Home Current Archive Editorial Team
About us
Aims and scope About Author Guidelines
News Contact
×
Home Current Archive Editorial board

Aims and scope About Author Guidelines
News Contact
Review paper
Received: 24.05.2017. >> Accepted: 04.07.2017. >> Published: 01.08.2017. Biochemistry
<< Prev | Next >>
PDF
https://doi.org/10.17392/916-17

Serum homocysteine levels in patients with probable vascular dementia

By
Salem Alajbegović Orcid logo ,
Salem Alajbegović
Contact Salem Alajbegović

Department of Endocrinology and Diabetes, Cantonal Hospital, Zenica , Zenica , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Orhan Lepara ,
Orhan Lepara
Contact Orhan Lepara

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Almira Hadžović-Džuvo ,
Almira Hadžović-Džuvo

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Alma Mutevelić-Turković ,
Alma Mutevelić-Turković

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Lejla Alajbegović ,
Lejla Alajbegović

Representative office of Berlin-Chemie AG in Sarajevo , Sarajevo , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Asija Zaćiragić ,
Asija Zaćiragić

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Nesina Avdagić ,
Nesina Avdagić

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Amina Valjevac ,
Amina Valjevac

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Nermina Babić ,
Nermina Babić

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar
Amela Dervišević
Amela Dervišević

Department of Human Physiology, School of Medicine, University of Sarajevo , Sarajevo , Bosnia and Herzegovina

View authors publications

Search this author on:

PubMed | Google Scholar

Abstract

Aim
To investigate total homocysteine (tHcy) serum concentration in patients with probable vascular dementia (VD) and in agematched controls, as well as to determine an association between tHcy serum concentration and cognitive impairment in patients with probable VD.
Methods
Serum concentration of tHcy was determined by the Fluorescence Polarization Immunoassay on the AxSYM System. Cognitive impairment was tested by the Mini Mental Status Examination (MMSE) score. Body mass index (BMI) was calculated for each subject included in the study.
Results
 Age, systolic, diastolic blood pressure and BMI did not differ significantly between the two groups. Mean serum tHcy concentration in the control group of subjects was 13.35 µmol/L, while in patients with probable VD it was significantly higher, 19.45 µmol/L (p=0.002). A negative but insignificant association between serum tHcy concentration and cognitive impairment in patients with probable VD was found.
Conclusion
Increased tHcy concentration in patients with probable VD suggests the possible independent role of Hcy in the pathogenesis of VD.

Keywords:

