Home Current Archive Editorial Team
About us
Aims and scope About Author Guidelines
News Contact
×
Home Current Archive Editorial board

Aims and scope About Author Guidelines
News Contact
Review paper
Received: 20.03.2019. >> Accepted: 08.10.2019. >> Published: 22.09.2019. Biochemistry
<< Prev | Next >>
PDF
https://doi.org/10.17392/1023-20

Peritoneal and upper genital tract tuberculosis

By
Alexandra Wagner Orcid logo ,
Alexandra Wagner
Contact Alexandra Wagner

Gynecological Tumour Centre and European Competence Centre for Ovarian Cancer, Berlin, Germany

View authors publications

Search this author on:

PubMed | Google Scholar
Ruža Arsenić ,
Ruža Arsenić

Institute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany

View authors publications

Search this author on:

PubMed | Google Scholar
Matthias David ,
Matthias David

Gynecological Tumour Centre and European Competence Centre for Ovarian Cancer, Berlin, Germany

View authors publications

Search this author on:

PubMed | Google Scholar
Jalid Sehouli ,
Jalid Sehouli

Gynecological Tumour Centre and European Competence Centre for Ovarian Cancer, Berlin, Germany

View authors publications

Search this author on:

PubMed | Google Scholar
Domagoj Vidosavljević ,
Domagoj Vidosavljević
Contact Domagoj Vidosavljević

Department of Gynaecology and Obstetrics, County General and Croatian War Veterans Hospital, Vukovar, Croatia

View authors publications

Search this author on:

PubMed | Google Scholar
Irena Rohr
Irena Rohr

Gynecological Tumour Centre and European Competence Centre for Ovarian Cancer, Berlin, Germany

View authors publications

Search this author on:

PubMed | Google Scholar

Abstract

Aim
 To present diagnostic and therapeutic possibilities for genital and peritoneal tuberculosis, mimicking to other pathological conditions, mainly, ovarian cancer.
Methods
Transabdominal and transvaginal ultrasound, computerized tomography, Ca125 and HE 4, ROMA-index (Risk of Ovarian Maligancy Algorithm index) and diagnostic laparoscopy were performed in order to diagnose genital tuberculosis in a female patient.
Results:
 A 23-year-old woman from Morocco presented with intermitting abdominal pain, unintentional weight loss and primary infertility. There was no positive family history for breast or ovarian cancer and no history of previous tuberculosis (TB). Elevated CA-125 level, HE 4 normal, ROMA-Index of 13.2 % suggested high risk for epithelial ovarian cancer (EOC). Ultrasound revealed free fluid, dilated fallopian tubes and a cystic mass near the right ovary. Suspecting fallopian tube or ovarian cancer, we performed exploratory laparoscopy, revealing adhesions, multiple miliary nodes and dilated fallopian tubes. Histological investigation revealed granulomatous abscessing salpingitis with suspicion of genital TB, so antituberculous therapy was administered with success.
Conclusion
 Female genital tuberculosis is very rare but important in differential diagnosis and should be kept in mind regarding suspected fallopian tube or ovarian carcinoma to prevent women from extensive surgery. An algorithm for possible differentiation between peritoneal/female genital TB and EOC may be helpful in clinical setting.

Keywords:

