,
Department for Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo , Sarajevo , Bosnia and Herzegovina
University Clinic of Pulmonary and Allergic Diseases , Golnik , Slovenia
Department for Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo , Sarajevo , Bosnia and Herzegovina
Department for Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo , Sarajevo , Bosnia and Herzegovina
Department for Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo , Sarajevo , Bosnia and Herzegovina
Faculty of Engineering and Natural Sciences, Faculty of Engineering and Natural Sciences, International University of Sarajevo , Sarajevo , Bosnia and Herzegovina
Department for Clinical Pharmacy, Faculty of Pharmacy, University of Sarajevo , Sarajevo , Bosnia and Herzegovina
General Hospital, Tešanj , Tešanj , Bosnia and Herzegovina
Department for Pathophysiology, Faculty of Pharmacy, University of Sarajevo , Sarajevo , Bosnia and Herzegovina
Department for Biochemistry and Clinical Analysis, Faculty of Pharmacy, University of Sarajevo , Sarajevo , Bosnia and Herzegovina
Aim
To analyse the long-term impact of altered metabolism on the level of mediators of inflammatory response in female patients with type 2 diabetes.
Methods
This study included 97 female patients with type 2 diabetes and 107 female, nondiabetic control subjects, who were recruited at the Clinical Centre University of Sarajevo and the General Hospital Tešanj. The effects of glycaemic control on markers of inflammatory response represented by C-reactive protein (CRP), fibrinogen, leukocytes, sedimentation rate, and cytokine IL-6 were tested. All subjects were free of evidence of infections, surgery, thyroid disease, polycystic ovarian syndrome, active liver and kidney damage. All biochemical analyses were performed according to standard International Federation of Clinical Chemistry (IFCC) protocols.
Results
A significant increase of fibrinogen (p<0.001), CRP (p=0.001), interleukin-6 (p=0.013), leukocytes (p<0.001) and sedimentation rate (p=0.008) in diabetic female population compared to control subjects was found. A significant correlation between CRP and haemoglobin A 1c (p=0.035), interleukin-6 and glucose (p=0.032), IL-6 and body mass index (p=0.007) was found.
Conclusion
Our data suggest that inflammation plays an important role in the pathogenesis of diabetes in female diabetic population. A more detailed study on a far larger number of subjects is needed if they were to be used effectively as biomarkers in the primary prevention of type 2 diabetes in this population.
This work is licensed under a Attribution-NonCommercial-NoDerivatives 4.0 International 
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