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Review paper
Received: 24.05.2017. >> Accepted: 04.07.2017. >> Published: 01.08.2017. Biochemistry
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https://doi.org/10.17392/916-17

Serum homocysteine levels in patients with probable vascular dementia

By
Salem Alajbegović Orcid logo ,
Salem Alajbegović
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Department of Endocrinology and Diabetes, Cantonal Hospital, Zenica , Zenica , Bosnia and Herzegovina

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Orhan Lepara ,
Orhan Lepara
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Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

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Almira Hadžović-Džuvo ,
Almira Hadžović-Džuvo

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

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Alma Mutevelić-Turković ,
Alma Mutevelić-Turković

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

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Lejla Alajbegović ,
Lejla Alajbegović

Representative office of Berlin-Chemie AG in Sarajevo , Sarajevo , Bosnia and Herzegovina

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Asija Zaćiragić ,
Asija Zaćiragić

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

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Nesina Avdagić ,
Nesina Avdagić

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

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Amina Valjevac ,
Amina Valjevac

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

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Nermina Babić ,
Nermina Babić

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

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Amela Dervišević
Amela Dervišević

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

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Abstract

Aim
To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD.
Methods
Serum concentration of tHcy was determined by the Fluorescence Polarization Immunoassay on the AxSYM System. Cognitive impairment was tested by the Mini Mental Status Examination (MMSE) score. Body mass index (BMI) was calculated for each subject included in the study.
Results
 Age, systolic, diastolic blood pressure and BMI did not differ significantly between the two groups. Mean serum tHcy concentration in the control group of subjects was 13.35 µmol/L, while in patients with probable VD it was significantly higher, 19.45 µmol/L (p=0.002). A negative but insignificant association between serum tHcy concentration and cognitive impairment in patients with probable VD was found.
Conclusion
Increased tHcy concentration in patients with probable VD suggests the possible independent role of Hcy in the pathogenesis of VD.

Keywords:

neurotoxicity,
cognitive impairment,
Mini-Mental State Examination

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Nivo homocisteina u serumu pacijenata s mogućom vaskularnom demencijom Salem Alajbegović 1 , Orhan Lepara 2* , Almira Hadžović-Džuvo Almira 2. Alma Mutevelić-Turković.
26.
Predstavništvo u Sarajevu; Bosna i Herzegovina SAŽETAK Cilj Ispitati koncentraciju ukupnog homocisteina (tHcy) u serumu pacijenata s mogućom vaskularnom demencijom (VD) i kod ispitanika kontrolne grupe, te utvditi povezanost između nivoa tHcy i kognitivnog oštećenja kod pacijenata s mogućom VD-om.
27.
Indeks tjelesne mase (ITM) izračunat je za svakog ispitanika uključenog u studiju.
28.
Utvrđena je negativna, ali ne signifikantna povezanost između serumske koncentracije tHcy i kognitivnog oštećenja kod pacijenata s mogućim VD-om.
29.
Zaključak Povećan nivo tHcy kod pacijenata s mogućim VD-om sugeriše na moguću nezavisnu ulogu Hcy u patogenezi VD-a. Ključne riječi: neurotoksičnost, kognitivno oštećenje, minimentalni status.

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