Home Current Archive Editorial Team
About us
Aims and scope About Author Guidelines
News Contact
×
Home Current Archive Editorial board

Aims and scope About Author Guidelines
News Contact
Review paper
Received: 11.05.2015. >> Accepted: 01.07.2015. >> Published: 18.04.2015. Biochemistry
<< Prev | Next >>
PDF
https://doi.org/10.17392/820-15

Impact of reperfusion therapy and infarct localization on frequency of premature ventricular beats in acute myocardial infarction

By
Davor Horvat ,
Davor Horvat
Contact Davor Horvat

Internal Disease Service, General Hospital Karlovac, Karlovac, Croatia

View authors publications

Search this author on:

PubMed | Google Scholar
Josip Vincelj
Josip Vincelj

Institute of Cardiovascular Diseases, Dubrava University Hospital, Zagreb, Croatia

University of Applied Health Studies, Zagreb, Croatia

School of Medicine Osijek, University J.J. Strossmayer Osijek, Osijek, Croatia

View authors publications

Search this author on:

PubMed | Google Scholar

Abstract

Aim
 To determine the impact of infarct localization and types of reperfusion therapy on the frequency of ventricular premature beats (VPBs) in patients with acute myocardial infarction (AMI) and reduced left ventricular ejection fraction (LVEF).
Methods
A total of 705 patients with acute ST elevation myocardial infarction (STEMI) were divided according to the infarct localization (anteroseptal, anterolateral, inferior and posterior) and reperfusion therapy (fibrinolysis or percutaneous coronary intervention with stenting) into two groups: LVEF<45% was an experimental group and LVEF>45% was a control group. The occurrence of VPBs<10 per hour was defined as a non-significant, and the occurrence of VPBs>10 per hour defined as a significant.
Results
 In patients with fibrinolysis therapy and LVEF<45% significant number of VPBs were in anteroseptal (p=0.017), anterolateral (p<0.001) and posterior AMI (p<0.001), but in patients with percutaneous coronary intervention (PCI) and LVEF<45% significant number of VPBs were only in anteroseptal AMI (p=0.001) localization.
Conclusion
 In patients with reduced ejection fraction in AMI, treatment with PCI method has a better antiarrhythmic effect compared to fibrinolysis treatment. 

Keywords:

