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Original article

The influence of anthropometric parameters on the concentration of globulin that binds sex hormones during the menopausal transition

By
Dženana Softić Orcid logo ,
Dženana Softić
Contact Dženana Softić

Department of Gynaecology and Obstetrics, University Clinical Centre Tuzla, Bosnia and Herzegovina

Lejla Mešalić ,
Lejla Mešalić

School of Medicine, University of Tuzla; Tuzla, Bosnia and Herzegovina

Delila Softić
Delila Softić

Institute for Emergency Medical Assistance of Canton Sarajevo, Bosnia and Herzegovina

Abstract

Aim To determine the effect of body mass index (BMI) and waist-hip ratio (WHR) on the concentration of circulating sex hormone-binding globulin (SHBG) throughout the menopausal transition.
Methods This cross-sectional study included 150 women divided into three groups: premenopausal (n=50), perimenopausal (n=50), and postmenopausal (n=50). The processing of the test women consisted of three phases: inter-view, blood sampling and determination of BMI and WHR. The SHBG concentration was determined from the blood, and BMI and WHR were measured.
Results The BMI and WHR of the post-menopausal women were significantly higher comparing to the other two groups, while the postmenopausal SHBG was significantly lower compared to the premenopausal con-centration. In all three groups, a significant negative correlation was found between SHBG and BMI (Rho= -0.385; p<0.05), and between SHBG and WHR (Rho= -0.411; p<0.05). By the univariate regression analysis model, it was determined that BMI (β= -0.594; p<0.001) and WHR (β= -0.407; p=0.003) were independently negative predictors of SHBG in postmenopausal women, while in the multivariate regression analysis model only BMI as an independently negative predictor of SHBG in postmenopausal women was found (β= -0.263; p=0.024).
Conclusion The value of SHBG during the menopausal transition decreases and women with higher BMI and WHR have lower values of SHBG regardless of the duration of menopause. 
Considering the connection between SHBG and anthropometric parameters, and the drop in its values upon entering and passing through the menopausal transition as such it can be used as a predictor for an increased risk of cardiovascular diseases and metabolic syndrome in a selected group of women.

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Funding Statement

No specific funding was received for this study.

Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

 

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