiol. 2000. p. 846–55.
33.
Mittendorf R, Covert R, Pryde G, Lee K, Ben-Ami T, Yousefzadeh D. Association between lenticulostriate vasculopathy (LSV) and neonatal intraventricular hemorrhage (IVH). J Perinatol. 2004. p. 700–5.
34.
Chang C. Clinical significance of lenticulostriate vasculopathy. ARC J Pediatr. 2016. p. 4–8.
35.
El Ayoubi M, De Bethmann O, Firtion G. Monset-Couchard M. Neonatal lenticulostriate vasculopathy. Mid and longterm outcome (70 cases). Arch Pediatr. 2004. p. 18–23.
36.
Shin H, Kim M, Lee H. Imaging patterns of sonographic lenticulostriate vasculopathy and correlation with clinical and neurodevelopmental outcome. J Clin Ultrasound. 2015. p. 367–74.
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