Aim To analyse the association of human leukocyte antigen B27 with clinical and laboratory parameters in patients with juvenile idiopathic arthritis (JIA) at the disease onset. Methods A retrospective review of medical records of 25 HLAB27 positive and 25 HLA-B27 negative JIA patients was performed. The diagnosis of JIA was based on the 1997-2001 International League Against Rheumatism (ILAR) criteria. Collected data: age, sex, HLA- B27 antigen presence, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid-factor (RF), antinuclear antibody (ANA), fever, rash, uveitis, enthesitis, inflamed joints and subtype of JIA. Results HLA- B27 positive study group had more boys (p=0.01), higher erythrocyte sedimentation rate (p=0.038), higher presence of fever (p= 0.025) and enthesitis (p=0.024). Any significant difference in age of the disease onset, CRP, ANA, RF, rash, uveitis, inflamed joint and dactylitis was not noticed. The most common subtype of JIA in the HLA-B27 positive patients was ERA (60%). Conclusion This study showed that the presence of HLA- B27 antigen plays a significant role in determining the presenting clinical and laboratory characteristics in JIA patients.
Srivastava R, Phatak S, Yadav A, Bajpai P, Aggarwal A. HLA B27 typing in 511 children with juvenile idiopathic arthritis from India. Rheumatol Int 2016:1407–11.
2
Peltoniemi S, Nordal E, Lahdenne P, Aalto K. 8-year follow-up study: differences between HLA-B27 positive and negative children with juvenile idiopathic arthritis in Finland. Arthritis Rheumatol 2015:10.
3
Fisher C, Ciurtin C, Leandro M, Sen D, Wedderburn L. Similarities and Differences Between Juvenile and Adult Spondyloarthropathies. Front Med 2021:16.
4
Liu C, Raj S, Chen C, Hung K, Chou C, Chen I, et al. HLA-B27-mediated activation of TNAP phosphatase promotes pathogenic syndesmophyte formation in ankylosing spondylitis. J Clin Invest 2019:5357–73.
5
Aschermann S, Englbrecht M, Bergua A, Spriewald B, Said-Nahal R, Breban M, et al. Presence of HLA-B27 is associated with changes of serum levels of mediators of the Wnt and hedgehog pathway. Joint Bone Spine 2016:43–6.
6
Coates L, Baraliakos X, Blanco F, Blanco-Morales E, Braun J, Chandran V, et al. The phenotype of axial spondyloarthritis: is it dependent on HLA-B27 status? Arthritis Care Res 2021:856–60.
7
Tay S, Yeo J, Leong J, Albani S, Arkachaisri T. Juvenile Spondyloarthritis: What more do we know about HLA-B27, enthesitis, and new bone formation? Front Med 2021:666772.
8
Chhabra A, Robinson C, Houghton K, Cabral D, Morishita K, Tucker L, et al. Long-term outcomes and disease course of children with juvenile idiopathic arthritis in the ReACCh-Out cohort: a two-centre experience. Rheumatology 2020:3727–30.
9
Marino A, Weiss P, Brandon T, Lerman M. Juvenile Spondyloarthritis: focus on uveitis. Pediatr Rheumatol Online J 2020:70.
10
Guo R, Cao L, Kong X, Liu X, Xue H, Shen L, et al. Fever as an initial manifestation of enthesitis-related arthritis subtype of juvenile idiopathic arthritis: retrospective study. PLoS One 2015:1–6.
11
Berntson L, Nordal E, Aalto K. HLA-B27 predicts a more chronic disease course in an 8-year follow up cohort of patients with juvenile idiopathic arthritis. J Rheumatol 2013:725–31.
12
Cassidy J, Pett R. Textbook of Pediatric Rheumatology 2005:206–300.
13
Goirand M, Breton S, Chevallier F, Duong N, Uettwiller F, Melki I, et al. Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre. Pediatr Rheumatol Online J 2018:16–21.
14
Żuber Z, Turowska-Heydel D, Sobczyk M, Chudek J. Prevalence of HLA-B27 antigen in patients with juvenile idiopathic arthritis. Reumatologia 2015:125–30.
15
Stanevicha V, Eglite J, Zavadska D, Sochnevs A, Lazareva A, Guseinova D, et al. HLA B27 allele types in homogeneous groups of juvenile idiopathic arthritis patients in Latvia. Pediatr Rheumatol Online J 2010:26.
16
Chen B, Li J, He C, Li D, Tong W, Zou Y, et al. Role of HLA-B 27 in the pathogenesis of ankylosing spondylitis. Mol Med Rep 2017:1943–51.
17
Thomson W, Barrett J, Pepper D, Kennedy L, Ollier L, Silman W, et al. Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations In UK patients. Rheumatology 2002:1183–9.
18
Hinks A, Cobb J, Marion M, Prahalad S, Sudman M, Bowes J, et al. Dense genotyping of immune loci in juvenile idiopathic arthritis identifies 14 new susceptibility loci. Nat Genet 2013:664–9.
19
Horton D, Shenoi S. Review of environmental factors and juvenile idiopathic arthritis. Open Access Rheumatol 2019:253–67.
20
Twilt M, Pradsgaard D, Spannow A, Horlyck A, Heuck C, Herlin T. Joint cartilage thickness and automated determination of bone age and bone health in juvenile idiopathic arthritis. Pediatr Rheumatol Online J 2017:63.
21
Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet 2007:767–78.
22
Martini A, Ravelli A, Avcin T, Beresford M, Burgos-Vargas R, Cuttica R, et al. Pediatric Rheumatology International Trials Organization (PRIN-TO). Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus. J Rheumatol 2019:190–7.
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