fibrinolysis,
percutaneous coronary intervention,
ventricular arrhythmias

References

1.
Olgin J, Zipes D. Specific Arrhythmias: Diagnosis and Treatment. Elsevier/Saunders; 2005. p. 838–45.
2.
Drőgeműller A, Seidl K, Schiele R, Schneider S, Gitt A, Gotwik M. Prognostic value of non-sustained ventricular tachycardias after acute myocardial infarction in the thrombolytic era: importance of combination with frequent ventricular premature beats. Z Kardiol. 2003. p. 164–72.
3.
Timmer J, Breet N, Svilaas T, Haaksma J, Van Gelder I, Zijlstra F. Predictors of ventricular tachyarrhythmia in high-risk myocardial infarction patients treated with primary coronary intervention. Neth Heart J. 2010. p. 122–8.
4.
Volpi A, Cavalli A, Turato R, Barlera S, Santoro E, Negri E. Incidence and short-term prognosis of late sustained ventricular tachycardia after myocardial infarction: results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GI-SSI-3) Data Base. Am Heart J. 2001. p. 87–92.
5.
Newbi K, Thompson T, Stebbins A, Topol E, Califf R, Natale A. Sustained ventricular arrhythmias in patients receiving thrombolytic therapy: incidence and outcomes. Circulation. 1998. p. 2567–73.
6.
Breithardt G, Borggrefe M, Martinez-Rubio A, Budde T. Pathophysiological mechanisms of ventricular tachyarrhythmias. Eur Heart J. 1989. p. 9–18.
7.
Manolis A. Ventricular premature beats. 16AD.
8.
Ventricular premature beats. The Merck Manuals: The Merck Manual for Health Care Professionals. 16AD.
9.
Cha Y, Lee G, Klarich K, Grogan M. Premature ventricular contraction-induced cardiomyopathy. Circulation: Arrhythmia and Electrophysiology. 2012. p. 229–36.
10.
Eckardt L, Breithardt G. Drug-induced ventricular tachycardia. From Cell to Bedside. 6 th ed. Elsevier Saunders. p. 1001–8.
11.
John R, Tedrow U, Koplan B, Albert C, Epstein L, Sweeney M, et al. Ventricular arrhythmias and sudden cardiac death. Lancet. 2012. p. 1520–9.
12.
Solomon S, Zelenkofske S, Mcmurray J, Finn P, Velazqueze E, Ertl G. Sudden death in patients with myocardial infarction and left ventricular dysfunction, heart failure, or both. N Engl J Med. 2005. p. 2581–8.
13.
Terkelsen C, Christiansen E, Sorensen J, Kristensen S, Lassen J, Thuessen L. Primary PCI as the preferred reperfusion therapy in STEMI: it is a matter of time. Heart. 2009. p. 362–9.
14.
Bluazite I, Brazdzionyte J, Bluzhas J, Mickeviciene A. Signal-averaged electrocardiogram peculiarities of the first and recurrent myocardial infarction. JHong Kong Coll Cardiol. 1997. p. 119–25.
15.
Stone P, Raabe D, Jaffe A, Gustafson N, Müller J, Turi Z. Prognostic significance of location and type of myocardial infarction: independent adverse outcome associated with anterior location. J Am Coll Cardiol. 1998. p. 453–63.
16.
Gibson C, Ryan K, Kelley M, Rizzo M, Mesley R, Murphy S. Methodologic drift in the assessment of TIMI grade 3 flow and its implications with respect to the reporting of angiographic trial results. Am Heart J. 1999. p. 1179–84.
17.
Weaver W, Simes R, Betriu A, Grines C, Zijlstra F, Garcia E, et al. Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review. JAMA. 1997. p. 2093–8.
18.
Keeley E, Boura J, Grines C. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of 23 randomised trials. Lancet. 2003. p. 13–20.
19.
Breithard L, Schwarzmaier J, Borggrefe M, Haerten K, Seipel L. Prognostic significance of late ventricular potentials after acute myocardial infarction. Eur Heart J. 1983. p. 487–95.
20.
Pascale P, Schlaepfer J, Oddo M, Schaller M, Vogt P, Fromer P, et al. Ventricular arrhythmia in coronary artery disease: limits of a risk stratification strategy based on the ejection fraction alone and impact of infarct localization. Europace. 2009. p. 1639–46.
21.
Christoffels V, Moorman A. Why Are Some Regions of the Heart More Arrhythmogenic Than Others? Circulation: Arrhythmia and Electrophysiology. 2009. p. 195–207.
22.
Dave J, Lakhia R, Jha S. Ventricular Premature Complexes. 15AD.
23.
Bainey K, Fu Y, Wagner G, Goodman S, Ross A, Granger C, et al. Spontaneous reperfusion in ST-elevation myocardial infarction: comparison of angiographic and electrocardiographic assessments. Am Heart J. 2008. p. 248–55.
24.
Bainey K, Fu Y, Granger C, Hamm C, Holmes D, Neil O, et al. Benefit of angiographic spontaneous reperfusion in STEMI: does it extend to diabetic patients? Heart. 2009. p. 1331–6.
25.
Fujita M, Nakae I, Kihara Y, Hasegawa K, Nohara R, Ueda K. Determinants of collateral development in patients with acute myocardial infarction. Clin Cardiol. 1999. p. 595–9.
26.
Schuster E, Bulkley B. Ischemia at a distance after acute myocardial infarction: a cause of early postinfarction angina. Circulation. 1980. p. 509–15.
27.
Hofsten D, Wachtell K, Lund B, Molgaard H. Egstrup K. Prevalence and prognostic implications of non-sustained ventricular tachycardia in ST-segment elevation myocardial infarction after revascularization with either fibrinolysis or primary angioplasty. Eur Heart J. 2007. p. 407–14.
28.
Josip Vincelj. p. 4.
29.
Služba za internu medicinu, Opća bolnica Karlovac, Karlovac, 2 Zavod za bolesti srca i krvnih žila, Klinička bolnica Dubrava.
30.
Zdravstveno Veleučilište, Zagreb, Medicinski, Osijek, Sveučilište J, Strossmayera. Osijek; Hrvatska SAŽETAK Cilj Odrediti utjecaj lokalizacije infarkta i reperfuzijske terapije na učestalost ventrikulskih ekstrasistola (VES) kod pacijenata s akutnim infarktom miokarda (AIM) i reduciranom ejekcijskom frakcijom lijevog ventrikla (EFLV).
31.
Metode Ukupno je 705 bolesnika s akutnim infarktom miokarda i ST elevacijom (STEMI) podijeljeno prema lokalizaciji infarkta (anteroseptalni, anterolateralni, inferiorni i posteriorni) i reperfuzijskoj terapiji (fibrinoliza ili perkutana koronarna intervencija sa stentom) u dvije grupe: EFLV<45% kao ispitivana grupa, te EFLV>45% kao kontrolna grupa.
32.
Rezultati U pacijenata s fibrinolizom i EFLV<45% značajan broj VES-a bio je u anteroseptalnom (p=0,017), anterolateralnom (p<0,001) i posteriornom AIM-u (p<0,001), a u pacijenata s perkutanom koronarnom intervencijom (PCI) i EFLV<45% značajan broj VES-a bio je samo u anteroseptalnoj AIM.
33.
Zaključak U pacijenata sa smanjenom ejekcijskom frakcijom u AIM-u, tretman s PCI metodom imao je bolji antiaritmički efekat u odnosu na fibrinolitički tretman. Ključne riječi: fibrinoliza, perkutana koronarna intervencija.

Citation

Copyright

Authors retain copyright. This work is licensed under a Creative Commons Attribution 4.0 International License. Creative Commons License

 

Article metrics

Google scholar: See link

{{ submission.title }}
Issue image
Vol 13, Issue 2, 2015
Role of echocardiography in diagnosis and management of complete papillary muscle rupture caused by myocardial infarction Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina Genetic polymorphisms variants in interleukin-6 and interleukin- 1beta patients with obstructive sleep apnea syndrome in East Northern Turkey Effects of perioperative statin treatment on postoperative atrial fibrillation and cardiac mortality in patients undergoing coronary artery bypass grafting: a propensity score analysis Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus See full issue

The statements, opinions and data contained in the journal are solely those of the individual authors and contributors and not of the publisher and the editor(s). We stay neutral with regard to jurisdictional claims in published maps and institutional affiliations.