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HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia

By
Tina Christina Lumban Tobing ,
Tina Christina Lumban Tobing
Contact Tina Christina Lumban Tobing

Department of Child Health, School of Medicine, Universitas Sumatera Utara, Medan, Indonesia

Teddy Ontoseno ,
Teddy Ontoseno

Department of Child Health, School of Medicine, Universitas Airlangga, Indonesia

Sri Endah Rahayuningsih ,
Sri Endah Rahayuningsih

Department of Child Health, School of Medicine, Universitas Padjajaran, Indonesia

Ratna Akbari Ganie ,
Ratna Akbari Ganie

Department of Clinical Pathology, Universitas Sumatera Utara, Indonesia

Yahwardiah Siregar
Yahwardiah Siregar

Department of Biochemistry, School of Medicine, Universitas Sumatera Utara, Indonesia

Abstract

Rheumatic heart disease (RHD) is influenced by genetic factor, microorganism's virulence, and environmental factor. The aim of this study was to determine human leukocyte (HLA)-DRB1 allele among children with RHD in Medan, Indonesia. Methods
An observational study was conducted at the Department of Child Health, Haji Adam Malik Hospital Medan from April to June 2017. Inclusion criteria were children aged 5-18 years diagnosed with RHD. Children with concomitant congenital heart disease were excluded. HLA-DRB1 alleles were analyzed using the PCR sequence-specific priming (SSP) technique. Statistical analysis was done using computer software.
Results
A total of 62 children were enrolled. The mean age of children was 12.6 (SD 3.44) years; 33 (53.2%) were male. The most dominant allele was HLA-DRB1*12, followed by HLA-DRB1*15.
Conclusion
It is proven in this research that RHD is influenced by genetic factor with HLA-DRB1*12 allele found to be the most common allele in children with RHD in Medan, Indonesia.

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