Aim To compare the effect of neoadjuvant chemotherapy based on taxane and/or anthracycline to the extent of an objective response in female patients with unresectable breast cancer with evaluation of the toxic profile of applied chemotherapy. Methods One hundred patients with histologically verified breast cancer, treated with neoadjuvant chemotherapy were divided into two groups: a study group A (50 patients), who had received 4 to 6 cycles of taxane-based chemotherapy, and control group B (50 patients), who had received 4 to 6 cycles of anthracyclines-based chemotherapy. Pathohistological response was evaluated after tumour excision and axillary resection at the end of chemotherapy and it was defined as pathologic complete (pCR), partial (pPR), or no response (pNR). Toxic effects were evaluated and quantified by the Common Terminology Criteria for Adverse Events v4.0. Results After neoadjuvant chemotherapy, 8% of patients in the group A achieved pCR, 54% achieved pPR, while 38% of patients had no tumour response to applied chemotherapy. In the group B pCR was achieved in 6%, pPR in 42% of patients, while 51% of patients were pNR to the administered chemotherapy. Significant reduction of tumour mass was achieved in the group of patients treated with taxanes: 20.00 (7.75-30.25) vs. 13.50 (6.00-25.00) mm (p=0.024). Toxicity of chemotherapy in group A and group B was within the limits of grade 2. Conclusion The addition of taxane to anthracycline-based neoadjuvant chemotherapy in patients with breast cancer resulted in a significant reduction in tumour mass compared to the group of patients treated with anthracyclines, but without increasing the overall side effects.
Howlader N, Noone A, Krapcho M, Miller D, Bishop K, Kosary C, et al. SEER Cancer Statistics Review. :1975–2014.
2.
Bethesda M. 1AD;
3.
Breast Cancer Facts & Fi-gures. Atlanta. 2015;
4.
Department of Health and Human Services. Report. 2017;
5.
Sparano J. Taxanes for breast cancer: an evidencebased review of randomized phase II and phase III trials. Clin Breast Cancer. 2000;32–40.
6.
Nahleh Z, Sivasubramaniam D, Dhaliwal S, Sundarajan V, Komrokji R. Residual cancer burden in locally advanced breast cancer: a superior tool. Curr Oncol. 2008;271–8.
7.
Arcamone F, Cassinelli G, Fantini G, Grein A, Orezzi P, Pol C, et al. 14-hydroxydaunomycin, a new antitumor antibiotic from S. peucetius var. caesius. Biotechnolo Bioeng. 1969;1101–10.
8.
Doroshow J, Davies K. Redox cycling og anthracyclines by cardiac mitochondria II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical. J Biol Chem. 1986;3068.
9.
Pinero-Madrona ARJ, Past A. present and future of primary systemic treatment in breast cancer. World J Obstet Gynecol. 2013;21–33.
10.
Heys S, Hutcheon A, Sarkar T, Ogston K, Miller I, Payne S, et al. Aberdeen Breast Group. Neoadjuvant docetaxel in breast cancer: 3-year survival results from the Aberdeen trial. Clin Breast Cancer. 2002;(Suppl 2):69–74.
11.
Eisenhauer E, Therasseb P, Bogaertsc J, Schwartzd L, Sargente D, Fordf R, et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 2009;228–47.
12.
Cortazar P, Zhang L, Untch M, Mehta K, Costantino J, Wolmark N, et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet. 2014;164–72.
13.
Common Terminology Criteria for Adverse Events, Version 4.0, DCTD, NCI, NIH, DHHS 2010. Cancer Therapy Evaluation Program. 10AD;
14.
Raut N, Chordiya N. NEO adjuvant chemotherapy in breast cancer: What have we learned so far? Indi. J Med Pediatr Oncol. 2010;8–17.
15.
Aigner J, Schneeweiss A, Sohn C, Marme F. The role of neoadjuvant chemotherapy in the management of primary breast cancer. Minerva Ginecol. 2011;261–74.
16.
Houssami N, Macaskill P, Minckwitz V, Marinovich G, Mamounas M, E. Meta-analysis ofthe association of breast cancer subtype and pathological complete response to neoadjuvant chemotherapy. Eur J Cancer. 2012;3342–54.
17.
Minckwitz V, Untch G, Blohmer M, Costa J, Eidtmann S, Fasching H, et al. Definition and impact of patologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtype. J Clin Oncol. 2012;1796–804.
18.
Ogawa Y, Moriya T, Kato Y, Oguma M, Ikeda K, Takashima T, et al. Immunohistochemical assessment for estrogen receptor and progesterone receptor status in breast cancer: analysis for a cut-off point as the predictor for endocrine therapy. Breast Cancer. 2004;267–75.
19.
Cortazar P, Zhang L, Untch M, Mehta K, Costantino J, Wolmark N, et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet. 2014;164–72.
20.
Rastogi P, Anderson S, Bear H, Geyer C, Kahlenberg M, Robidoux A, et al. Preoperative chemotherapy: updates of National Surgical Adjuvant Breast and Bowel Project Protocols B-18 and B-27. J Clin Oncol. 2008;778–85.
21.
Cuppone F, Bria E, Carlini P, Milella M, Felici A, Sperduti I, et al. Taxanes as primary chemotherapy for early breast cancer. Cancer. 2008;238–46.
22.
Doroshow J, Davies K. Redox cycling og anthracyclines by cardiac mitochondria II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical. J Biol Chem. 1986;3068–74.
23.
Chanan-Khan A, Srinivasan S, Czuczman M. Prevention and management of cardiotoxicity from antineoplastic therapy. J Support Oncol. 2004;251–66.
24.
Mackey J, Martin M, Pienkowski T, Rolski J, Guastalla J, Sami A, et al. for the TRIO/ BCIRG 001 investigators. Adjuvant docetaxel, doxorubicin, and cyclophosphamide in node-positive breast cancer: 10-year follow-up of the phase 3 randomised BCIRG 001 trial. Lancet Oncol. 2013;72–80.
25.
Martín M, Seguí M, Antón A, Ruiz A, Ramos M, Adrover E, et al. GEICAM 9805 Investigators. Adjuvant docetaxel for high-risk. N Engl J Med. 2010;2200–10.
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