Aim To investigate the relationship between recovered hepatitis B infection with appearance of toxic propylthiouracil (PTU) hepatitis and point out the growing importance of the use of drugs in the development of hepatitis. Methods A case of a 45-year-old female patient with suspicion of acute viral hepatitis who had polypragmasy of drugs in the last ten years, due to the polymorphism of symptoms/illnesses (diabetes mellitus, depression, hypertension, hypothyroidism) was presented. Results A female patient had hyperthyroidism after resolved viral hepatitis B with HBsAg seroconversion (HBsAg negative, antiHBs positive). PTU had the greatest potential for hepatotoxicity of all administered drugs. After corticosteroid therapy there was a significant improvement in liver function tests. In the course of the disease there was no change of hepatitis markers and exacerbations of hepatitis B. Conclusion Clinical practice should comprehensively monitor the effects of the intricate and tight connection between drugs, liver and endocrine system in order to better resolve all manifestations, complications and worsening of one or another organic system.
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Povezanost prebolovanog hepatitisa B s nastankom toksičnog hepatitisa uzrokovanog propiltiouracilom Lejla Čalkić, Lejla Bajramović-Omeragić Služba za zarazne bolesti, Kantonalna bolnica Zenica SAŽETAK Cilj Istražiti odnos između toksičnog hepatitisa uzrokovanog propiltiouracilom (PTU) i prebolovanog hepatitisa B, te ukazati na sve veći značaj upotrebe lijekova u nastanku hepatitisa. Metode Prikazan je slučaj 45-godišnje bolesnice koja je, u zadnjih desetak godina.
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Najveći potencijal za hepatotoksičnost od svih ordiniranih lijekova imao je PTU. Nakon kortikosteroidne terapije došlo je do znatnog poboljšanja jetrenih testova. U toku bolesti nije došlo do promjene hepatitis-markera i egzacerbacije hepatitisa B. Zaključak Klinička praksa mora cjelovito pratiti učinke zamršene i uske povezanosti lijekova, jetre i endokrinog sistema, kako bi bolje riješila sve manifestacije, komplikacije i pogoršanje jednog ili drugog organskog sistema.
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