,
Department of Biology, Faculty of Natural Sciences and Mathematics, University of Tuzla , Tuzla , Bosnia and Herzegovina
School of Medicine, University of Tuzla , Tuzla , Bosnia and Herzegovina
Department of Biology, Faculty of Natural Sciences and Mathematics, University of Tuzla , Tuzla , Bosnia and Herzegovina
Department of Biology, Faculty of Natural Sciences and Mathematics, University of Tuzla , Tuzla , Bosnia and Herzegovina
School of Medicine, University of Tuzla , Tuzla , Bosnia and Herzegovina
Aim
To investigate association of factor V Leiden, prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Bosnian women.
Methods
A total of 60 women with two or more consecutive miscarriages before 20 weeks of gestation with the same partners and without history of known causes or recurrent pregnancy loss were included. A control group included 80 healthy women who had one or more successful pregnancies without history of any complication which could be associated with miscarriages. Genotyping of factor V Leiden, prothrombin G20210A, MTHFR C677T and PAI-1 4G/5G polymorphisms were performed by polymerase chain reaction/restriction fragments length polymorphism method (PCR/RFLP).
Results
Both factor V Leiden and MTHFR C677T polymorphisms were significantly associated with recurrent pregnancy loss (RPL) in Bosnian women while prothrombin G20210A and PAI-1 4G/5G polymorphisms did not show strongly significant association.
Conclusion
The presence of thrombophilic polymorphisms may predispose women to recurrent pregnancy loss. Future investigation should be addressed in order to find when carriers of those mutations, polymorphisms should be treated with anticoagulant therapy.
This work is licensed under a Attribution-NonCommercial-NoDerivatives 4.0 International 
6
K. N. Grigoreva, E. G. Demianovskaya, V. O. Bitsadze, J. Kh. Khizroeva, N. R. Gashimova, E. V. Slukhanchuk, I. S. Kalashnikova
(2023)
To a question about the necessity and indications for genetic screening in obstetric and gynecological practice
Obstetrics, Gynecology and Reproduction, 16(6)
10.17749/2313-7347/ob.gyn.rep.2022.373
Huiqin Sun, Lu Zhou, Yihan Lu, Yingchuan Li, Yan Huo, Weifeng Huang
(2024)
A Nomogram Model Containing Genetic Polymorphisms to Predict Risk of Pulmonary Embolism in Pregnant Women
International Journal of Women's Health, Volume 16()
10.2147/IJWH.S470644
Ana-Maria Vlădăreanu, Minodora Onisâi, Iuliana Iordan, Eugen Radu, Adrian Roşca, Octavian Munteanu, Dan Sebastian Soare, Cristina Mambet, Suzana Elena Voiculescu, Horia Bumbea, Irina Voican, Anca Nicolescu, Alina Mititelu, Raluca Nistor, Diana Secară, Anda Băicuș, Monica Cîrstoiu
(2024)
Frequency of thrombophilia-associated mutations and polymorphisms in pregnant women with a history of thrombosis or pregnancy complications
Turkish Journal of Biochemistry, 49(1)
10.1515/tjb-2022-0273
I. Aslan, S. Ozyigit, L.T. Paul, O. Tosun, P. Tulay
(2020)
Thrombophilia associated gene polymorphisms: Does use of medication, including anti-coagulants, minerals or folic acid, prevent the miscarriages?
Journal of Reproductive Immunology, 141()
10.1016/j.jri.2020.103172
Atakan Turgutkaya, Ayşe Hilal Eroğlu Küçükdiler, Alper Seyhan, Ali Bolaman, Zehra Manav Yiğit, Gökay Bozkurt, İrfan Yavaşoğlu
(2025)
The relationship of pregnancy losses with frequently-used hematologic parameters
Ege Tıp Dergisi, 64(2)
10.19161/etd.1549581
Mahsa Yousefian, Seyed Abdolhamid Angaji, Elham Siasi, Seyed Ali Rahmani, Shamci Abbasalizadeh Khiaban
(2021)
Association of Polymorphisms of F2 (rs3136520) and PAI-1(rs6090) Genes with Recurrent Pregnancy Loss in Iranian Azeri Women
Avicenna Journal of Clinical Medicine, 28(2)
10.52547/ajcm.28.2.118The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.