ovaries,
peritoneum,
tuberculosis

References

1.
Global Tuberculosis Report. World Health Organization; 2018.
2.
Namani S, Qehaja-Buçaj E, Namani D. Screening for genital tuberculosis in a limited resource country: case report. BMC Infect Dis. 2017. p. 130–8.
3.
Sharma J, Sharma E, Sharma S, Dharmendra S. Female genital tuberculosis: revisited. Indian J Med Res. 2018. p. 71-S83.
4.
Grace G, Devaleenal D, Natrajan M. Genital tuberculosis in females. Indian J Med Res. 2017. p. 425–36.
5.
Djuwantono T, Permadi W, Septiani L, Faried A, Halim D, Parwati I. Female genital tuberculosis and infertility: serial cases report in Bandung, Indonesia and literature review. BMC Res Notes. 2017. p. 683.
6.
Aliyu M, Aliyu S, Salihu H. Female genital tuberculosis: a global review. Int J Fertil Womens Med. 2004. p. 123–36.
7.
Jahromi N, Parsanezhad B, Ghane-Shirazi M, R. Female genital tuberculosis and infertility. Int J Gynaecol Obstet. 2001. p. 269–72.
8.
Golden M, Vikram H. Extrapulmonary tuberculosis: an overview. Am Fam Physician. 2005. p. 1761–8.
9.
Patel S, Lahamge K, Desai A. Dave1 K. Ovarian carcinoma or abdominal tuberculosis? -A diagnostic dilemma: study of fifteen cases. J Obstet Gynaecol India. 2012. p. 176–8.
10.
Hasanzadeh M, Naderi R, Hoshvar A, Shabane S, Shahidsales S. Female genital tract tuberculosis presenting as ovarian cancer. J Res Med Sci. 2014. p. 184–9.
11.
Adali E, Dulger C, Kolusari A, Kurdoglu M, Yildizhan R. Pelvic peritoneal tuberculosis simulating peritoneal carcinomatosis: high clinical suspicion and minnimally invasive procedure. Arch Gynecol Obstet. 2009. p. 867–8.
12.
Moore R, Miller C, Disilvestro P, Landrum L, Gajewski W, Bal J, et al. Evaluation of the diagnostic accuracy of the Risk of Ovarian Malignancy Algorithm in women with a pelvic mass. Obstet Gynecol. 2011. p. 280–8.
13.
Institut R, Koch. 2009.
14.
Berek J, Berek, Novak’s Gynecology. Williams and Wilkins; 2014.
15.
Koc S, Beydilli G, Tulunay G, Ocalan R, Boran N, Ozgul N, et al. Peritoneal tuberculosis mimicking advanced ovarian cancer: a retrospective review of 22 cases. Gynecol Oncol. 2006. p. 565–9.
16.
Xi X, Shuang L, Ting D, Han H, Ying M, Quan C, et al. Diagnostic dilemma of abdominopelvic tuberculosis:a series of 20 cases. J Cancer Res Clin Oncol. 2010. p. 1839–44.
17.
Piura B, Rabinovich A, Leron E, Yanai-Inbar I, Mazor M. Peritoneal tuberculosis mimicking ovarian carcinoma with ascites and elevated serum CA-125: case report and review of literature. Eur J Gynaecol Oncol. 2002. p. 120–2.
18.
Moss E, Hollingworth J, Reynolds M. The role of CA125 in clinical practice. J Clin Pathol. 2005. p. 308–12.
19.
Gosein M, Narinesingh D, Narayansingh G, Bhim N, Pearse A. Peritoneal tuberculosis mimicking advanced ovarian carcinoma: an important differential diagnosis to consider. BMC Res Notes. 2013. p. 88–9.
20.
Simsek H, Savas M, Kadayifci A, Tatar G. Elevated serum CA 125 concentration in patients with tuberculous peritonitis: a case-control study. Am J Gastroenterol. 1997. p. 1174–6.
21.
Wu C, Changchien C, Tseng C, Chang H, Ou Y, Lin H. Disseminated peritoneal tuberculosis simulating advanced ovarian cancer: a retrospective study of 17 cases. Taiwan J Obstet Gynecol. 2011. p. 292–6.
22.
Escudero J, Auge J, Filella X, Torne A, Pahisa J, Molina R. Comparison of serum Human Epididymis Protein 4 with Cancer Antigen 125 as a tumor marker in patients with malignant and nonmalignant diseases. Clin Chem. 2011. p. 1534–1534.
23.
Liu W, Yang J, Chi P, Zheng X, Dai S, Chen H, et al. Evaluating the clinical significance of serum HE4 levels in lung cancer and pulmonary tuberculosis. Int J Tuberc Lung Dis. 2013. p. 1346–53.
24.
Zhang L, Chen Y, Liu W, Wang K. Evaluating the clinical significances of serum HE4 with CA125 in peritoneal tuberculosis and epithelial ovarian cancer. Biomarkers. 2016. p. 168–72.
25.
Sehouli J, Stupin J, Schlieper U, Kuemmel S, Henrich W, Denkert C, et al. Actinomycotic inflammatory disease and misdiagnosis of ovarian cancer. Anticancer Research. 2006. p. 1727–31.

Citation

Copyright

Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

 

Article metrics

Google scholar: See link

{{ submission.title }}
Issue image
Vol 17, Issue 1, 2020
Digital dermatoglyphics in the evaluation of the genetic basis of breast cancer in Bosnian-Herzegovinian population - quantitative analysis Comparison of intubation condition and the quality of muscle relaxation between rocuronium and vecuronium using „timing principle“ Bone marrow adiposity is inversely associated with bone mineral density in postmenopausal females Fetuin-A Thr256Ser gene polymorphism as a mortality predictor in patients with chronic kidney disease on maintenance haemodialysis in Medan, Indonesia The relation between BRAFV600E mutation and clinicopathological characteristics of papillary thyroid cancer See full issue

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.