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Review paper

Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina

By
Tamer Bego ,
Tamer Bego
Contact Tamer Bego

Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

Tanja Dujić ,
Tanja Dujić

Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

Barbara Mlinar ,
Barbara Mlinar

Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

Sabina Semiz ,
Sabina Semiz

Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

Faculty of Engineering and Natural Sciences, International University of Sarajevo, Sarajevo, Bosnia and Herzegovina

Maja Malenica ,
Maja Malenica

Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

Besim Prnjavorac ,
Besim Prnjavorac

General Hospital of Tešanj, Tešanj, Bosnia and Herzegovina

Department of Pathophysiology, Faculty of Pharmacy, University Sarajevo, Sarajevo, Bosnia and Herzegovina

Barbara Ostanek ,
Barbara Ostanek

Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

Janja Marc ,
Janja Marc

Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

Anida Čaušević-Ramoševac ,
Anida Čaušević-Ramoševac

Bosnalijek, Pharmaceutical and Chemical Industry, Joint Stock Company, Sarajevo, Bosnia and Herzegovina

Adlija Čaušević
Adlija Čaušević

Department of Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

Abstract

Aim
To investigate association of two LPIN1 gene variations with main traits of metabolic syndrome (MS) (waist circumference,
body mass index, blood pressure, triglycerides, HDL-cholesterol and fasting glucose levels) in population from Bosnia and Herzegovina.
Methods
This study included 43 patients with metabolic syndrome and 43 healthy controls from General Hospital in Tešanj, Bosnia and Herzegovina. Subjects were genotyped for two LPIN1 gene variations (rs11693809: C>T and rs2716610: C>T) by real
time PCR method.
Results
In control subjects LPIN1 polymorphism, rs2716610: C>T, was significantly associated with a lower body mass index
(BMI) (p=0.008) and waist circumference (p=0.008). The second analyzed rs11693809: C>T polymorphism was associated with lower blood HbA1c levels (p=0.048) in a group of MS patients.
Conclusion
Results of our study suggest that rs2716610: C>T polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: C>T might affect a glucose control in patients with MS.

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