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Review paper

Association of colorectal carcinoma and metabolic syndrome

By
Josip Lesko Orcid logo ,
Josip Lesko
Contact Josip Lesko

Department of Ear, Nose and Throat Surgery, University Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina

Pejana Rastović ,
Pejana Rastović

Health Centre Mostar, Mostar, Bosnia and Herzegovina

Anđela Azinović ,
Anđela Azinović

Health Centre Mostar, Mostar, Bosnia and Herzegovina

Sanja Ðurasović ,
Sanja Ðurasović

Department of Internal Diseases, University Clinical Hospital, Mostar, Bosnia and Herzegovina

Ante Bogut ,
Ante Bogut

Department of Psychiatry, University Clinical Hospital, Mostar, Bosnia and Herzegovina

Jelena Zovko ,
Jelena Zovko

Department of Psychiatry, University Clinical Hospital, Mostar, Bosnia and Herzegovina

Marko Pavlović ,
Marko Pavlović

School of Medicine, University Mostar, Mostar, Bosnia and Herzegovina

Zdenka Zovko
Zdenka Zovko

Abstract

Aim
Colorectal carcinoma is one of the most common neoplasms, especially in Western countries and those with westernisation. On the other hand, high rate of metabolic syndrome (MetSy) has also been noticed, as well as in Western countries. It seems like these two conditions are somehow connected. In this study, we wish to explore some characteristics of colorectal carcinoma and its correlation with MetSy.
Methods
In this retrospective study the data were taken from medical records of 67 patients with colorectal carcinoma, and for 30 healthy controls. Input parameters of patients were compared mutually, as well as with parameters of healthy, control examinees that had negative screening colonoscopy for neoplasm.
Results
Average age of patients was 68 years. The most frequent localisation of neoplasm was on rectum (53.7%) and most frequent level was Dukes C (38.8%). The patients had MetSy more frequently when compared with controls (p=0.048), and also they had more MetSy components (p=0.006). The link between MetSy and localisation of neoplasm was not found, neither with its pathohystological characteristics.
Conclusion
Patients with MetSy should be warned about the increased risk of colorectal carcinoma, and, in this way, motivated for earlier and more frequent screening colonoscopies, as well as of a change of unhealthy lifestyle.

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Due to this fact, it would be good for individuals with MetSy to be sent to screening colonoscopies more frequently and most certainly before 50 years of age. It is also instructive to inform the patients with MetSy about an increased risk of developing colorectal carcinoma, and to try motiva-ting patients to start a healthier lifestyle, physical exercise and appropriate food intake. FUNDING No specific funding was received for this study.
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