neurotoxicity,
cognitive impairment,
Mini-Mental State Examination

References

1.
Lepara O, Alajbegovic A, Zaciragic A, Nakas-Icindic E, Valjevac A, Lepara D, et al. Elevated serum homocysteine level is not associated with serum C-reactive protein in patients with probable Alzheimer’s disease. J Neural Transm. 2009;1651–6.
2.
Zaključak Povećan nivo tHcy kod pacijenata s mogućim VD-om sugeriše na moguću nezavisnu ulogu Hcy u patogenezi VD-a. Ključne riječi: neurotoksičnost, kognitivno oštećenje, minimentalni status.
3.
Utvrđena je negativna, ali ne signifikantna povezanost između serumske koncentracije tHcy i kognitivnog oštećenja kod pacijenata s mogućim VD-om.
4.
Indeks tjelesne mase (ITM) izračunat je za svakog ispitanika uključenog u studiju.
5.
Predstavništvo u Sarajevu; Bosna i Herzegovina SAŽETAK Cilj Ispitati koncentraciju ukupnog homocisteina (tHcy) u serumu pacijenata s mogućom vaskularnom demencijom (VD) i kod ispitanika kontrolne grupe, te utvditi povezanost između nivoa tHcy i kognitivnog oštećenja kod pacijenata s mogućom VD-om.
6.
Nivo homocisteina u serumu pacijenata s mogućom vaskularnom demencijom Salem Alajbegović 1 , Orhan Lepara 2* , Almira Hadžović-Džuvo Almira 2. Alma Mutevelić-Turković.
7.
Nilson K, Gustafson L, Huktberg B. Relation between plasma homocysteine and Alzheimer’s Disease. Dement Geriatr Cogn Disord. 2002;7–12.
8.
Wang Y, He Y, Jiang W, Du B, Jin. Correlation between plasma level of homocysteine and cerebral large-artery atherosclerosis. Zhonghua Nei Ke Za Zhi. 2006;744–7.
9.
Kloppenborg R, Nederkoorn P, Van Der Graaf Y, Geerlings M. Homocysteine and cerebral small vessel disease in patients with symptomatic atherosclerotic disease. The SMART-MR study. Atherosclerosis. 2011;461–6.
10.
Lehotský J, Tothová B, Kovalská M, Dobrota D, Beňová A, Kalenská D, et al. Role of Homocysteine in the Ischemic Stroke and Development of Ischemic Tolerance. Front Neurosci. 2016;538.
11.
Haan M, Miller J, Aiello A, Whitmer R, Jagust W, Mungas D, et al. Homocysteine, B vitamins, and the incidence of dementia and cognitive impairment: results from the Sacramento Area Latino Study on Aging. Am J Clin Nutr. 2007;511–7.
12.
Luchsinger J, Tang M, Shea S, Miller J, Green R, Mayeux R. Plasma homocysteine levels and risk of Alzheimer disease. Neurology. 2004;1972–6.
13.
Moretti R, Caruso P, Ben D, Conti M, Gazzin C, Tiribelli S, et al. Vitamin D, homocysteine, and folate in subcortical vascular dementia and Alzheimer dementia. Front Aging Neurosci. 2017;169.
14.
Seshadri S. Homocysteine and the risk of dementia. Clin Chem. 2012;1059–60.
15.
Folin M, Baiguera S, Gallucci M, Conconi M, Liddo D, Zanardo R, et al. A cross-sectional study of homocysteine-, NO-levels, and CT-findings in Alzheimer dementia, vascular dementia and controls. Biogerontology. 2005;255–60.
16.
Kalaria R. Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease. Acta Neuropathol. 2016;659–85.
17.
Khedr E, Hamed S, El-Shereef H, Shawky O, Mohamed K, Awad E, et al. Cognitive impairment after cerebrovascular stroke: Relationship to vascular risk factors. Neuropsychiatr Dis Treat. 2009;103–16.
18.
Pernet P, Lasnier E, Vaubourdolle M. Evaluation of the AxSYM homocysteine assay and comparison with the IMx homocysteine assay. Clin Chem. 2000;1440–1.
19.
Loncarević N, Sulić M, Alajbegović E, Kucukalić A, A. The neurologist role in diagnostics and therapy of the Alzheimer’s disease. Med Arh. 2005;6–9.
20.
Folstein M, Folstein S, Mchugh P. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;189–98.
21.
Román G, Tatemichi K, Erkinjuntti T, Cummings J, Masdeu J, Garcia J, et al. Vascular dementia: diagnostic criteria for research studies: Report of the NINDS-AIREN International Workshop. Neurology. 1993;250–60.
22.
Cai C, Van Halm-Lutterodt X, Zhen N, Huang J, Xu X, Chen Y, et al. Association of MTHFR, SLC19A1 genetic polymorphism, serum folate, vitamin B12 and Hcy status with cognitive functions in Chinese adults. Nutrients. 2016;10.
23.
Wang B, Zhong Y, Yan H, Cui L. Meta-analysis of plasma homocysteine content and cognitive function in elderly patients with Alzheimer’s disease and vascular dementia. Int J Clin Exp Med. 2014;5118–23.
24.
Dolan H, Crain B, Troncoso J, Resnick S, Zonderman A, Obrien R. Atherosclerosis, dementia, and Alzheimer disease in the Baltimore longitudinal study of aging cohort. Ann Neurol. 2010;231–40.
25.
Tehlivets O. Homocysteine as a risk ractor for atherosclerosis: Is its conversion to S-Adenosyl-Lhomocysteine the key to deregulated lipid metabolism. J Lipids. 2011;702853.
26.
Spence J, Howard V, Chambless L, Malinow M, Pettigrew L, Stampler M, et al. Vitamin Intervention for Stroke Prevention (VISP) trial: Rationale and design. Neuroepidemiology. 2001;16–25.
27.
Ashjazadeh N, Fathi M, Shariat A. Evaluation of homocysteine level as a risk factor among patients with ischemic stroke and its subtypes. Iran J Med Sci. 2013;233–9.
28.
Schalinske K, Smazal A. Homocysteine imbalance: a pathological metabolic marker. Adv Nutr. 2012;755–62.
29.
Ganguly P, Alam S. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015;6.

Citation

Copyright

Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

 

Article metrics

Google scholar: See link

{{ submission.title }}
Issue image
Vol 14, Issue 2, 2017
Cytotoxic and genotoxic studies of essential oil from Rosa damascene Mill., Kashan, Iran Significance of parathyroid scintigraphy and correlation of findings with parathyroid hormone values in patients undergoing hemodialysis The effect of functional insulin therapy on glycaemic parameters in children with diabetes mellitus type 1 Importance of inflammatory markers and IL-6 for diagnosis and follow up of patients with type 2 diabetes mellitus Metformin use associated with lower risk of cancer in patients with diabetes mellitus type 2 See full issue

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.